Week 3 News
(Writers' Corner)
All content is written, photographed, and edited by our amazing COSMOS students!
(Writers' Corner)
Residential News By: Ansh S.
With the summer sunshine shining down on Argo Hall, Cluster 8 excitedly woke up to a crisp and bright Thursday morning! Excited and anticipating the coming weekend, Cluster 8 got ready to fill up on some nutrients before they started the day.
After breakfast, Cluster 8 headed to their classes. As the looming deadline for the ethics projects approached, Cluster 8 anxiously worked on their projects and lab experiments throughout the day. Even after class ended and the group headed to lunch, many groups met together during lunch, sharing plans and ideas over noodles, pizza, and fruit bowls!
Some people felt it to be surreal when class ended at 4 o’clock. Everyone was so intensely focused on their classes and the activities they had to do that it seemed that nobody was ready to go back to do the nightly programs! Many groups agreed to meet up at Price Center, studying and reciting their well-thought-out videos over frozen yogurt and boba. Other groups explored other options, such as heading to 64 Degrees to do group sing-alongs or go on group runs together around Revelle!
Night fell, and Cluster 8 was more than happy to reenergize themselves with some of the amazing food options fwm 64 Degrees! Some were already stuffed, having eaten food from one of the various eateries around UCSD! Some got tteokbokki and ramen from Target, while others got Mediterranean food from Santorini Greek Island Grill in Price Center and Boba from 6th College’s Fan-Fan! Regardless, everyone had their bellies full as they headed to the nightly programs.
This night, the myriad of nightly programs included volleyball, with RAs finally bringing out a real net for all of the students to utilize, hot pot for the creatives who wanted to try their hand at cooking, bead keychain making, and many Minecraft related activities as well. Cluster 8 had a blast!
Tired out from the day, Cluster 8 headed to bed, but not before hanging out with their suite–playing Among Us, basketball, or card games–and also adding the finishing touches to their ethics projects! Thursday was a very productive day for Cluster 8.
Cluster News By: Jiwon R.
Today was Cluster 8’s second day of field trip! As they did a week ago, students pulled up the closets and grabbed their sky blue COSMOS t-shirts, then headed down to 64 Degrees to fill up their growling stomachs. After a graceful meal of french toast, yogurt bowls, and scrambled eggs, Cluster 8 lined up on the plaza and headed down to the same old Powell-Focht’s headquarters. Upon arrival, they were greeted by their teacher fellow Dr. Steinbach as well as some of their CAs (Cluster Assistants). Beloved Dr. Sah and Dr. Gaetani would be joining them on the bus shortly.
When everyone was secure in their own zones in the yellow school bus, off they went to Gilead! The road to Oceanside consisted of spirited dialogues, games of Clash Royale, and sweet naps facilitated by the rattling of their cushioned seats. As the windows serially filled with images of the sea, houses, trees, apartments, across could be seen a green sign reading “Oceanside,” and later the words “GILEAD” topped off with a red feather logo. They’ve arrived!
Hopping off the bus, students were greeted by Gilead staff. Names were called out, and each person received a lanyard with a red chord–matching the color of the logo. There was one drama before heading into the lab, though, in which their newsletter editor Jiwon forgot to wear long pants and cried as she was threatened by the possibility of being unable to enter the labs. However, kind staff handed her extra scrubs (it looked a little silly.. but better than nothing), and everyone was soon set to go!
Cluster 8 students, CAs, and professors were split into smaller groups and given a tour around Gilead labs. Of course, they were provided with proper PPE–lab coats and safety goggles–before entering the labs. Sadly, pictures weren’t allowed in these places, so students filled their eyes with every precious scene and space and fully immersed themselves in the opportunity that would not come again. As each Gilead scientist walked students through the various devices, drugs, and cell cultures born in the labs, the young COSMOS scientists asked questions and shared comments about the most intriguing parts. The tour was slightly over an hour, and was tied up by a group photo in front of the building.
Today was also a special day in that it felt like a ‘real field trip’: Cluster 8 was getting packed lunch at Gliderport!! The yellow school bus once again rattled down south and reached the edges of UCSD campus, the edges of the continent. As students jumped off the bus, they grabbed their lunch of choice one by one–and walked together towards the intersection of sky and water. The more they approached the shore, the more gliders there were–comfortably dangling from colorful parachutes. Cluster 8 students clustered themselves along a long wooden bench facing the beach, and grabbed their ham & cheese sandwiches, chips, and quinoa salad bowls. There wasn't enough space, so some sat on the ground–enjoying the sand attach to their bottoms. After the meal, everyone climbed down to the photo spot and took pictures altogether while Dr. Steinbach urged them to “wrap it up.”
