Our lab is principally engaged in new chemistry and methods towards functionalized material surfaces/ interfaces. The research in our lab is highly multidisciplinary and aims to resolve fundamental challenges in material surfaces by exploiting Photo & Macromolecules as tools. The achievements have emerged as new research directions in the field of Biointerface that are summarized as follows: 

1. Chemoselective C-H Bond Phototransformation on Organic Surfaces


Based on the use of the newly developed confined photocatalytic reactions, chemoselective photo-transformation of surface C-H bonds on organic polymer substrates have been demonstrated, and showed strong power to dictate the assembly of functional organic, inorganic and biological building-blocks at functionalized organic surfaces/interfaces.


2. New Protein Phase Transition Materials and Applications


Engineered surface modification is of prime importance in modern material science. The use of bio-inspired catecholamine and recently reported coordination complexes of natural polyphenols and Fe(III) ions are excellent approaches towards this purpose, however, they still suffer from some problematic issues such as the easy formation of colored surface due to undesirable side oxidations on phenols and metal doping as well as difficulty to construct the stimuli-responsive reversible transition on surface state. In our lab, we endeavour to manipulate a surface property towards ultra-performance, multi-functionalities and smartness/responsiveness by utilizing newly-discovered lysozyme phase transition. The phase-transited lysozyme product consisting of amyloid-contained microfiber network could stably attach onto metals, oxides, semiconductors and polymers. Such priming process imparts moderate hydrophilicity, enhanced corrosion resistance to surfaces and less colors. The priming also affords mild positive charges and enriched C-H bonds on surfaces, which consequently supports the growth of a series of functional building blocks including polymer brushes, colloids, vesicles, small molecules and bio-macromolecules based on chemically specific interactions. 


3. DNA-Mediated Micro/Nano-Lithography on Nobel Metals


In Nature, certain organisms can perform microbial corrosion on base metals by oxidation of neutral metallic atoms. Our lab describe the first discovery of biological nucleic acids able to catalyze and mediate gold oxidation from neutral Au0 to trivalent Au(III) under certain oxidative environments provided by mild oxidizing reagent N-bromosuccinimide or amino acids. A new biolithography technique for gold patterning is further developed. The investigation on the mechanism revealed that the coordination between nitrogen atoms in A, C, G, T nucleobases and trivalent Au(III) played a key catalytic role during this process.


4. Lipid Giant Unilamellar Vesicles: Fundamental Research and Applications 


High quality lipid giant unilamellar vesicles (GUVs) are an ideal model as an artificial cell to study properties and structural function of biomembrane as well as construct bio-inspired cellular factory. Currently the major limitations to perplex the revolutionary development of this field are (1) the high polydisperisty of prepared GUVs; (2) poor stability from highly fragile GUVs; (3) limited functionality on GUVs; (4) big difficulty to manipulate GUVs to form higher grade self-assembling structures. The research in our lab is thereby aiming to resolving these challenges through better understanding and control on the mechanism of GUVs electroformation and  probing the new interplay model between GUVs and surfaces. 


Spotlights on News in Our Lab

1. Welcome new members Chunlin Yue, Yuan Ha and Jin Gu to join in our group! 

2. Dr. Weihong Zhang successfully   received the grant for his               outstanding postdoctoral research from Ministry of Education of China.
Congrats to Dr. Zhang!.

3. Zhengfang Wu has reported her newest result in Chemistry A European Journal on the field of chemoselective C-H bond phototransformation on organic surfaces. Congrats to Wu!

4. Zhengfang Wu has reported her newest result in Industrial & Engineering Chemistry Research  on the field of chemoselective C-H bond phototransformation on organic surfaces. Congrats to Wu! 

5. Xiaoyan Mu has reported her newest result in Langmuir on the field of chemoselective C-H bond phototransformation on organic surfaces. Congrats to Mu!

6. Our lab has launched a new review article in ACS Applied Materials & Interfaces on the field of chemoselective C-H bond phototransformation on organic surfaces. Congrats to all of us!

7.  Our lab has launched a new review article in Chemical Reviews on the field of chemoselective C-H bond phototransformation on organic surfaces. Congrats to all of us!

8. The website for our lab is founded by Dr. Peng Yang on 09/16/2014.