The show focuses on an anthropomorphic, yellow, rectangular mouse-like creature named Wubbzy, who has various antics with his friends: Widget, a rabbit-like creature who can build; Walden, a bear-like creature who is a brainiac; and since the second season, Daizy, a dog-like creature who loves flowers. They all live in the town of Wuzzleburg, a fictional location with lots of creatures of every type, and all kinds of events are happening in it, especially with Wubbzy.