Publications & Citations

Total Publications: 157
Books : 1
Research Papers, Reports : 155
Patents: One Indian Patent, Application No: 1138/CHE/2009 (Published in Patent Journal 17/7/09)
 Papers marked are ACS journals
 

h index: 24

Citations: 1029 (As on 7th December 2011)

 
BOOK:
 
 
 
     FIRST EDITION (2007)                                                                     SECOND EDITION (2010)
 

Textbook on  Medicinal Chemistry -

 Published by Pearson Education Singapore Ltd. released in Jan 2007.

 
  
 
 
Patents:
Yogeeswari, P., Sriram, D., Kumar, A.S.K. et al., Indian Patent Application No. 1138/CHE/2009 A (18/5/2009): Novel N-Spiro substituted compounds for the treatment of epilepsy and neuropathic pain
 
Research Papers:

2012
        155. S.R. Patpi, L. Pulipati, 
P. Yogeeswari, D. Sriram, N. Jain, B. Sridhar, R. Murthy, S.V. Kalivendhi, S. Kantevari, Design, Synthesis and Structure-Activity Correlations of Novel Dibenzo[b,d]furan, Dibenzo[b,d]thiophene and N-Methylcarbazole Clubbed 1,2,3-Triazoles as Potent Inhibitors of Mycobacterium tuberculosis.  J. Med. Chem.  In Press.
        154. A. Mallika, S. Bhatnagar, A. Ravi, V.U. Jean Kumar, T.H. Manjashetty, P. Yogeeswari, D. Sriram, Novel acridinedione derivatives: Design, Synthesis, SIRT1 enzyme and tumour cell growth inhibition studies. Bioorg Med Chem Lett2012, In Press.
        153. A.V. Ramani, A. Monika, V. Lakshmi Indira, G. Karyavardhi, J. Venkatesh, V.U. Jean Kumar, T.H. Manjashetty, P. Yogeeswari, D. Sriram, Synthesis of highly potent novel anti-tubercular isoniazid analogues with preliminary pharmacokinetic evaluation. Bioorg Med Chem Lett2012, In Press.   
        152. Yogeeswari P, Sravan Kumar Patel, Ingala Vikram Reddy, Arvind Semwal, Monika Sharma, Gangadhar M, Siddarth Sai M, Sriram D. GABA derivatives for the treatment of epilepsy and neuropathic pain: A synthetic integeration of GABA into 1,2,4-Triazol-2H-one nucleus. Biomed. Ageing Pathol. 2012, In Press.
        151. Malwal SR, Sriram D, Yogeeswari P, Konkimalla VB, Chakrapani H. Design, Synthesis, and Evaluation of Thiol-Activated Sources of Sulfur Dioxide (SO(2)) as Antimycobacterial Agents. J. Med. Chem. 2012, 55: 553-7.        


2011

        150. Shanmugavelan P, Nagarajan S, Sathishkumar M, Ponnuswamy A, Yogeeswari P, Sriram D. Efficient synthesis and in vitro antitubercular activity of 1,2,3-triazoles as inhibitors of Mycobacterium tuberculosis. Bioorg Med Chem Lett. 2011 Dec 15;21(24):7273-6.

        149. Mugunthan G, Sriram D, Yogeeswari P, Ravindranathan Kartha KP. Synthetic analogues of mycobacterial arabinogalactan linkage-disaccharide part II: synthesis and preliminary screening of lipophilic O-alkyl glycosides. Carbohydr Res. 2011 346: 2401-5.

        148. Chitra, S., Paul, N., Muthusubramanian, S., Manisankar, P., Yogeeswari, P., Sriram, D. A facile synthesis of carbocycle-fused mono and bis-1,2,3-selenadiazoles and their antimicrobial and antimycobacterial studies. Eur J Med Chem. 2011, Nov;46(11):5465-72.

        147. Narang, R., Narasimhan, B., Sharma, S., Sriram, D., Yogeeswari, P., De Clercq, E., Pannecouque, C., Balzarini, J. Synthesis, antimycobacterial, antiviral, antimicrobial activities, and QSAR studies of nicotinic acid benzylidene hydrazide derivatives. Med. Chem. Res. 2011 In Press

        146. Kantevari S, Yempala T, Surineni G, Sridhar B, Yogeeswari P, Sriram D. Synthesis and antitubercular evaluation of novel dibenzo[b,d]furan and 9-methyl-9H-carbazole derived hexahydro-2H-pyrano[3,2-c]quinolines via Povarov reaction. Eur J Med Chem. 2011 46: 4827-33.

        145. Judge, V., Narasimhan, B., Ahuja, M., Sriram, D., Yogeeswari, P., De Clercq, E., Pannecouque, C., Balzarini, J. Synthesis, antimycobacterial, antiviral, antimicrobial activities, and QSAR studies of isonicotinic acid-1-(substituted phenyl)-ethylidene/cycloheptylidene hydrazides.  Med. Chem. Res. 2011 In Press

         144. Sriram, D., Yogeeswari, P., Methuku, S., Vyas, D.R.K., Senthilkumar, P., Alvala, M., Jeankumar, V.U. Synthesis of various 3-nitropropionamides as Mycobacterium tuberculosis isocitrate lyase inhibitor. Bioorganic and Medicinal Chemistry Letters 2011 21: 5149-5154.

        143. Chitra, S., Paul, N., Muthusubramanian, S., Manisankar, P., Yogeeswari, P., Sriram, D. Synthesis of 3-heteroarylthioquinoline derivatives and their in vitro antituberculosis and cytotoxicity studies. Eur. J. Med. Chem. Oct;46(10):4897-903.

        142. Gunasekaran, P., Perumal, S., Yogeeswari, P., Sriram, D. A facile four-component sequential protocol in the expedient synthesis of novel 2-aryl-5-methyl-2,3-dihydro-1H-3-pyrazolones in water and their antitubercular evaluation. Eur. J. Med. Chem. 2011 46:4530-6.

        141. Narasimhan, B., Sharma, D., Kumar, P., Yogeeswari, P., Sriram, D. Synthesis, antimicrobial and antimycobacterial evaluation of [2-(substituted phenyl)-imidazol-1-yl]-pyridin-3-yl-methanones. Journal of Enzyme Inhibition and Medicinal Chemistry 2011 26: 720-727.

