Evolutionary Study of Nucleotide Preferences in Avian and Mammalian Genes

⿃類與哺乳類基因核苷酸偏好之演化研究

林詩軒

Arete Honors Program, National Young Ming Chiao Tung University

This research delves into the evolutionary differences in nucleotide preferences, specifically GC andAT frequencies, between birds and mammals. Utilizing data from THE GENE ONTOLOGYRESOURCE, which includes information on 18,372 genes across 57 species, the study examines the relationship between phylogenetic closeness and gene nucleotide preferences. The research process entailed data analysis and trend interpretation, focusing on comparing GC3 frequency usage between humans and other species, as well as the occurrence and GC3 frequency variance of specific genes in birds and mammals. Preliminary findings reveal a correlation between phylogenetic proximity and similarity in GC3 frequency usage among genes, highlighting significant discrepancies in gene sequences between birds and mammals. Although limitations in data collection may affect the accuracy of these results, the report suggests further statistical analysis to confirm these observations. This investigation not only offers new insights into the differences in gene preferences during the evolutionary process but also lays the groundwork for future exploration of gene conservation features across specific species. The study aims to deepen our understanding of evolutionary relationships and the role of genes across different species, potentially applying this knowledge to broader fields within evolutionary genetics.