Amy R. Dwyer, Ph.D.

Role: Postdoctoral Associate

Graduate: University of Western Australia

Department of Medicine and Pharmacology

Undergrad: University of Western Australia

Majors: Physiology and Pharmacology (Honors)

Awards & Honors:

  • Interim Undergraduate Scholarship, University of Western Australia (2010-2011)
  • PhD Top-Up Scholarship, University of Western Australia (2013-2016)
  • Student Bursary Recipient, Fifth Annual Margaret River Region Forum (2014)
  • Future of Science Fund Scholarship Recipient, Keystone Symposia (2016)
  • UMN CTSI Translational Research Development Program Postdoctoral Fellow (2019-2021)

Research Interests:

Every year in the United States over 1 million breast biopsies are performed and 10-20% of these biopsies result in a diagnosis of invasive breast cancer. Breast cancer is the second leading cause of cancer death in women, and most deaths result from resistance to therapy and cancer spread to other organs/tissues. My research in the Lange lab focuses on steroid and growth factor receptor signaling as part of unexpected or unique transcriptional complexes. Therapeutic strategies aimed at targeting the “social network” of steroid receptors may prove to be highly efficacious as part of modern therapies to overcome resistance and prevent cancer spread.

Highlighted publications:

Sullivan AR* and Pixley FJ. (2014) CSF-1R Signaling in Health and Disease: A Focus on the Mammary Gland. J Mammary Gland Biol Neoplasia 19: 149-159.

Dwyer AR, Mouchemore KA, Steer JH, Sunderland AJ, Sampaio NG, Greenland EL, Joyce DA, Pixley FJ. (2016) Src family kinase expression and subcellular localization in macrophages: implications for their role in CSF-1-induced macrophage migration. J Leukoc Biol 100(1): 163-175

Dwyer AR, Ellies LG, Holme AL, Pixley FJ. (2016) A 3D co-culture method to investigate macrophage-dependent tumor cell invasion. J of Biol Methods, 3(3).

Dwyer AR, Greenland EL, Pixley FJ. (2017) Promotion of Tumor Invasion by Tumor-Associated Macrophages: The Role of CSF-1-Activated Phosphatidylinositol 3 Kinase and Src Family Kinase Motility Signaling. Cancers, 9(6), 68.

McGonigle TA, Keane KN, Ghaly S, Carter KW, Anderson K, Scott NM, Goodridge HS, Dwyer AR, Greenland EL, Pixley FJ, Newsholme P, Hart P. (2017) UV-irradiation of skin enhances glycolytic flux and reduces migration capabilities in bone marrow-differentiated dendritic cells. Am J Pathol, manuscript accepted.

McGonigle TA, Dwyer AR, Greenland EL, Scott NM, Keane KN, Newsholme P, Goodridge HS, Zon LI, Pixley FJ, Har PJ. (2017) PGE2 pulsing of murine bone marrow cells reduces migration of daughter macrophages associated with chronic graft versus host disease. Exp Hematol, manuscript accepted.

Truong TH*, Dwyer AR*, Diep CH, Hu H, Hagen KM, Lange CA. Phosphorylated progesterone receptor isoforms mediate opposing stem cell and proliferative breast cancer cell fates. Endocrinology. 2018 Dec 28. doi: 10.1210/en.2018-00990. *These authors contributed equally.

*indicates maiden surname

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