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Research Vision
Many biological processes cannot be fully understood from static structures alone. Proteins and biomolecular assemblies often function through transient conformational changes, weak interactions, dynamic self-assembly, and mechanical responses to their environment. These events are frequently heterogeneous, short-lived, and difficult to synchronize, making them challenging to capture using ensemble measurements.
The Lin Lab aims to bridge this gap by developing and applying approaches that allow us to watch biological molecules work in real time. Our long-term vision is to establish HS-AFM and integrated biophysical analysis as a quantitative platform for understanding how molecular structure, dynamics, mechanics, and function are coupled in living systems.
About Us
The Lin Lab is a biophysics lab at the Department of Chemistry, University of Texas at Austin. Lin group members come from all over the world, and we value having people from many different backgrounds.
Our Research
We develop High-Speed Atomic Force Microscopy (HS-AFM) to visualize real-time biomolecular dynamics at the single-molecular level. Current lab interests include the structural and functional dynamics of membrane proteins, protein-DNA interactions, and viral proteins.
The Team
In the Lin Lab, you will find a vibrant and dedicated team of single-molecular biophysicists. We are actively looking for highly motivated postdoctoral researchers, graduate students, and undergraduate students who are interested in biophysics, molecular & structure biology, biomedical engineering, and computer science.
Contact Information
Dr. Yi-Chih Lin
The University of Texas at Austin
100 E. 24th Street
Welch 3.212 (Chemistry office)
Welch 4.214 (Office)
Welch 4.262 (Lab)
Welch 2.204 (Delivery)
AUSTIN, TX 78712
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