Lidocaine is metabolized predominantly and rapidly by the liver, and metabolites and unchanged drug are excreted by the kidneys 10,7. Biotransformation includes oxidative N-dealkylation, ring hydroxylation, cleavage of the amide linkage, and conjugation 10,7. N-dealkylation, a major pathway of biotransformation, yields the metabolites monoethylglycinexylidide and glycinexylidide 10,7. The pharmacological/toxicological actions of these metabolites are similar to, but less potent than, those of lidocaine HCl 10,7. Approximately 90% of lidocaine HCl administered is excreted in the form of various metabolites, and less than 10% is excreted unchanged 10,7. The primary metabolite in urine is a conjugate of 4-hydroxy-2,6-dimethylaniline 10,7.
Now that Microsoft Authentication Libraries (MSAL) is available, we'll no longer add new features to the Azure Active Directory Authentication Libraries (ADAL) and will end security patches on June 30th, 2022. For more information on how to migrate to MSAL, refer to Migrate applications to Microsoft Authentication Library (MSAL).
Quite possibly The Cutest Thing in the History of Cute Little Things, the NeoPixel FeatherWing is is 4x8 pixel matrix that fits perfectly atop any of our Feather microcontroller boards.
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