蔡佩汝

Teresa received her B.S. degree in Chemical engineering from Feng Chia University in 2020. After getting her B.S. degree, she then joined NYCU Institute of Biomedical Engineering in 2020 where she worked with Professor Ethan I. Lan (Professor of Department of Biological Science and Technology of National Yang Ming Chiao Tung University) on the development of microbial cell factory for flavonoids production. After completing her M.S. degree, she continued her work with Professor Ethan Lan on the metabolic engineering of microbial platforms.

Metabolic engineering of cyanobacteria for muconic acid production from CO2

Teresa P. Tsai1 , Ethan I. Lan 1

1College of Biological Science & Technology , Institute of Molecular Medicine and Bioengineering

National Yang Ming Chiao Tung University

Given the challenge of climate change, reducing carbon dioxide concentration has become a priority. One potential solution is to harness the abilities of auxotrophic cyanobacteria to utilize carbon dioxide as a sole carbon source to produce valua ble chemicals. To this end, we have conducted metabolic engineering of Synechococcus elongatus PCC 7942 to synthesize muconic acid from carbon dioxide, which is a key precursor for the production of plastic monomers such as adipic acid, polyethylene tereph thalate (PET), and Nylon 6,6. These products have significant market value, with adipic acid, PET, and Nylon 6,6 having market sizes of 6.4 billion USD, 58 billion USD, and 5.3 billion USD, respec tively. Through overexpression of heterologous genes in Synechococcus elongatus PCC 7942, we have achieved a muconic acid titer of 150 mg/L/OD, making us the first group to successfully utilize carbon dioxide for muconic acid production.

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