Provisional patent application filed
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TDP-43 protein aggregation and loss of function are hallmarks of Amyotrophic Lateral Sclerosis (ALS), frontotemporal dementia, limbic-predominant age-related encephalopathy, Alzheimer's disease, multisystem proteinopathy, and chronic traumatic encephalopathy. Currently, there are no treatments for neurodegenerative disorders linked to TDP-43 pathology.
Researchers at Saint Louis University have designed and investigated specific molecules to decrease TDP-43 aggregation and recover protein function.
The potential benefits of this technology include:
increasing the number of potential treatments for various neurodegenerative disorders linked to TDP-43 pathology.
Potential applications of this technology include developing treatments for:
Amyotrophic Lateral Sclerosis (ALS)
frontotemporal dementia
limbic-predominant age-related encephalopathy
Alzheimer's disease
multisystem proteinopathy
chronic traumatic encephalopathy
Saint Louis University is seeking a partner to further develop and commercialize this technology.