Announcements

Paper: how (lack of) statistical power misleads in preclinical trials of obesity pharmacotherapies
Freshly printed in IJO: A quantitative analysis of statistical power identifies obesity end points for improved in vivo preclinical study design. We focus on obesity, but the idea will be quite familiar to anyone who works in drug discovery. An experiment finds (in mice, say) that modulation of a target has a statistically significant effect on an endpoint of interest. So the search begins for the mechanism of action, and thus other endpoints are examined. The problem (in addition to issues with multiple testing) is that the endpoints are not independent. They are linked via some (poorly understood, typically nonlinear) interactions, and the data are very noisy. These two features (nonlinearity and noisiness) combine so that different endpoints have different ...
Posted May 5, 2017, 11:19 AM by Clay Thompson

2017 Atlantic Causal Inference Conference
I will be in the audience at the 2017 Atlantic Causal Inference Conference hosted by the UNC Causal Inference Research Group. A nearreturn to my alma mater.
Posted Apr 26, 2017, 7:42 AM by Clay Thompson

Relocation
I am now in the Research Triangle Park area of North Carolina. You can find me at SAS working as a research statistician and developer.
Posted Jul 16, 2016, 7:56 AM by Clay Thompson
Basic InformationWilliam Clayton Thompson ('Clay')
Research Statistician Developer Multivariable Models R&D SAS Institute Cary, NC, USA
Research InterestsMathematical/computational modeling of physiological processes Model calibration and validation for largescale systems models Modular coding, algorithm design, and data structures for largescale models Computational tools for reproducible research Uncertainty quantification, variability modeling, rigorous model comparison Mathematical and statistical aspects of inverse problems; statistical inference Practical applications of functional analysis and measure theory Scientific and mathematical methods to improve public policy
Recent Publications
W. Clayton Thompson, Yingjiang Zhou, Saswata Talukdar, and C.J. Musante, PF05231023, a longacting FGF21 analogue, decreases body weight by reduction of food intake in nonhuman primates, JPKPD 43 (2016) 411425. PMID 27405817
J. Selimkhanov, W.Clayton Thompson, T.S. Maurer, and C.J. Musante, Evaluation of a mathematical model of rat body weight regulation in application to caloric restriction and drug treatment studies, PLoS ONE 11 (2016) e0155674.
Recent Presentations 