Developing Treatments for Diseases Associated with the CLIC1 Gene
Developing Treatments for Diseases Associated with the CLIC1 Gene
Embedded Files
SLU ID 18-002 | Mice carrying a disrupted gene for CLIC1
SLU ID 18-002 | Mice carrying a disrupted gene for CLIC1
Intellectual Property Status
Intellectual Property Status
Seeking
Seeking
Proprietary non-patented intellectual property
Tangible material
Know-how based
Copyright
Licensee
Development partner
Commercial partner
Investment
University spin out
Background
Background
The physiological roles of CLIC proteins in health and disease are not well understood and remain a matter of intense debate in the scientific community. There is a need for tools that facilitate the investigation of these proteins.
Overview
Overview
Researchers at Saint Louis University have developed a recombinant mice were created in which the normal gene encoding CLIC1 (chloride intracellular channel 1) has been replace with one carrying a large deletion the inactivates the gene.
Benefits
Benefits
The potential benefits of this technology include:
Increasing the ability to investigate the function of CLIC1
Increasing the ability to develop therapies for treating diseases associated with CLIC1
Applications
Applications
The potential applications of this technology include:
Investigating animal inflammatory physiology
Opportunity
Opportunity
Saint Louis University offers this technology under a non-exclusive license.
References
References
Ulmasov, B., Bruno, J., Oshima, K., Cheng, Y. W., Holly, S. P., Parise, L. V., Egan, T. M., & Edwards, J. C. (2017). CLIC1 null mice demonstrate a role for CLIC1 in macrophage superoxide production and tissue injury. Physiological Reports, 5(5), e13169. doi:10.14814/phy2.13169. PMID: 28275112.
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