Developing Treatments for Diseases Associated with the CLIC1 Gene

SLU ID 18-002 | Mice carrying a disrupted gene for CLIC1

Intellectual Property Status

Seeking

  • Proprietary non-patented intellectual property

  • Tangible material

  • Know-how based

  • Copyright

  • Licensee

  • Development partner

  • Commercial partner

  • Investment

  • University spin out

Background

The physiological roles of CLIC proteins in health and disease are not well understood and remain a matter of intense debate in the scientific community. There is a need for tools that facilitate the investigation of these proteins.

Overview

Researchers at Saint Louis University have developed a recombinant mice were created in which the normal gene encoding CLIC1 (chloride intracellular channel 1) has been replace with one carrying a large deletion the inactivates the gene.

Benefits

The potential benefits of this technology include:

  • Increasing the ability to investigate the function of CLIC1

  • Increasing the ability to develop therapies for treating diseases associated with CLIC1

Applications

The potential applications of this technology include:

  • Investigating animal inflammatory physiology

Opportunity

Saint Louis University offers this technology under a non-exclusive license.

References

  • Ulmasov, B., Bruno, J., Oshima, K., Cheng, Y. W., Holly, S. P., Parise, L. V., Egan, T. M., & Edwards, J. C. (2017). CLIC1 null mice demonstrate a role for CLIC1 in macrophage superoxide production and tissue injury. Physiological Reports, 5(5), e13169. doi:10.14814/phy2.13169. PMID: 28275112.