The bus had left at the time they were dropped off at Gliderport, so students happily walked back to the Bioengineering Building, talking about the experience at Gilead, chomping on leftover Grandma cookies, and teaching each other “useful words” in Hindi, Korean, Mandarin, and Spanish.
All hyped and sweaty, students entered the computer lab for the final schedule of the day: introduction to their final project! Students multi-tasked on fanning each other and paying full attention to Dr. Sah and Dr. Gaetani’s explanation for the five project options. Students would eventually be split up into five groups with five people in each, since Cluster 8 had an ideal population of 25 students. After the introduction, 4 o’clock approached very quickly, so Cluster 8 spent the rest of the time winding down from the tiresomeness of the field trip and poking each other to find out their project choices. It was a day full of activities, full of memories, and of drugs, sweat, and tears.
Cluster News By: Jiwon R.
Half of COSMOS has passed by already. Now, Cluster 8 was walking into the second half, the third quarter. Breakfast times had shifted by floor. So did time for dinner. Closing day vaguely roamed in front of the sleeping faces, like a ghost, throughout the cloudy dawn of Revelle. The drain of time might have made students sad, disappointed, or even thrilled, but today was not the day to sit alone sentimentally. At least, not yet..
It was project day!
Entering the familiar computer lab at Powell-Focht Bioengineering Hall, students dispersed throughout the rows of desks and computers–seating themselves next to comfortable faces and smiles. Muffled voices occasionally discussed their choices of projects, as they awaited their official first day of working on the final COSMOS project.
Students were first given the task to brainstorm and summarize each project: the row upfront would summarize project 1, the second row would summarize project 2, and so on. After a brief time of refreshing their miscellaneous memories on their professors’ diagrams and explanations last friday, it was time. Dr. Steinbach posted a google spreadsheet on google classroom, and students’ names spilled into each of their aspirations. Sure, some projects were more popular than others–such as project 4 and project 1–but overall, the distribution was fairly even.
With the long list of names and numbers in parentheses, Dr. Steinbach worked to arrange students in the appropriate groups for the next hour. In the meantime, students added last touches to their ethics presentation, and crammed on the posted material about RNAi drugs. Dr. Gaetani entered the room shortly after, and gave a short lecture on how to read research papers–walking through the paper he wrote a few years ago. While students eagerly asked questions after the lecture (ranging from why he chose to dedicate his career to research to his post-study summer vacations), the spreadsheet displayed the all-awaited result: their project groups. Some were happy, some were disappointed, and some let out gladful or pitiful sighs–but most people accepted their own fate and greeted themselves to their new teammates.
In the afternoon following lunch, each team dispersed throughout the first floor of the Focht-Powell Bioengineering Building and discussed the project plan with their awesome CAs (Cluster Assistants). Sounds of typing, laughing, and passionate discussions echoed throughout, and everyone was ready for the new week.. together.
Residential News By: Claire D.
After an eventful and exciting night of gambling, Cluster 8 woke up on Monday for their 3rd week of classes. Today was resented by some, because today, the sleeping schedule was swapped. Those, such as my suite, who got to breakfast later the first two weeks could wake up at 7:30 am and be ready by 8:00-8:10. However, on Monday, we had to wake up at 7:00 to leave at 7:40 instead… but, in a tradeoff, those who wake up earlier now have time to explore breakfast options and eat more leisurely before class.
For example, some Cluster 8 students ventured to the back of 64 degrees to discover brioche-like toast with butter and jam. It was quite delicious - what a find!
At lunchtime, we gathered in front of the bioengineering building and rushed along our now well-known path to get food at 64 degrees. It was yummy, as always. Some Cluster 8 members are also starting to branch out, now that we’ve officially reached the halfway point. Pizza was tried, pasta was considered, tacos tasted, among other food types that certain Cluster 8’ers have yet to try.
The activities of the night were zine creation, volleyball, friendship bracelets and a trip to price center. These chill events were super helpful to decompress after a packed Monday coming back to classes!
Daily Questions!
1. Why have you picked this project? What are you most excited about, coming into it?
2. What have you guys done today?
3. What is the most surprising or interesting thing you have learned from your project so far?
Cluster Interviews By: Jiwon R.
Stephy, Project 1
1. I picked this project because I was really interested in making cartilage, and compressing the gels to make these. I’m most excited about seeing if the cells will survive under different levels of compression.
2. Today, we–Nubia, Junior, and I–practiced making gels. And we pipetted a lot of substances into the gels. We will be compressing them tomorrow!
3. One aspect that interested me the most is that we’re able to mimic cartilage by compressing the rat tail collagen gel. I think it will be really cool!
Merielle, Project 2
1. I chose this project because I was really interested in how this specific bioreactor worked, and I also thought it’d be cool how the physical and environmental components will affect the cells. In general, project 2 appealed to me the most!