        140. Narang, R., Narasimhan, B., Sharma, S., Sriram, D., Yogeeswari, P., De Clercq, E., Pannecouque, C., Balzarini, J. Nicotinic acid benzylidene/phenyl-ethylidene hydrazides: Synthesis, antimicrobial evaluation and QSAR studies. Letters in Drug Design & Discovery. 2011 8: 733-749.

        139. Rajesh SM, Perumal S, Menéndez JC, Yogeeswari  P, Sriram D. Antimycobacterial activity of spirooxindolo-pyrrolidine, pyrrolizine and pyrrolothiazole hybrids obtained by a three-component regio- and stereoselective 1,3-dipolar cycloaddition. Med. Chem. Commun. 2011 2: 626-30. Top ten most accessed articles in May (Click to find)

        138. Yogeeswari P, Menon N, Semwal A, Arjun M, Sriram D. Discovery of molecules for the treatment of neuropathic pain: Synthesis, antiallodynic and antihyperalgesic activities of 5-(4-nitrophenyl)furoic-2-acid hydrazones. Eur J Med Chem. 2011 Jul;46(7):2964-70. 

        137. Manjashetty TH, Yogeeswari P, Sriram D. Microwave assisted one-pot synthesis of highly potent novel isoniazid analogues.   Bioorg Med Chem Lett. 2011 Apr 1;21(7):2125-8.  

        136. Rajesh SM, Kumar RS, Libertsen LA, Perumal S, Yogeeswari P, Sriram D. A green expedient synthesis of pyridopyrimidine-2-thiones and their antitubercular activity.  Bioorg Med Chem Lett. 2011 May 15;21(10):3012-6.  

        135. Raju BC, Rao RN, Suman P, Yogeeswari P, Sriram D, Shaik TB, Kalivendi SV.  Synthesis, structure-activity relationship of novel substituted 4H-chromen-1,2,3,4-tetrahydropyrimidine-5-carboxylates as potential anti-mycobacterial and anticancer agents. Bioorg Med Chem Lett. 2011 May 15;21(10):2855-9.  

        134. Ranjith Kumar R, Perumal S, Menéndez JC, Yogeeswari P, Sriram D. Antimycobacterial activity of novel 1,2,4-oxadiazole-pyranopyridine/chromene hybrids generated by chemoselective 1,3-dipolar cycloadditions of nitrile oxides.  Bioorg Med Chem. 2011 Jun 1;19(11):3444-50. 

        133. Mugunthan G, Ramakrishna K, Sriram D, Yogeeswari P, Ravindranathan Kartha KP. Synthesis and screening of (E)-1-(β-d-galactopyranosyl)-4-(aryl)but-3-ene-2-one against Mycobacterium tuberculosis.  Bioorg Med Chem Lett. 2011 Jul 1;21(13):3947-50.  

         132. Raja VP, Perumal S, Yogeeswari P, Sriram D. Synthesis and antimycobacterial activity of highly functionalized tetrahydro-4(1H)-pyridinones.

 Bioorg Med Chem Lett. 2011 Jul 1;21(13):3881-4.

        131. Mugunthan G, Ramakrishna K, Sriram D, Yogeeswari P, Ravindranathan Kartha KP. Synthesis and screening of galactose-linked nitroimidazoles and triazoles against Mycobacterium tuberculosis. Eur J Med Chem. 2011 46: 4725-4732.  

         130.     Kantevari S, Yempala T, Yogeeswari P, Sriram D, Sridhar B. Synthesis and antitubercular evaluation of amidoalkyl dibenzofuranols and 1H-benzo[2,3]benzofuro[4,5-e][1,3]oxazin-3(2H)-ones. Bioorg Med Chem Lett. 2011 Jul 15;21(14):4316-9.  

        129.  Kantevari S, Patpi SR, Addla D, Putapatri SR, Sridhar B, Yogeeswari P, Sriram D. Facile Diversity-Oriented Synthesis and Antitubercular Evaluation ofNovel Aryl and Heteroaryl Tethered Pyridines and Dihydro-6H-quinolin-5-ones Derived via Variants of the Bohlmann-Rahtz Reaction.   ACS Comb Sci. 2011 Jul11;13(4):427-35.   

        128. Mugunthan G, Sriram D, Yogeeswari P, Ravindranathan Kartha KP. Synthesis and biological evaluation of sugar-derived chiral nitroimidazoles as potential antimycobacterial agents. Carbohydr Res. 2011 346: 1760-6.

       127. Banerjee D, Yogeeswari P, Bhat P, Thomas A, Srividya M, Sriram D. Novel isatinyl thiosemicarbazones derivatives as potential molecule to combat HIV-TB co-infection. Eur J Med Chem. 2011 46: 106-21. 

        126. Kantevari S, Patpi SR, Sridhar B, Yogeeswari P, Sriram D. Synthesis and antitubercular evaluation of novel substituted aryl and thiophenyl tethered dihydro-6H-quinolin-5-ones, Bioorg Med Chem Lett. 2011 21: 1214-7.         

2010

        125. Yogeeswari P, Reddy A.S.K, Arvind S, Sriram D. Novel role of GABAergic anticonvulsant compounds in alleivating neuropathic pain in two animal models, Ind. J. Pharmacol. 2010 42: 121.

        124. Monika S, Reddy, A.S.K., Arvind S, Sriram D, Yogeeswari P. Effectiveness of newer lipophilic GABA analogues against epilepsy, Ind. J. Pharmacol. 2010 42: 160-161.

        123. Yogeeswari P, Arvind Semwal, Sriram D., Ragavendran J.V., Sreevatsan, N, Monika Sharma. Antiallodynic and antihyperalgesic activities of anticonvulsant GABA derivatives in both sciatic and spinal nerve ligation models of neuropathic pain, Pharmacol. Online 2010 1: 634-647.   

        122. Sriram, D., Yogeeswari, P., Senthil Kumar P, Naidu G, Bhat P, 5-Nitro-2,6-dioxohexahydro-4-pyrimidinecarboxamides: synthesis, in vitro antimycobacterial activity, cytotoxicity, and isocitrate lyase inhibition studies. J Enzyme Inhib Med Chem. 2010 25, 765-72. 

