Magnetic resonance-guided high intensity focused ultrasound (MRgHIFU) is a nonsurgical method of treating tumors and diseased tissue using thermal ablation from ultrasonic waves while simultaneously utilizing magnetic resonance imaging (MRI) to locate and monitor the regions of interest. MRI has become the preferred imaging modality for guiding HIFU due to its capability to produce remarkably detailed images of anatomy while monitoring and mapping tissue temperature as treatment occurs. Over the last couple decades, MRgHIFU has become an FDA-approved, successful alternative to surgery and medication for the treatment of tumors, essential tremors, and Parkinson’s disease. This research explores the implications of future widespread use of MR-HIFU as well as its applications in the potential treatment of other neurological and psychiatric disorders and diseases.