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About 3M Lab
About 3M Lab
Historically, the intestine was underestimated in medicine, seen primarily as a passive organ for digestion and nutrient absorption. However, research over the last two decades has fundamentally transformed this view, establishing gut health as a central pillar in the development of any and every chronic diseases and overall well-being. A key revelation has been that the gut microbiota is not just a passive community but an active mediator of health. The transfer of microbiota can effectively transfer disease phenotypes, opening revolutionary avenues for therapeutic intervention.
In alignment with this paradigm shift, our research group focuses on the intricate relationship between the intestinal microbiota, metabolism, and the metabolome the "3M Interactions". This approach allows us to dissect the fundamental molecular dialogues between the host and its microbial residents. Furthermore, we extend this investigation to dietary micronutrients. Recognizing that the health benefits of these compounds are often microbiota-dependent, we explore the critical role of their microbial metabolites.
Collectively, our research broadly revolves around the phrase, it takes ‘guts’ to stay healthy!
The great hopes of the pre-genomic period to define human behavior, disease susceptibility, and decode the aging process through the study of human genomics or establishing the functional features of the huge non-coding area of the genome have not been very fruitful. Instead, mounting evidence points to environmental variables (such as nutrition and lifestyle) as having a significant impact on the host's phenotypic plasticity. Recent advances in the health sciences have shown that the metagenome of human gut bacteria is susceptible to environmental influences, which in turn can have an impact on human health and disease. In fact, the human body is becoming more and more recognized as a 'holobiont', with mutually interacting host and microbial elements. A secure and nutrient-rich environment is provided by the intestinal lumen for microbial colonization, which plays a significant role in determining human health and disease and is often symbiotic in nature. A plethora of studies in the past two decades has demonstrated the integral role of gut microbiota in human evolution, immune homeostasis and autoimmunity, neuromodulation, organ development and functions, aging and longevity, long-term risk of death, disease risk, infectious or con-communicable disease, social behavior, mood, emotion, temperament, personality traits, and sexual desire.
The research themes of our lab can be broadly classified into:
Identification of gut microbial and metabolomic signatures associated with chronic metabolic disease.
Understanding the reciprocal interaction between drugs and microbiota that dictates metabolism, bioavailability, and bioactivities.
Defining the liver and intestinal-level immunometabolic processes associated with the pathogenesis of chronic metabolic disease
Development of micronutrient-based prophylactic strategies by targeting the immunometabolic mediators along the gut-liver axis
Last update: 24.02.2026
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