        121. Kumar P, Narashiman B, Yogeeswari P, Sriram D, Synthesis and antitubercular activities of substituted benzoic acid N'-(substituted benzylidene/furan-2-ylmethylene)-N-(pyridine-3-carbonyl)-hydrazides. Eur J Med Chem. 2010 45, 6085-89.

        120. Prasanna P, Balamurugan K, Perumal S, Yogeeswari P, Sriram D, A regio- and stereoselective 1,3-dipolar cycloaddition for the synthesis of novel spiro-pyrrolothiazolyloxindoles and their antitubercular evaluation. Eur J Med Chem. 2010 45, 5653-61.

        119. Manikannan, R., Venkatesan R, Muthusubramanian, S., Yogeeswari, P., Sriram D. Pyrazole derivatives from azines of substituted phenacyl aryl/cyclohexyl sulfides and their antimycobacterial activity. Bioorg Med Chem Lett. 2010 20: 6920-24.

        118. Maheswari SU, Balamurugan K, Perumal S, Yogeeswari P, Sriram D, A facile 1,3-dipolar cycloaddition of azomethine ylides to 2-arylidene-1,3-indanediones: Synthesis of dispiro-oxindolylpyrrolothiazoles and their antimycobacterial evaluation, Bioorg Med Chem Lett. 2010 20: 7278-82.

        117. Sriram, D., Devakaram, R.V., Dinakaran, M., Yogeeswari, P., Aromatic Amino Analogues of Artemisinin: Synthesis and In-vivo Antimalarial Activity, Med. Chem. Res. 2010 19:524-32.

        116. Kumar, R.S., Mahesh, S.M., Perumal, S., Banerjee, D., Yogeeswari, P., Sriram, D., A facile synthesis and discovery of highly functionalized tetrahydropyridines and pyridines as antimycobacterial agents, Chem. Pharm. Bull. 2010 58:602-10.

        115. Sriram, D., Yogeeswari, P., Vyas, D.R.K., Senthilkumar, P., Bhat, P., Srividya, M., 5-Nitro-2-furoic acid hydrazones: Design, synthesis and in-vitro antimycobacterial evaluation against log and starved phase cultures, Bioorg Med Chem Lett. 2010 20: 4313-6.

        114. Manikannan, R., Muthusubramanian, S., Yogeeswari, P., Sriram D. Selective one-pot multicomponent synthesis and antitubercular evaluation of 5-(aryl/cyclohexylsulphanyl)-2-alkoxy-4,6-diarylnictinonitriles, Bioorg Med Chem Lett. 2010 Jun 1;20(11):3352-5.

        113. Yogeeswari P, Ragavendran J.V., Sriram D., Priyanka A., Ganguly S., Sunil Kumar Reddy A., Arvind Semwal. Effectiveness of antiepileptic GABA analogues for the treatment of neuropathic pain, Pharmacol. Online 2010 1: 575-590.

        112. Debjani Banerjee, Yogeeswari P, Pritesh Bhat, Anisha Thomas, Sriram D. Synthesis, In-vitro evaluation and computational studies of novel isatinyl derivcatives for their activity against HIV-TB co-infection, Int. J. Drug Des. Discov. 2010 Jan; 1(1): 65-80.

        111. Kumar RS, Rajesh SM, Perumal S, Banerjee D, Yogeeswari P, Sriram D. Novel three-component domino reactions of ketones, isatin and amino acids: synthesis and discovery of antimycobacterial activity of highly functionalised novel dispiropyrrolidines., Eur J Med Chem. 2010 Jan;45(1):411-22.  

        110. Kumar RS, Perumal S, Shetty KA, Yogeeswari P, Sriram D. 1,3-Dipolar cycloaddition of C-aryl-N-phenylnitrones to (R)-1-(1-phenylethyl)-3-[(E)-arylmethylidene]tetrahydro-4(1H)-pyridinones: synthesis and antimycobacterial evaluation of enantiomerically pure spiroisoxazolidines, Eur J Med Chem. 2010 Jan;45(1):124-33.

        109. Karthikeyan SV, Bala BD, Raja VP, Perumal S, Yogeeswari P, Sriram D., A highly atom economic, chemo-, regio- and stereoselective synthesis and evaluation of spiro-pyrrolothiazoles as antitubercular agents, Bioorg Med Chem Lett. 2010 Jan 1;20(1):350-3.

        108. Sriram D, Yogeeswari P, Dinakaran M, Banerjee D, Bhat P, Gadhwal S., Discovery of novel antitubercular 2,10-dihydro-4aH-chromeno[3,2-c]pyridin-3-yl derivatives, Eur J Med Chem. 2010 Jan;45(1):120-3.

        107. Balamurugan K, Jeyachandran V, Perumal S, Manjashetty TH, Yogeeswari P, Sriram D., A microwave-assisted, facile, regioselective Friedländer synthesis and antitubercular evaluation of 2,9-diaryl-2,3-dihydrothieno-[3,2-b]quinolines, Eur J Med Chem. 2010 Feb;45(2):682-8.

        106. Sriram D, Yogeeswari P, Senthilkumar P, Sangaraju D, Nelli R, Banerjee D, Bhat P, Manjashetty TH., Synthesis and Antimycobacterial Evaluation of Novel Phthalazin-4-ylacetamides Against log- and Starved Phase Cultures, Chem Biol Drug Des. 2010 Apr; 75(4) 381-91.

        105. Arvind Semwal, Yogeeswari P, Ragavendran, J.V., Sriram D, James Stables, Discovery of isatinimino derivatives as new leads for neuropathic pain treatment: An isomeric modification approach, Int. J. Drug Des. Discov. 2010 Apr 1(2): 169-187.

        104. Sriram D, Yogeeswari P, Senthilkumar P, Sangaraju D, 5-Nitrothiazolylthiosemicarbazones: synthesis and antimycobacterial evaluation against tubercular and non-tubercular mycobacterial species, J Enzyme Inhibition Med Chem. 2010 Feb;25(1):105-10.