2. Mostly, we did a lot of procedure and literature reading. It is a little difficult right now because our CA Albert hasn’t been able to get complete clearance on every detail of the project. But we definitely got a lot of reading done, and I’ve learned a lot of protein names.
3. It has been interesting in general to read all the literature out there! I read a lot about the synoviocytes, and learned that there are two different types with varying functions–which I didn’t know about previously.
Jiwon, Project 3
1. I picked this project because I was interested in fluorescent microscopy. So when I was told by Dr. Gaetani that we’ll be doing a lot of staining, I decided to change my first choice to this one; it wasn’t even in my top 3 choices before LOL. I’m especially excited for the live/dead assays–and to see the red and green cells!!
2. We mainly worked on our study documents in the morning, figuring out the protocols for the pilot gel experiment in the afternoon (testing out our micropipetting skills). There was one unexpected event, though: when we came back from lunch, our CA Ava told us that we had major changes to the project, and we pretty much had to start all over again from scratch. I was in (genuine) despair when I first heard that, but I got better as we figured things out together. I felt that the emergency facilitated our team to bond!
3. Our project is creating artificial synovium out of collagen gel, so one thing that we keep in mind is that we must be really precise with our pipetting. Synovium is very very thin—meaning that we have to make our gels very very thin as well (0.5 mm) Also, we must not mess with our collagen, because they are quite expensive (no pressure on our gel-making group! :))
Ryan, Project 4
1. I chose this project because during lectures with Dr. Gaetani, the lesson about cell differentiation interested me the most. So when I heard about the project and its function with differentiation, it immediately became my first choice. I’m most excited to see the chondrocytes turn into osteoblasts, especially because it hasn’t been widely researched yet!
2. We passaged cells–in other words, grew them–and we started making gels to put in these cells so we can measure and incubate them. Hopefully, they will differentiate later on this week.
3. From the research article analysis, my partners and I learned that even scientists don’t know much about this topic–which showed us that research is really broad, and not many areas have been explored yet. It’s pretty cool to know that we can be a part of this journey.
Paola, Project 5
1. I picked this project because from the start it peaked my interest. I’m most excited to work with the hydrogels with cells and analyze the catabolic responses to exogenous IL-1.
2. Today, we worked in the lab preparing the agarose gel and inserting them into a mold made of a teflon sheet and glass slides. After we refrigerated them, we unmolded them, punched disks from the solidified gel, and placed them in well plates with PBS.
3. The most interesting thing I’ve learned from my project so far is how important aggrecan is to the function of joints in our body.
Residential News By: Claire D.
Tuesday morning served to solidify cluster 8’s new morning routines! After a delicious breakfast of more yogurt, granola, toast, fruit, pancakes, etc. Cluster 8 met up in the courtyard to head off the class together. This was an exciting morning, since many groups were looking forward to the lab work later that day!
Lunch was fairly routine as well - we headed out a little later than usual, and had to step on it rushing to 64 degrees. Lunch included enjoying lentil soup, chicken tenders, fried rice from Wok This Way, among other good alternatives on our lunchtime menus. Then, back to the lab!!
After dinner, we had an interesting day - instead of the normal activities we had a block for Minecraft Mania. Basically, we had many activities to choose from, but everything was heavily minecraft themed! We could do temporary tattoos of creepers, baby chickens, enderman and many other minecraft creatures, or we could shoot bows and arrows at “end crystals,” or even “PVP” with pool noodles, among other fun and creative activities. Everyone was collected on the courtyard for this time, and it proved to be a whole lot of fun, as Cluster 8 dispersed and melded together in the big soup of excited COSMOS kids.
Daily Questions!
1. Have you made a lot of progress so far?
2. What has been the funniest moment or the biggest mistake that’s happened?
3. How is the team dynamic as of now, and how well do you guys work together?
Cluster Interviews by: Jiwon R.
Anwita, Project 1
1. We’ve made our gels and set them, so tomorrow, we will do a couple assays and start compaction so we can see if our cells are alive or not.
2. One mistake that happened was that we didn’t have enough collagen gel today to make all of our samples, and we lost some along the way while pipetting.
3. The team dynamic is really nice because we know how to divide up the work evenly, put in a lot of effort, and made sure that we are efficient in our tasks. Our CA Gaya is really sweet and helps us out a lot, too!
Sam, Project 2
1. We’ve made our gels and set them, so tomorrow, we will do a couple assays and start compaction so we can see if our cells are alive or not.
2. I think the biggest mistake we’ve made is letting Ansh work with the most important part of the lab (no offense ^_^). Before, everyone else worked on the cell passaging and preparation—and at this point, we think that letting Ansh to work wasn’t the most ideal choice, as he made a slight error along the way.. But other than that, I think we’re cool! Hopefully, the error isn’t too dramatic.
