Search this site
Embedded Files
IWOMB 2025
  • HOME
  • PROGRAMME
  • BOOK OF ABSTRACTS
  • SPEAKERS
  • WORKSHOPS
  • VENUE
  • GALLERY
  • COMMITTEES
IWOMB 2025
  • HOME
  • PROGRAMME
  • BOOK OF ABSTRACTS
  • SPEAKERS
  • WORKSHOPS
  • VENUE
  • GALLERY
  • COMMITTEES
  • More
    • HOME
    • PROGRAMME
    • BOOK OF ABSTRACTS
    • SPEAKERS
    • WORKSHOPS
    • VENUE
    • GALLERY
    • COMMITTEES

Eduardo R. Mendoza

Corresponding Member

National Academy of Science and Technology


Adjunct Professor

Mathematics and Statistics Department

De La Salle University

Plenary Title

Concentration Robustness and 

Concordance of Biochemical Systems

Abstract

The goal of the talk is to discuss the benefits of realizing ODE models of biochemical systems as kinetics systems. This approach involves constructing a chemical reaction network (CRN) from the model´s biochemical map or “cartoon” and assigning a kinetics or rate function to each reaction which together result in the same ODE system. This “decoupling” of a dynamical system enables the distinction between network-dependent and network independent (or kinetic) properties. Concentration robustness, a kinetic property introduced by G. Shinar and M. Feinberg in 2010, has led to novel insights about the robustness of biological systems. We present some recent results in our comparison of insulin signaling in healthy and T2D (type 2 diabetes) cells. Concordance on the other hand, is a network property which impacts the stability of equilibria of a wide class of dynamical systems. We again use a widely used model of insulin signaling in healthy cells to illustrate this novel system property. It is interesting to note that cocordance was abstracted from the behavior of a CFSTR (Continuous Flow Stirred Tank Reactor), a popular model in chemical engineering. 



This event is organized by the Philippine Society for Mathematical Biology.For concerns and inquiries, email: iwomb2025.psmb@gmail.com
Report abuse
Page details
Page updated
Report abuse