2009

103.         Yogeeswari P, Semwal A, Mishra R, Sriram D., Current approaches with the glutamatergic system as targets in the treatment of neuropathic pain, Expert Opin Ther Targets. 2009 Aug;13(8):925-43.

102.         Sriram D, Yogeeswari P, Senthilkumar P, Dewakar S, Rohit N, Debjani B, Bhat P, Veugopal B, Pavan VV, Thimmappa HM., Novel pthalazinyl derivatives: synthesis, antimycobacterial activities, and inhibition of Mycobacterium tuberculosis isocitrate lyase enzyme, Med Chem. 2009 Sep;5(5):422-33.

101.         Ranjith Kumar R, Perumal S, Senthilkumar P, Yogeeswari P, Sriram D., A facile synthesis and antimycobacterial evaluation of novel spiro-pyrido-pyrrolizines and pyrrolidines, Eur J Med Chem. 2009 Sep;44(9):3821-9.

100.         M. Shalini, P. Yogeeswari, D. Sriram, J.P. Stables, Cyclization of the semicarbazone template of aryl semicarbazones: synthesis and anticonvulsant activity of 4,5-diphenyl-2H-1,2,4-triazol-3(4H)-one, Biomed. Pharmacother., 63, 187-193, 2009.

99.         P. Senthilkumar, J. Long, R. Swetha, V. Shruthi, R.R. Wang, S. Preethi, P. Yogeeswari, Y.T. Zheng, D. Sriram, Synthesis of zidovudine derivatives with anti-HIV-1 and antibacterial activities, Nucleosides Nucleotides Nucleic Acids 28:89-102, 2009.

98.         P. Senthilkumar, M. Dinakaran, Y. Chandraseakaran, P. Yogeeswari, D. Sriram D, Synthesis and in-vitro antimycobacterial evaluation of 1-(cyclopropyl/2,4-difluorophenyl/tert-butyl)-1,4-dihydro-8-methyl-6-nitro-4-oxo-7-substituted secondary amino) quinoline-3-carboxylic acids, Arch Pharm (Weinheim) 342:100-12, 2009.

97.         P. Senthilkumar, M. Dinakaran, P. Yogeeswari, A. China, V. Nagaraja, Antimycobacterial activities of novel fluoroquinolones, Biomed. Pharmacother. 63, 27-35, 2009.

96.         D. Sriram, P. Yogeeswari, P. Dhakla, P. Senthilkumar, D. Banerjee, T.H. Manjashetty, 5-Nitrofuran-2-yl derivatives: synthesis and inhibitory activities against growing and dormant mycobacterium species, Bioorg Med Chem Lett. 19:1152-4, 2009.

95.         D. Sriram, D. Banerjee, P. Yogeeswari, Efavirenz Mannich bases: synthesis, anti-HIV and antitubercular activities, J Enzyme Inhib Med Chem. 24:1-5, 2009.

94.     P. Senthilkumar, M. Dinakaran, P. Yogeeswari, D. Sriram, A. China, V. Nagaraja, Synthesis and antimycobacterial activities of novel 6-nitroquinolone-3-carboxylic acids, Eur J Med Chem. 44:345-58, 2009.

93.     D. Sriram, P. Yogeeswari, Y. Priya, Antimycobacterial activity of novel N-(substituted)-2-isonicotinoylhydrazinocarbothioamide endowed with high activity towards isoniazid resistant tuberculosis, Biomed. Pharmacother. 63, 36-39, 2009.

92.     M. Dinakaran, P. Senthilkumar, P. Yogeeswari, D. Sriram, Antitubercular activities of novel benzothiazolo naphthyridone carboxylic acid derivatives endowed with high activity toward multi-drug resistant tuberculosis, Biomed. Pharmacother. 63, 11-18, 2009.

91.     Ranjith Kumar R, Perumal S, Manju SC, Bhatt P, Yogeeswari P, Sriram D., An atom economic synthesis and antitubercular evaluation of novel spiro-cyclohexanones, Bioorg Med Chem Lett. 2009 Jul 1;19(13):3461-5.

90.     Karthikeyan SV, Perumal S, Shetty KA, Yogeeswari P, Sriram D., A microwave-assisted facile regioselective Fischer indole synthesis and antitubercular evaluation of novel 2-aryl-3,4-dihydro-2H-thieno[3,2-b]indoles. Bioorg Med Chem Lett. 2009 Jun 1;19(11):3006-9.

 

2008

89.     P. Yogeeswari, J.V. Ragavendran, D. Sriram, R. Kavya, K. Vanitha, H. Neelakantan. Newer N-phthaloyl GABA derivatives with antiallodynic and antihyperalgesic activities in both sciatic nerve and spinal nerve ligation models of neuropathic pain. Pharmacology, 81, 21-31, 2008.

88.     J.V. Ragavendran, D. Sriram, S. Kotapati, J. Stables, P. Yogeeswari. Newer GABA derivatives for the treatment of epilepsy including febrile seizures: A bioisosteric approach. Eur. J. Med. Chem., 43, 2650-5, 2008.

87.     R.R. Kumar, S. Perumal, P. Senthilkumar, P. Yogeeswari, D. Sriram. Discovery of antimycobacterial spiro-piperidin-4-ones: an atom economic, stereoselective synthesis, and biological intervention. J. Med. Chem. 51, 5731-5735, 2008.

86.     M. Dinakaran, P. Senthilkumar, P. Yogeeswari, A. China, V. Nagaraja, D. Sriram. Synthesis, antimycobacterial activities and phototoxic evaluation of 5H-thiazolo[3,2-a]quinoline-4-carboxylic acid derivatives. Med. Chem. 4, 482-491, 2008.

85.     M. Dinakaran, P. Senthilkumar, P. Yogeeswari, A. China, V. Nagaraja, D. Sriram. Novel ofloxacin derivatives: synthesis, antimycobacterial and toxicological evaluation. Bioorg. Med. Chem. Lett., 18, 1229-1236, 2008.

84.     D. Sriram, P. Yogeeswari, M. Dinakaran, M. Sowmya. Synthesis, anti-HIV and antitubercular activities of nelfinavir diester derivatives. Biomed. Pharmacother., 62, 1-5, 2008.

