Electrodiagnostics

A medical test is "a characteristic, measurement, observation, or medical procedure made on a person that provides information that relates to some aspect of their health state." (Cochrane Collaboration, DTA Handbook)

An electrodiagnostic test is a type of medical test that uses a physiological measurement to assess the bioelectric properties of nerve and muscle tissue to assess their health. These are also known as electrophysiological tests and include: ECG, EEG, and EMG.

Purpose

Our research evaluates the use of electrodiagnostic tests for a variety of purposes:

Screening, to detect early subclinical changes of nerve and muscle health
Diagnosis and Staging, to determine likelihood of a particular condition and if present how advanced the condition is
Prognosis, to estimate the rate of progression of a condition on an individual basis
Therapeutic Response, to determine if there is a change in the condition after starting a therapeutic intervention

Nerve Excitability Test

A comprehensive test of the electrical health of nerves. Our web application allows comparison with International Normative data. The International Consensus Guidelines (2020) are an important resource.

Meta-analysis for diagnostic use in ALS

Decreased excitability of motor axons contributes substantially to contraction fatigability during neuromuscular electrical stimulation

Feasibility of an international normative database for nerve excitability studies

Nerve excitability differences in slow and fast motor axons of the rat: more than just Ih

Motor axon excitability measures in the rat tail are the same awake or anaesthetized using sodium pentobarbital

MScanFit MUNE Multicentre Trial

MUNE stands for motor unit number estimation; simply, it is an attempt to count the number of motor axons connected to a muscle. The goal is straightforward, but there are many proposed methods. MScanFit is a relatively new method still being tested.

Fifty Years of Motor Unit Number Estimation

Assessing inter-rater reproducibility in MScanFit MUNE in a 6-subject, 12-rater “Round Robin” setup

Estimating motor unit numbers from a CMAP scan: Repeatability study on three muscles at 15 centres

Impact of reference electrode position on motor unit number estimation (MUNE) in the tibialis anterior muscle using MScanFit: test-retest reliability

Motor unit number estimation (MUNE): An important – though imperfect – measure receives some needed scholarship

Clinical Neuromuscular Physiology

These are a collection of other research that don't fit neatly into the two categories above.