Welcome to the Weihl Lab
Our goal is to understand the molecular mechanisms of protein inclusion formation, disaggregation and clearance in myodegenerative (skeletal muscle) and neurodegenerative diseases. We believe that dysfunction in protein quality control (molecular chaperones) and protein degradation pathways (e.g. the ubiquitin proteasome system, autophagy and endocytosis) disrupt cellular protein homeostasis resulting in degenerative phenotypes and normal aging. We employ complementary experimental techniques such as biochemistry, cell culture, animal models, and patient tissue to achieve these goals.