83.     P. Senthilkumar, M. Dinakaran, D. Banerjee, R.V. Devakaram, P. Yogeeswari, A. China, V. Nagaraja, D. Sriram. Synthesis and antimycobacterial evaluation of newer 1-cyclopropyl-1,4-dihydro-6-fluoro-7-(substituted secondary amino)-8-methoxy-5-(sub)-4-oxoquinoline-3-carboxylic acids. Bioorg. Med. Chem., 16, 2558-2569, 2008.

82.     M. Dinakaran, P. Senthilkumar, P. Yogeeswari, A. China, V. Nagaraja, D. Sriram. Antimycobacterial activities of novel 2-(sub)-3-fluoro/nitro-5,12-dihydro-5-oxobenzothiazolo[3,2-a]quinoline-6-carboxylic acid. Bioorg Med Chem., 16, 3408-3418, 2008.

81.     M. Dinakaran, P. Senthilkumar, P. Yogeeswari, A. China, V. Nagaraja, D. Sriram. Antimycobacterial and phototoxic evaluation of novel 6-fluoro/nitro-4-oxo-7-(sub)-4H-[1,3]thiazeto[3,2-a]quinoline-3-carboxylic acid. Int. J. Antimicrob. Agents., 31, 337-344, 2008.

80.     L. Sebastian, A. Desai, M.N. Shampur, P. Yogeeswari, D. Sriram, Vasanthapuram R. N-Methylisatin-beta-thiosemicarbazone derivative (SCH 16) is an inhibitor of Japanese encephalitis virus infection in vitro and in vivo. Virol. J., 5:64, 2008.

 

 2007

79.  P. Yogeeswari, J. Vaigunda Ragavendran, D. Sriram, Y. Nageswari, R. Kavya, N. Sreevatsan, K. Vanitha, J. Stables. Discovery of 4-Aminobutyric acid derivatives possessing anticonvulsant and antinociceptive activities: A Hybrid pharmacophore approach. J. Med. Chem., 50, 2459-2467, 2007.

78.  J.V. Ragavendran, I. Vikram Reddy, P. Yogeeswari, D. Sriram. Synthesis of 4-{[(3Z)-2-oxo-1,2-dihydro-3H-indol-3-ylidene]amino}-N-substituted phenyl) butanamides possessing antiallodynic and antihyperalgersic activities in two rat models of neuropathic pain. Med. Chem. Res., 15, 225-226, 2007.

77.  J. V. Ragavendran, D. Sriram, S.K. Patel, I. Vikram Reddy, N. Bharathwajan, J. Stables, P. Yogeeswari. Design and Synthesis of Anticonvulsants from a Combined Phthalimide-GABA –Anilide and Hydrazone Pharmacophore. Eur. J. Med. Chem., 42, 146-151, 2007.

76.  P. Yogeeswari, J.V. Ragavendran, D. Sriram. Neuropathic pain: Strategies in drug discovery and treatment. Expert Opinion on Drug Discovery, 2, 169-184, 2007.

75.  P. Yogeeswari, D. Sriram, P. Sahitya, J.V. Ragavendran, V. Ranganadh.Synthesis and anticonvulsant activity of 4-(2-(2,6-dimethylphenylamino)-2-oxoethylamino)-N-(substituted)butanamides: A Pharmacophoric hybrid approach. Bioorg. Med. Chem. Lett., 17, 3712-3715, 2007.

74.  A.S.K. Reddy, J.V. Ragavendran, P. Yogeeswari, D. Sriram. Pharmacological screening of candidate anticonvulsants in the animal model of febrile seizures. Med. Chem. Res., 15, 285-286, 2007.

73.  D. Sriram, P. Senthilkumar, M. Dinakaran, P. Yogeeswari, A. China, V. Nagaraja. Antimycobacterial activities of novel 1-(cyclopropyl/tert-butyl/4-fluorophenyl)-1,4-dihydro- 6-nitro-4-oxo-7-(substituted secondary amino)-1,8-naphthyridine-3-carboxylic acid. J. Med. Chem., 50, 6232-6239, 2007.

72.  S. Mehta, P. Yogeeswari, Roheeth Kumar, D. Sriram. Heteroaryl-substituted semicarbazones: Synthesis and anticonvulsant activity of N-(3-Methylpyridin-2-yl)-substituted semicarbazones. J. Het. Chem., 43, 1287-1293, 2007.

71.  D. Sriram, P. Yogeeswari, M. Dinakaran, R. Thirumurugan. Antimycobacterial activity of novel 1-(5-cyclobutyl-1,3-oxazol-2-yl)-3-(sub)phenyl/pyridylthiourea endowed with high activity toward multi-drug resistant tuberculosis. J. Antimicrob. Chemother. 59, 1194-1196, 2007.

70.  R.R. Kumar, S. Perumal, P. Senthilkumar,  P. Yogeeswari, D. Sriram. An atom efficient, solvent-free, green synthesis and antimycobacterial evaluation of 2-amino-6-methyl-4-aryl-8-[(E)-arylmethylidene]-5,6,7,8-tetrahydro-4H-pyrano[3,2-c]pyridine-3-carbonitriles. Bioorg. Med. Chem. Lett. 17, 6459-6462, 2007.

69.  P. Senthil Kumar, M. Dinakaran, P. Yogeeswari, D. Sriram. Synthesis and antitubercular activities of 1-(cyclopropyl/t-butyl/4-fluorophenyl)-1,4-dihydro-6-nitro-4-oxo-7-(substituted secondary amines)-1,8-naphthyridine-3-carboxylic acid. Med. Chem. Res., 15, 281-282, 2007.

68.  D. Sriram, P. Yogeeswari, Prathiba Dakhla, P. Senthil Kumar, Debjani Banerjee. N-Hydroxythiosemicarbazones: Synthesis and in-vitro antitubercular activity. Bioorg. Med. Chem. Lett., 17, 1888-1893, 2007.

67.  D. Banerjee, T.R. Bal, P. Yogeeswari, D. Sriram, L. Sebastin, A. Desai, S.N. Madhusudhana, V. Ravi. Isatin derivatives as inhibitor of Japanese encephalitis virus entry and replication in-vitro. Med. Chem. Res., 15, 133-135, 2007.

