Premenstrual changes in mood (e.g., increased irritability, sadness) have been implicated in adult depression, borderline personality disorder, and suicidality. However, little work has focused on developmental antecedents of the mood features of premenstrual syndrome (mood-PMS) or how mood PMS contributes to the emergence of psychopathology in early adolescence. 

In the adolescent brain and cognitive development (ABCD) study, a large (N~11,000), prospective, and publicly available dataset: mood PMS symptoms, self-reported pubertal development (high scores controlling for age indicate relatively advanced puberty), and internalizing symptoms (brief problem monitor - BPM) are assessed. Using mixed models we investigated relationships between mood PMS, internalizing symptoms (BPM), reported puberty, and suicidality. Girls with menarche by the 2-year follow-up are included (N=1644). 

More advanced puberty for age and increased internalizing symptoms at baseline each uniquely predicted mood-PMS (2-year follow-up). Girls with greater mood-PMS severity (2-year follow-up) were more likely to have experienced suicidal thoughts and behaviors (STBs) by 2-year follow-up and to experience emergence or worsening of anxiety/depression symptoms over the next year. 

Together these results highlight mood-PMS as a critical internalizing and SITB risk factor in early adolescence which requires further investigation. 

Dr. Katherine Luking's influence on the presentation development has been profound. Her unwavering support and guidance have paved the way for unparalleled passion in the realms of neuroscience and psychology. Through her mentorship, she has opened doors of discovery, allowing for a deeper understanding and appreciation of these fields. Dr. Luking's expertise and encouragement have not only shaped the content of the presentation but have also instilled a sense of confidence and passion in the presenter, making her an indispensable figure in the journey of academic and personal growth.