Increasing the Accuracy of In Vivo Models for Oncolytic Adenovirus Vectors Using a Cotton Rat Model
Increasing the Accuracy of In Vivo Models for Oncolytic Adenovirus Vectors Using a Cotton Rat Model
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SLU ID 03-017 | Cotton Rat Model for Oncolytic Adenovirus Vectors
SLU ID 03-017 | Cotton Rat Model for Oncolytic Adenovirus Vectors
Intellectual Property Status
Intellectual Property Status
Seeking
Seeking
- Proprietary non-patented intellectual property
- Know-how based
- Tangible Material
- Licensee
- Development partner
- Commercial partner
- Investment
- University spin out
Background
Background
Using genetically modified replication-competent (i.e., oncolytic) adenovirus vectors to infect cancer cells and destroy them while having acceptable toxicity in normal tissue is a potential approach to treating cancer. Most studies in this field have investigated the efficiency of these vectors in immunodeficient mice bearing human tumor xenografts. However, this model doesn't fully address the situation in human cancer patients being treated with oncolytic adenovirus because the mouse is immunodeficient as well as non-permissive or semi-permissive for replication of human adenoviruses.
Overview
Overview
Researchers at Saint Louis University have developed a Syrian hamster model to enable the evaluation of the safety and efficacy of oncolytic adenovirus vectors for treating cancers and other diseases.
Benefits
Benefits
The potential advantages of this technology over existing solutions include:
- Increase the accuracy of in vivo models used to test the safety and efficacy of oncolytic adenovirus vectors
- Minimize the cost of testing the safety and efficacy of oncolytic adenovirus vectors
Applications
Applications
Potential applications of this technology include:
- Cancer research
- Drug delivery
- Drug development
Opportunity
Opportunity
Saint Louis University offers non-exclusive licenses for this technology.
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