This quirky drama/comedy from 1993 starred Mary Stuart Masterson, Aidan Quinn, and Johnny Depp and featured Spokane, Washington prominently.
Alternate Hospital Shot 2
The train seen in the opening scenes of the film is the Pend Orielle Railroad, which operates out of Ione, WA (north of Spokane). This scenic train provides trips to Spokane, Idaho, and British Columbia.
The house where Benny (Aidan Quinn) & Joon (Mary Stuart Masterson) live is at 301 North Cedar Street (the corner of Cedar & Water) in Peaceful Valley, Spokane.
The auto shop where Benny & Eric (Oliver Platt) work at in the film is Hilliard Tire at 5404 North Market Street in Spokane.
The road corner where Sam (Johnny Depp) sits and waits for Joon is right across from Joon's house on the corner of West Water Avenue & North Cedar Street. It's hardly recognizable because of the huge house there now, but the rock wall in the background makes a good landmark.
Ruthie (Julianne Moore) lives in apartment at 1303 West 10th Avenue in Spokane (thanks to Michael W.).
The scene where Sam puts on a clown act involving his hat was in Riverfront Park in Spokane. The specific spot is on the hill in front of the rides, across the river from the carousel on the north side.
The park bench where Benny has a seat after Sam's routine is in Riverfront Park just across from the Carousel.
In one quick scene, Benny visits Eric at his house at 2101 East Springfield Avenue in Spokane, with the giant grain silos in the background.
Mary Lou's Milk Bottle at 802 West Garland Avenue in Spokane, right next door to Ferguson's Cafe at 804 West Garland, where the interiors were filmed.
Main Street under the Maple Street bridge. This is right next to the house from Vision Quest.
The hospital at the end of the film is now The Academy at 1216 Superior Street (thanks to Julie).
Poker game house
Alternate Hospital Shot 3
(see attachment below)