Enabling High Precision, Low Cost Deuterium-Based Universal Metabolomic Isotope Labeling

SLU ID 18-028 | Isotope Labeling for Universal Multiplexing of Metabolites

Background

Isotope labeling is a longstanding technique in mass spectroscopy which improves quantitative issues of competing ionization and allows for multiplexing of samples. These techniques are often specific to a class of metabolite such as amines or thiols. For these tags to enable quantitation, the isotopes must co-elute from the column at the same time. Currently, tags use expensive 13C and 12C to ensure co-elution because less expensive deuterium can cause chromatographic shifts.

Overview

Researchers at Saint Louis University have developed a method for using deuterium-based tagging to achieve universal metabolomic isotope labeling with high precision at low cost.

Benefits

The benefits of this technology include:

• Minimizing the cost of neucode tagging

• Increasing the precision of neucode tagging

• Increasing the efficiency of neucode tagging

Applications

Potential applications of this technology include:

• Mass spectroscopy

• Neucode tagging

• Proteomics

• Metabolomics

• Glycomics

Opportunity

Saint Louis University is seeking partners to further develop and commercialize this technology.