3. The team dynamic is awesome. We split up the work super well: Merielle and I work on the methodology and study documents; Abby and Asa has been working on the flow charts; Ansh is working on the backgrounds! The team bonding is also really good—we all went to price center together and got boba. Apparently, Abby’s bad with spicy food, so Ansh and I ate spicy fried chicken together!
Katelyn, Project 3
1. So far, it’s been a little rough because we had to change our project twice.. Initially, it was a really cool project simulating the interphase of bone and cartilage, but that approach was not feasible—so we had to switch over to another project where we are modelling the synovium. It’s still really cool, but overall we made many tweaks, and had to re-do some of our study plans. It’s going well though! We thawed and imaged cells yesterday, so the ball is rolling!
2. Going back to what I said previously, I think the biggest mistake was having to restructure the project multiple times. It was a little bit confusing and frustrating at times.. But I think it’s going to work out!
3. The team dynamic is awesome–I really like my team! I feel that we all have a really good idea about time management and distribution of tasks. Everything is working out, and it’s really fun to be in group 3 :)
Claire, Project 4
1. We’ve seeded and cultured our cells; we started by taking our surface-level chondrocytes and our deep mineralized chondrocytes, and now we have all of them seeded in our gels–of both high and low stiffness–which we made on the first day. Now they’re chillaxing in there! And yesterday, we did our first live/dead assay–where we check under the microscope for fluorescent lights to see if they were living or dead–and the results came out pretty well. In fact, Dr. Gaetani told us that it’s been one of the best he’s seen at COSMOS! We had to rush at the end because it took longer than expected, but it was a lot of fun overall.
2. To be honest, we haven’t had many mistakes so far, thankfully! A funny moment, though, was that we were supposed to be in the hood this morning.. But instead we had to go in the afternoon because we’d have to go after lunch when Dr. Gaetani approves our experimental design. There weren’t enough hoods at the moment, so we had to “do” the process upstairs through a zoom tour on GroupMe with our CA Sophie. We were crowded around my laptop for a good 30 minutes to watch her do stuff upstairs, and we got a little tour and met all the people upstairs working at Dr. Sah’s lab. It was really cool!
3. I think the team dynamic is great. We’ve got the synergy.. Love Sophie–best CA ever.. She loves us too, it’s great. The energy is always up, but we also have space to chillax!
Justin, Project 5
1. So far, we haven’t been able to get anything done in lab because other groups are being pretty greedy with all the hoods :) Right now, we’re working on the presentation, and we hope to put all into a poster mid-time next week.
2. As I’ve mentioned, we actually haven’t gone to the lab yet.. But a funny moment was when Catherine, Paola, Nate watched White Chicks during class while Dr. Steinbach walked in. I’m pretty sure he saw us, but he probably gave up on us at this point.
3. I think we’re a really good group, and once we get into lab, we’ll bond even more while making mistakes. I have really high hopes for our presentation!
Residential News By: Ansh S.
Wednesday morning was the usual for Cluster 8. Cluster 8 was halfway through Week 3, and by now, everybody has gotten accustomed to their normal morning routines. Very few, like me, wake up at around 5:30 in the morning, just to get the whole bathroom to themselves and their morning routines. Others struggle to wake up with their alarm, having to set their alarms multiple times and just barely getting up at 7:50 in the morning.
At breakfast, some people, still struggling to adjust to the time difference, ran downstairs to gobble up some french toast and berries before the morning call time. After breakfast, students ran towards the morning lineup, just barely making it before Aaliyah dismissed Cluster 8 to head to their classes in Powell-Focht Bioengineering Hall.
During class, everyone was so nervous and anxious about their final research projects, desperate to impress Dr. Sah, Dr. Gaetani, Dr. Steinbach, and the various cluster assistants and PhD students they were working with. Students were in desperate need to catch a moment to decompress between classes, so lunch was a much-needed break for everybody! Students loaded up on tomato pasta, noodles, Korean BBQ chicken, and pizzas, and they tried a newer, unique combination of eating a vanilla soft serve with a brownie on the side. After eating their body weight’s worth of calories, they were super excited to head back to class to continue working on their projects!
The end of class could not have come any quicker for the students of Cluster 8, and many groups decided to bond over their shared goals and study together at 64 Degrees, or Blue Pepper, or Tapioca Express at Price Center! Students excitedly gathered together once again at 6 PM, however, to enjoy dinner together before they headed to their nightly programs!
This night, there were a variety of activities for the students to enjoy. From cooking cultural dishes to playing ping pong to playing Family Feud, people could even enjoy a tea party or enjoy sports like volleyball and badminton!
After enjoying suite time, it was finally time for Cluster 8 to go to bed. They gratefully welcomed sleep, and they were pumped to see what tomorrow awaited.
ㅜ무뎌ㅜ ㅏㄷㄴ다ㅑ (Type in English to understand). ;)