Drones, both manually piloted and autonomous, have become a massive industry and are used everywhere from Hollywood and hobbyists to military, humanitarian, and scientific applications. The primary limitations on current drones include their payload capacities, operational range, pilot skill, and requirements of launch/recovery positions. This work documents the design and development of an autonomous payload-capable drone that can take off from a single-use underwater capsule. The capsule can be secured underwater at a designated location and, on command, float to the surface and open. The drone will then take off from the surface of the water, deliver a payload, and land at an alternate location. This system can have significant advantages for military/intelligence operations, humanitarian aid missions, and scientific research. Deploying an autonomous drone this way improves security, reliability, accessibility, and response time.