Image: Fitness landscape for an objective function with multiple minima
We are interested in how cells work at the systems levels, especially metabolic and protein signaling pathways.
The long-term objectives of the labs are:
1. Develop techniques to create reliable quantitative mechanistic models of cellular pathways can could be useful in the clinic.
2. Develop computational tools and standards in qualitative systems biology.
Leading the Center of Reproducibility in Biomedical Modeling.
Developing predictive mechanistic models of EGF signaling in cancer.
Developing high-performance computing environments for desktop and cluster environments.
Developing user tools for modeling and analysis of pathways.
developing new modeling strategies for complex systems.
Understanding the operational characteristics of cellular pathways.