Generic PROMs are designed to assess general aspects of health that are not specific to a particular disease (e.g., EQ-5D, SF-12/36, HUI2/3, WHOQOL, ESAS, QWB, and PROMIS), while disease-specific PROMs assess aspects of health that are specific to a given disease (e.g., WOMAC, AQLQ, EORTC-QLQ-C30, PHQ-9, PAID-5).
Generic and disease-specific PROMs each have their own advantages and disadvantages. For instance, generic PROMs are useful when comparing different groups of patients across different health conditions; however, they may be less sensitive to pick up important changes in specific aspects of health. On the other hand, disease-specific PROMs are not useful in comparing different groups of patients with different diseases; however, they are more likely to be sensitive to specific changes in health. Given these advantages and disadvantages, it is often recommended that a generic and a disease-specific PROM should be used together.
PROMs could be profile or preference-based: