Enabling High Precision, Low Cost Deuterium-Based Universal Metabolomic Isotope Labeling
SLU ID 18-028 | Isotope Labeling for Universal Multiplexing of Metabolites
Intellectual Property Status
Seeking
Provisional patent application filed
Know-how based
Licensee
Development partner
Commercial partner
Investment
University spin out
Background
Isotope labeling is a longstanding technique in mass spectroscopy which improves quantitative issues of competing ionization and allows for multiplexing of samples. These techniques are often specific to a class of metabolite such as amines or thiols. For these tags to enable quantitation, the isotopes must co-elute from the column at the same time. Currently, tags use expensive 13C and 12C to ensure co-elution because less expensive deuterium can cause chromatographic shifts.
Overview
Researchers at Saint Louis University have developed a method for using deuterium-based tagging to achieve universal metabolomic isotope labeling with high precision at low cost.
Benefits
The benefits of this technology include:
Minimizing the cost of neucode tagging
Increasing the precision of neucode tagging
Increasing the efficiency of neucode tagging
Applications
Potential applications of this technology include:
Mass spectroscopy
Neucode tagging
Proteomics
Metabolomics
Glycomics
Opportunity
Saint Louis University is seeking partners to further develop and commercialize this technology.