Aakash Saha

PhD Student

University of California, Riverside

Email: asaha011@ucr.edu

About me

Greetings, esteemed reader. I'm Aakash Saha, a graduate student researcher in the Palermo Lab. My academic journey began with an undergraduate degree in Biotechnology from India, propelling me towards a deeper exploration of my passion for research. This quest led me to the University of California, Riverside, where I enrolled in a doctoral program. While my initial focus was on molecular biology and animal cell culture, my doctoral studies prompted a shift in gears, directing my attention towards scrutinizing protein molecules at the atomic level through a computational lens.

Currently in the final year of my graduate studies, my research is dedicated to unraveling the intricacies of CRISPR-Cas systems. I leverage state-of-the-art computational tools and employ multi-scale classical and enhanced molecular dynamics approaches to comprehensively understand these biological mechanisms. Beyond this, I am intrigued by the application and refinement of the latest machine learning models to harness the wealth of simulation data generated, seeking efficient ways to analyze this data.

As I approach the culmination of my academic journey, I am actively seeking positions for future endeavors in the realms of CRISPR-Cas, Computational Chemistry, and Data Science. I invite you to peruse my profile, and I am enthusiastic about the possibility of connecting with you for potential opportunities.

 

Current Research

Bacteria and prokaryotes employ a sophisticated defense mechanism—the CRISPR-Cas system—to fend off foreign nucleic acid invasion. Among these systems, the Cas12a nuclease has emerged as a key player, showcasing groundbreaking applications in rapid nucleic acid detection, notably in the identification of SARS-CoV-2. Operating at the molecular level, Cas12a's unique ability to cleave double-stranded target DNA using a single catalytic domain hinges on crucial conformational changes within the protein. However, unraveling the intricacies of this transition remains a significant challenge.

My current research is dedicated to unraveling the mysteries of the CRISPR-Cas12a system. Leveraging cutting-edge computational tools and employing multi-scale classical and enhanced molecular dynamics approaches, I aim to decode the elusive mechanism of conformational transition. The goal is twofold: to enhance our understanding of the CRISPR-Cas12a system and to lay the groundwork for protein engineering strategies. This approach seeks to optimize the system's functioning, contributing to the revolutionary field of genome-editing technology. Ultimately, this research carries the potential to instill hope in millions of individuals, paving the way for a brighter future for them and their loved ones.

 

 

Contact me

Feel free to email me for questions, project feedback, or just to say hello.

Resume: Link

CV (Detailed): Link

Email: asaha011@ucr.edu

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