66.  Shalini, P. Yogeeswari, D. Sriram, S. Induja. Microwave-assisted Synthesis, Anticonvulsant activity and Quantum Mechanical modeling of N-(4-Bromo-3-methylphenyl)semicarbazones. J. Zhejiang Univ. Section B (Springer), 8, 45-55, 2007.

65.  K.N. Purna, P. Dhakla, P. Senthil Kumar, P. Yogeeswari, D. Sriram. 5-Nitro-2-furaldehyde thiosemicarbazones: Synthesis and in-vitro antimycobacterial activities. Med. Chem. Res., 15, 223-224, 2007.

64.  M. Dinakaran, C. Yogesh, P. Yogeeswari, D. Sriram  Synthesis of various 7-substituted-1-t-butyl-1,4-dihydro-8-methyl-6-nitro-4-oxo quiniline-3-carboxylic acid. Med. Chem. Res., 15, 328, 2007.

63.  D. Sriram, P. Yogeeswari, G. Senchani, D. Banerjee. Newer Tetracycline derivatives: Synthesis, anti-HIV, antimycobacterial activities and inhibition of HIV-1 integrase. Bioorg. Med. Chem. Lett.,17, 2372-2375, 2007.

62.  D. Sriram, P. Yogeeswari, N. Raveendra Babu, K.N. Purna. Synthesis and in-vitro anti-HIV activities of Didanosine prodrugs. J. Enzyme Inhib., 22, 51-55, 2007.

61.  M.A. Ali, M.S. Yar, A.A. Siddiqui, D. Sriram, P. Yogeeswari, E. De Clercq. Synthesis and anti-HIV activity of N'-nicotinoyl--3-(4'-hydroxy-3'-methylphenyl)-5-[substituted phenyl]-2-pyrazolines. Acta. Pol. Pharm., 64, 423-428, 2007.

60.  J.V. Ragavendran, P. Roheeth Kumar, P. Yogeeswari, Design of GABA uptake inhibitors: synthesis and anticonvulsant properties, Neurol. Asia, 12, 113-114, 2007.

 

2006

59.  D. Sriram, P. Yogeeswari, M.R. Kishore Synthesis and anti-HIV activity of nevirapine prodrugs. Pharmazie., 61, 895-897, 2006.

58.  M.S. Yar, M.A. Ali, D. Sriram, P. Yogeeswari. Synthesis and antimicrobial activity of 3-(4'-hydroxy-3'-methylphenyl)-5-[(substuted) phenyl]-4,5-dihydro-1H-1-pyrazolyl-4-pyridylmethanone derivatives. Acta. Pol. Pharm., 63, 491-496, 2006.

57.  M. Shalini, P. Yogeeswari, D. Sriram, P. Kudyar, P.R. Kumar, S. Induja, J.P. Stables Quantum mechanical modeling of N4-(2, 5-disubstituted phenyl) semicarbazones: synthesis and anticonvulsant activity of N4-(2, 5-dimethylphenyl/ -2-fluoro-5-methyl phenyl) semicarbazones. Med. Chem., 2, 617-625,  2006.

56.  D. Sriram, P. Yogeeswari, R. Thirumurugan, P. Roheeth Kumar. Discovery of Newer Antitubercular Oxazolyl thiosemicarbazones. J. Med. Chem. 49, 3448-3450, 2006.

55.  D. Sriram, P. Yogeeswari, K. Madhu. Synthesis and in-vitro antitubercular activity of some 1-[(4-sub)phenyl]- 3-(4-{1-   [(pyridine-4-carbonyl)hydrazono]ethyl phenyl) thiourea. Bioorg. Med. Chem. Lett. 16, 876-878, 2006.

54.  D. Sriram, P. Yogeeswari, R.V. Devakaram. Synthesis, in vitro and in vivo antimycobacterial activities of diclofenac acid hydrazones and amides. Bioorg. Med. Chem., 14, 3113-3118, 2006.

53.  D. Sriram, P. Yogeeswari, S.P. Reddy Synthesis of Pyrazinamide Mannich bases and its antitubercular properties. Bioorg. Med. Chem. Lett., 16, 2113-2116, 2006.

52.  D. Sriram, A. Aubry, P. Yogeeswari, L.M. Fischer. Gatifloxacin derivatives: Synthesis, antimycobacterial activities, and inhibition of Mycobacterium tuberculosis DNA gyrase. Bioorg. Med. Chem. Lett., 16, 2982-2985, 2006.

51.  D. Sriram, P. Yogeeswari, K. Meena. Design, synthesis, anti-HIV and antitubercular activities of isatin derivatives. Pharmazie, 61, 271-274, 2006.

50.  P. Yogeeswari, D. Sriram, J. Vaigunda Raghavendran, R. Thirumurugan, S. Induja, J.P. Stables. Synthesis and structure-activity relationship on anticonvulsant aryl semicarbazones. Med. Chem., 2, 55-62, 2006.

49.  P. Yogeeswari, D. Sriram, R. Thirumurugan, J.P. Stables 2,4-Dimethoxyphenyl semicarbazones with anticonvulsant activity against three animal models of seizure: Synthesis and Pharmacological evaluation Bioorg. Med. Chem., 14, 3106-3112, 2006.

48.  P. Yogeeswari, D. Sriram, R.Thirumurugan, T. R. Bal Epibatidine and its analogues as nicotinic acetylcholine receptor agonist. An update. Nat. Prod. Res., 20, 497-505, 2006.

47.  P. Yogeeswari, R.Thirumurugan, D. Sriram,  L.R.J. Suniljit, J. Vaigunda Ragavendran, R. Kavya, K. Rakhra, J.P. Stables. Synthesis of some new semicarbazone derivatives as anticonvulsants with GABA- mediated mechanism. Acta. Pharm., 56, 259-272, 2006.

46.  M. Shaharyar, A.A. Siddiqui, M. Asharaf Ali, D. Sriram, P. Yogeeswari. Synthesis and in-vitro antimycobacterial activity of N1-Nicotinoyl-3-(4’-hydroxy-3’-methyl phenyl)-5-[(sub)phenyl]-2-pyrazolines. Bioorg. Med. Chem. Lett., 16, 3947-3949, 2006.

