W. Clayton Thompson, Ph.D.


  • Paper: how (lack of) statistical power misleads in preclinical trials of obesity pharmacotherapies Freshly printed in IJO: A quantitative analysis of statistical power identifies obesity end points for improved in vivo preclinical study design.  We focus on obesity, but the idea will be quite familiar to anyone who works in drug discovery.  An experiment finds (in mice, say) that modulation of a target has a statistically significant effect on an endpoint of interest.  So the search begins for the mechanism of action, and thus other endpoints are examined.  The problem (in addition to issues with multiple testing) is that the endpoints are not independent.  They are linked via some (poorly understood, typically nonlinear) interactions, and the data are very noisy. These two features (nonlinearity and noisiness) combine so that different endpoints have different ...
    Posted May 5, 2017, 11:19 AM by Clay Thompson
  • 2017 Atlantic Causal Inference Conference I will be in the audience at the 2017 Atlantic Causal Inference Conference hosted by the UNC Causal Inference Research Group. A near-return to my alma mater.
    Posted Apr 26, 2017, 7:42 AM by Clay Thompson
  • Relocation I am now in the Research Triangle Park area of North Carolina.  You can find me at SAS working as a research statistician and developer.
    Posted Jul 16, 2016, 7:56 AM by Clay Thompson
Showing posts 1 - 3 of 6. View more »

Basic Information

William Clayton Thompson ('Clay')

Research Statistician Developer
Multivariable Models R&D
SAS Institute
Cary, NC, USA

Research Interests

Mathematical/computational modeling of physiological processes
Model calibration and validation for large-scale systems models
Modular coding, algorithm design, and data structures for large-scale models
Computational tools for reproducible research
Uncertainty quantification, variability modeling, rigorous model comparison
Mathematical and statistical aspects of inverse problems; statistical inference
Practical applications of functional analysis and measure theory
Scientific and mathematical methods to improve public policy

Recent Publications

See all Publications.

W. Clayton Thompson, Yingjiang Zhou, Saswata Talukdar, and C.J. Musante, PF-05231023, a long-acting FGF21 analogue, decreases body weight by reduction of food intake in non-human primates, JPKPD 43 (2016) 411-425. PMID 27405817

J. Selimkhanov, W.Clayton Thompson, T.S. Maurer, and C.J. Musante, Evaluation of a mathematical model of rat body weight regulation in application to caloric restriction and drug treatment studies, PLoS ONE 11 (2016) e0155674.

Recent Presentations

See all Presentations.