Facilitating Research to Develop Treatments for Hemochromatosis

SLU ID 98-002 | A Mouse Model for Hemochromatosis with HFE Gene Point Mutation

Background

Hemochromatosis is a disorder that causes harmful levels of iron to build up in the body. If untreated, hemochromatosis can lead to iron overload that can damage various parts of the body including the liver, heart, pancreas, endocrine glands, and joints. Hemochromatosis is a rare disease with fewer than 200,000 cases diagnosed in the United States each year.

Overview

Researchers at Saint Louis University (SLU) have developed a mouse model for hemochromatosis with HFE gene point mutation. This includes a variety of strains for specific types of hemochromatosis. SLU partners with The Jackson Laboratory to distribute this mouse model.

Jackson Stock Number | Description or Nomenclature

005215 | FVB.129X1(B6)-Tfr2<tm1Slu>/J

005643 | B6.129X-Gusb<tm1Sly>/J

005644 | B6.129X-Gusb<tm3Sly>/J

008217 | B6.129S1-Car4<tm1Sly>/J

008218 | B6.129S1-Car14<tm1Sly>/J

025331 | B6.129X1-Car5a<tm1Sly>/J

025570 | B6.129S1-Car5b<tm1Sly>/J

Benefits

The potential advantages of this technology over existing solutions include:

• Increasing the effectiveness of pre-clinical trials in identifying viable treatment alternatives.

Applications

Potential applications of this technology include the development of treatments for hemochromatosis.

Opportunity

Saint Louis University licenses this technology on a non-exclusive basis and partners with The Jackson Laboratory (www.jax.org) to distribute the mouse model.