45.  D. Sriram, P. Yogeeswari, N.S. Myneedu, V. Saraswat. Abacavir prodrugs: Microwave-assisted synthesis and their evaluation of anti-HIV activities. Bioorg. Med. Chem. Lett., 16, 2127-2129, 2006.

44.  D. Sriram, T. R. Bal, P. Yogeeswari, D.R. Radha, V. Nagaraja. Evaluation of antimycobacterial and DNA gyrase inhibition of fluoroquinolone derivatives. J. Gen. App. Microbiol., 52, 195-200, 2006.

43.  P. Yogeeswari, J.V. Ragavendran, D. Sriram. An Update on GABA Analogs for CNS Drug Discovery. Recent Patent on CNS Drug Discov.,  Vol 1 (First issue) 113-118, 2006.

2005

42.  P. Yogeeswari, D. Sriram, J.V. Raghavendran, R. Thirumurugan. The GABA shunt: An attractive and potential therapeutic target in the treatment of epileptic disorders. Curr. Drug Metabolism, 6, 127-140, 2005.

41.  P. Yogeeswari, D. Sriram, R. Thirumurugan, J.V. Raghavendran, K. Sudhan, Roheeth Kumar, J. Stables. Discovery of N-(2,6-Dimethylphenyl) substituted Semicarbazones as Anticonvulsants : Hybrid Pharmacophore-based design J. Med. Chem., 48, 6202-6211, 2005.

40.  D. Sriram, T. R. Bal, P. Yogeeswari. Aminopyrimidinimino isatin analogues: Design and synthesis of novel non- nucleoside HIV-1 reverse transcriptase inhibitors with broad-spectrum anti-microbial properties Med. Chem., 1, 277-285, 2005.

39.  D. Sriram, T. R. Bal, P. Yogeeswari. Newer aminopyrimidinimino isatin analogues as non-nucleoside HIV-1 reverse transcriptase inhibitors for HIV and other opportunistic infections of AIDS: Design, synthesis and biological evaluation. Farmaco, 60, 377-384, 2005.

38.  D. Sriram, P.Yogeeswari, A.N. Nagappa. Combinatorial Synthesis of anti-HIV-1 agents. Comb. Chem. High Throughput Screen., 8(6), 377-385, 2005.

37.  D. Sriram, P. Yogeeswari, R.Thirumurugan, T. R. Bal. Camptothecin and its analogues: A review on their chemotherapeutic potential. Nat. Prod. Res., 19, 393-412, 2005.

36.  P.Yogeeswari, D. Sriram, V.Veena, R.Kavya, K.Rakhra, S.Mehta, J.VaigundaRagavendran, R.Thirumurugan, J.P.Stables. Synthesis of Novel Aryl semicarbazones as Potential Anticonvulsant Agents. Biomed. Pharmacother., 59, 51-55, 2005.

35.  P. Yogeeswari, D. Sriram, S. Mehta, D. Nigam, M. Mohan Kumar, S. Murugesan, J.P. Stables. Anticonvulsant and neurotoxicity evaluation of some 6-substituted benzothiazolyl-2-thiosemicarbazones. Farmaco, 60 (1), 1-5, 2005.

34.  P. Yogeeswari and D. Sriram Betulinic acid and its derivatives: A review on their biological properties. Curr. Med. Chem., 12 (3), 763-771, 2005.

33.  D. Sriram, P. Yogeeswari, J.S. Basha, D. R. Radha, V. Nagaraja. Synthesis and Antimycobacterial evaluation of various 7- Substituted Ciprofloxacin Derivatives Bioorg. Med. Chem., 13, 5774-5778, 2005.

32.  D. Sriram, P. Yogeewari and K. Madhu. Synthesis and in-vitro antimycobacterial activity of some isonicotinyl hydrazones. Bioorg. Med. Chem. Lett., 15, 4502-4505, 2005.

31.  T.R. Bal, B. Anand, P. Yogeeswari, D. Sriram. Synthesis and evaluation of anti-HIV activity of isatin b-thiosemicarbazone derivatives. Bioorg. Med. Chem. Lett., 15, 4451-4455, 2005.

30.  D. Sriram, P. Yogeeswari, T.G. Ashok Kumar Microwave-assisted synthesis, and anti-YFV activity of 2, 3-diaryl-1, 3-thiazolidin-4-ones J. Pharm. Pharm. Sci., 8, 429-466, 2005.

29.  D. Sriram, P. Yogeeswari, N. Srichakravarthy, T. R. Bal. Synthesis of zidovudine prodrugs with broad-spectrum chemotherapeutic properties for the effective treatment of HIV/AIDS. Biomed. Pharmacother. 59, 452-455, 2005.

28.  D. Sriram, P. Yogeeswari, N. Srichakravarthy, T. R. Bal. Nevirapine derivatives with broad spectrum chemotherapeutic properties for the effective treatment of HIV / AIDS. Biomed. Pharmacother., 59, 456-459, 2005.

27.  D. Sriram, P. Yogeeswari, T.G. Ashok Kumar. Microwave-assisted synthesis, anti-HIV activity of 2, 3-diaryl-1, 3-thiazolidin-4-ones. Ind. J. Pharm. Sci., 67, 496-499, 2005.

26.  D. Sriram, P. Yogeeswari, T.G. Ashok Kumar. Microwave Assisted Synthesis, Anti-HIV, and Anti-YFV Activities of Schiff Bases of N-Hydroxy-N1-Aminoguanidine tosylate. Ind. J. Pharm. Sci., 67, 493-496, 2005.

25.  D. Sriram, T. R. Bal, P. Yogeeswari. Aminopyrimidinimino isatin analogues: Design of novel non- nucleoside HIV-1 reverse transcriptase inhibitors with broad-spectrum chemotherapeutic properties. J. Pharm. Pharm. Sci., 8, 565-577, 2005.

24.  P. Yogeeswari, D. Sriram, R. Kavya, S. Tiwari. Synthesis and in-vitro cytotoxicity evaluation of gatifloxacin Mannich bases. Biomed. Pharmacother.,  59, 501-510, 2005.

23.  D. Sriram, P. Yogeeswari, Gayatri Gopal. Synthesis, anti-HIV and antitubercular activities of lamivudine prodrugs. Eur. J. Med. Chem., 40, 1373-1376, 2005.

