Finzel Research Group
The Finzel group is engaged in structural biology research aimed at accelerating the development of medicinal agents and specific inhibitors of drug targets to advance the understanding of disease control. Research interests cover a wide range of possible therapeutic interests, including antbacterial and anticancer drug discovery and structural bioinformatics.
We utilize protein crystallography and biophysical methods to study the binding of small-molecule inhibitors to potential drug targets. See the Research tab for a list past and current of projects. Our laboratory on the ground floor of Weaver-Densford Hall on the Twin Cities Campus (East Bank) of the University of Minnesota is well-equipped for protein chemistry necessary to over-express and purify proteins, and to crystalize and investigate protein structure by analysis of X-ray diffraction. We often utilize the synchrotron X-ray sources at the Advanced Light Source in Berkeley, CA (Beamline 4.2.2 of the Molecular Biology Consortium), and the Advanced Photon Source innArgonne IL (Beamline 17-ID IMCA-CAT) for diffraction experiments.