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Publications

12.  Spencer, M.K.,* Radzinski, N.P.,* Tripathi, S., Chowdhury, S., Herrin, R.P., Chandran, N.N., Daniel, A.K., and West, J.D. (2013) Pronounced Toxicity Differences between Homobifunctional Protein Cross-Linkers and Analogous Monofunctional Electrophiles.  Chem. Res. Toxicol. 26, 1720-1729.        *equal contribution 

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11.  Naticchia, M.R., Brown, H.A., Garcia, F.J., Lamade, A.M., Justice, S.L., Herrin, R.P., Morano, K.A., and West, J.D. (2013) Bifunctional Electrophiles Cross-Link Thioredoxins with Redox Relay Partners in Cells.  Chem. Res. Toxicol. 26, 490-497.

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10.  West, J.D., Wang, Y., and Morano, K.A. (2012) Small Molecule Activators of the Heat Shock Response:  Chemical Properties, Molecular Targets, and Therapeutic Promise.  Chem. Res. Toxicol. 25, 2036-2053.  (featured review)

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9.  Wang, Y., Gibney, P.A., West, J.D., and Morano, K.A. (2012) The yeast Hsp70 Ssa1 is a sensor for heat shock response activation by thiol-reactive compounds.  Mol. Biol. Cell 23, 3290-3298.  (highlighted article)

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8.  West, J.D., Stamm, C.E., Brown, H.A., Justice, S.L., and Morano, K.A. (2011) Enhanced Toxicity of the Protein Cross-Linkers Divinyl Sulfone and Diethyl Acetylenedicarboxylate in Comparison to Related Monofunctional Electrophiles.  Chem. Res. Toxicol. 24, 1457-1459.

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7.  West, J.D. , Stamm, C.E., and Kingsley, P.J. (2011) Structure-Activity Comparison of the Cytotoxic Properties of Diethylmaleate and Related Molecules:  Identification of Diethyl Acetylenedicarboxylate as a Thiol Cross-Linking Agent.  Chem. Res. Toxicol24, 81-88.

publisher's site


6.  Trott, A.*, West, J.D.*, Klaić, L., Westerheide, S.D., Silverman, R.B., Morimoto, R.I., and Morano, K.A. (2008) Activation of Heat Shock and Antioxidant Responses by the Natural Product Celastrol: Transcriptional Signatures of a Thiol-Targeted Molecule.  Mol. Biol. Cell, 19, 1104-1112.           *equal contribution 

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5.  West, J.D. and Marnett, L.J. (2006) Reactive Intermediates as Modulators of Cell Signaling and Cell Death. Chem. Res. Toxicol. 19, 173-194. (featured review)

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4.  West, J.D. and Marnett, L.J. (2005) Alterations in Global Gene Expression Induced by the Lipid Peroxidation Product, 4-Hydroxy-2-nonenal. Chem. Res. Toxicol. 18, 1642-1653. 

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3.  West, J.D., Ji, C., and Marnett, L.J. (2005) Modulation of DNA Fragmentation Factor 40 Nuclease Activity by Poly(ADP-Ribose) Polymerase-1. J. Biol. Chem. 280, 15141-15147. 

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2.  West, J.D., Ji, C., Amarnath, V., Schneider, C., Duncan, S., Rizzo, C.J., Brash, A.R., and Marnett, L.J. (2004) Induction of Apoptosis in Colorectal Carcinoma Cells Treated with 4-Hydroxy-2-nonenal and Related Compounds. Chem. Res. Toxicol. 17, 453-462. 

publisher's site


1.  Marnett, L.J., Riggins, J.N., and West, J.D. (2003) Endogenous Generation of Reactive Oxidants and Electrophiles and Their Reactions with DNA and Protein. J. Clin. Invest. 111, 583-593.  (invited review)

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