22.  D. Sriram, T. R. Bal, P. Yogeeswari. Design, synthesis and biological evaluation of novel non- nucleoside HIV-1 reverse transcriptase inhibitors with broad-spectrum antimicrobial properties: Aminopyrimidinimino isatin analogues. Med. Chem. Res., 14, 211-228, 2005.

 

2003-2004

21.     D. Sriram, V. S. Rao, K. V. G. Chandrasekhar and P. Yogeeswari. Progress in the research of artemisinin and its analogues as anti-malarials: an update Nat. Prod. Res., 18(6), 503-527, 2004.

20.     D. Sriram, T. R. Bal, P. Yogeeswari. Design, synthesis and biological evaluation of novel non- nucleoside HIV-1 reverse transcriptase inhibitors with broad-spectrum chemotherapeutic properties. Bioorg. Med. Chem., 12, 5865-5873, 2004.

19.     P. Yogeeswari, J. Vaigunda Raghavendran, R. Thirumurugan, A. Saxena. D. Sriram. Ion channels as important targets for antiepileptic drug design. Curr. Drug Targets, 5, 589-602, 2004.

18.     D. Sriram, P. Yogeeswari, R. Thirumurugan. Antituberculous activity of some aryl semicarbazones derivatives. Bioorg. Med. Chem. Lett., 15, 3923-3924, 2004.

17.     P. Yogeeswari, D. Sriram, S.N. Pandeya, J.P. Stables. 4-Sulphamoylphenyl semicarbazones with anticonvulsant activity. Farmaco, 59, 609-613, 2004.

16.     P. Yogeeswari, R. Thirumurugan, R. Kavya, J. Selwyn Samuel, J.P. Stables, D. Sriram. 2-Methyl, 3-chlorophenyl-substituted semicarbazones: Synthesis and anticonvulsant activity. Eur. J. Med. Chem., 39, 729-734, 2004.

15.     D. Sriram, K. Jyothi Mallika and P. Yogeeswari. Synthesis of Tetrahydro-2H-[1, 3, 5] thiadiazine-5-(4-pyridylcarboxamido)-2-thione with antitubercular activity. Sci. Pharm., 75, 35-41, 2004.

14.     D. Sriram, P. Yogeeeswari, N. Srichakravarthy, Tanushree Ratan Bal. Synthesis of Stavudine Amino acid Ester Prodrugs with Broad-Spectrum Chemotherapeutic Properties for the Effective Treatment of HIV/AIDS. Bioorg. Med. Chem. Lett., 14, 1085-1087, 2004.

13.     P. Yogeeswari, D. Sriram, A.Brahmandam, I.Sridharan, R.Thirumurugan and J.P. Stables. Synthesis of novel aryl semicarbazones as anticonvulsants with GABA-mediated mechanism. Med. Chem. Res., 12(2), 57-68, 2003.

12.     P. Yogeeswari, D. Sriram, V.Saraswat, J.Vaigunda Ragavendran, M.Mohan Kumar, S.Murugesan, R.Thirumurugan, J.P.Stables. Synthesis and Anticonvulsant and Neurotoxicity Evaluation of N4 –Phthalimido Phenyl (Thio) Semicarbazides. Eur. J. Pharm. Sci., 20, 341-346, 2003.

11.     D. Sriram, P. Yogeeswari. Towards the Design and Development of Agents with Broad Spectrum Chemotherapeutic Properties for the Effective Treatment of HIV / AIDS. Curr. Med. Chem., 10, 1909-1915, 2003.

 

2001-2002

10. S.N. Pandeya, P. Yogeeswari, D. Sriram, G.Nath. Antibacterial and antifungal activities of N-Mannich bases of 3-[N2-pyrimethaminylimino] isatin. Ind. J. Pharm. Sci., 64, 209-212, 2002.

9. D. Sriram, P. Yogeeswari, S.N.Pandeya, S. Ananthan. Antituberculous activity of isatin derivatives. Sci. Pharm., 70, 73-79, 2002.

8. P. Yogeeswari, D. Sriram, L.R.J. Suniljit, S.S.Kumar, J.P.Stables. Anticonvulsant and neurotoxicity evaluation of some 6-chlorobenzothiazolyl-2-thiosemicarbazones. Eur. J. Med. Chem., 37, 231-236, 2002.

7. S.N. Pandeya, P. Yogeeswari, E.A.Sausville, A.B.Mauger, V.L.Narayanan, Synthesis and antitumour evaluation of 4-bromophenyl semicarbazones, Arzneim. Forschung/ Drug Res., 52, 103-108, 2002.

6. S.N. Pandeya, D. Sriram, P.Yogeeswari, S. Ananthan. Antituberculous activity of Norfloxacin Mannich bases with Isatin derivatives. Chemotherapy, 47, 266-269, 2001.

5. S.N.Pandeya, D. Sriram, P. Yogeeswari, J.P. Stables. Anticonvulsant and Neurotoxicity evaluation of 5-(un)-substituted isatinimino derivatives. Pharmazie, 56, 875-878, 2001.

 

1998-2000

4. S.N.Pandeya, P. Yogeeswari, E.A.Sausville, A.B.Mauger, V.L.Narayanan, Synthesis and antitumour activity of some aryl semicarbazones, Sci. Pharm. 68, 369-377, 2000.

3. S.N.Pandeya, P. Yogeeswari, J.P. Stables, Synthesis and anticonvulsant activity of 4-bromophenyl substituted aryl semicarbazones, Eur. J. Med. Chem., 35, 879-886, 2000.

2. S.N. Pandeya, P. Yogeeswari, D. Sriram, E. De Clercq, C. Pannecouque, M. Witvrouw. Synthesis and Screening for Anti-HIV activity of some N-Mannich bases of isatin derivatives. Chemotherapy, 45, 192-196, 1999.

1. S.N. Pandeya, P. Yogeeswari, D. Sriram, G.Nath. Synthesis and antimicrobial activity of N-Mannich bases of 3-[N’-sulphadoximino] Isatin and its methyl derivative. Boll. Chim. Farm. 137(8), 321-324, 1998.




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