Developing Treatments for Head and Neck Squamous Cell Carcinoma
SLU ID 22-027 | c-Fos over-expression head and neck cancer cells
Intellectual Property Status
Seeking
Know-how based
Tangible material
Licensee
Development partner
Commercial partner
Investment
University spin out
Background
Head and neck squamous cell carcinoma (HNSCC) is among the top six cancers by prevalence worldwide. While medical advancements have improved the quality of life for individuals with HNSCC, cures for the disease remain elusive. Regional and distant recurrence of HNSCC remains a significant problem.
Overview
Researchers at Saint Louis University have generated stable HNSCC cell lines that are useful for studying the signaling pathways that control the high incidence of local recurrence and distant metastases of the disease. The cell lines ectopically express the C-Fos gene, which makes the cells tumorigenic in nude mice.
Benefits
The potential benefits of this technology include:
Increasing understanding of signaling pathways that control local recurrence and distant metastases of head and neck squamous cell carcinoma (HNSCC)
Applications
The potential applications of this technology include:
Developing therapeutics for head and neck squamous cell carcinoma (HNSCC)
Conducting academic research on HNSCC
Opportunity
Saint Louis University offers non-exclusive licenses for use of this technology.
References
Muhammad, N., Bhattacharya, S., Steele, R., Phillips, N., & Ray, R. B. (2017). Involvement of c-Fos in the promotion of cancer stem-like cell properties in head and neck squamous cell carcinoma. Clinical Cancer Research, 23(12), 3120-3128. doi: 10.1158/1078-0432.CCR-16-2811