A fundamental mystery of brain science is to understand how networks of neurons assemble during development and function in circuits to enable perception and behavior. Unraveling this mystery requires an understanding of the relationships between the cellular-level properties of circuits – the anatomical “wiring diagram” of connectivity on the one hand, and the functional properties of single neurons and synapses on the other – and the systems-level properties such as sensory responses or motor outputs.
In the Neural Circuits Lab, we are applying a new generation of optical and optogenetic tools to observe both fine-scale circuit features and systems-level responses at the same time, in the living brain. We combine these optical approaches with advanced physiological and anatomical techniques to address previously inaccessible questions about neural circuitry and its development in mammalian visual cortex.
News: New paper "Emerging feed-forward inhibition allows the robust formation of direction selectivity in the developing ferret visual cortex" has been accepted for publication in Journal of Neurophysiology (see Publications).
Hiring: The Paradis lab and Van Hooser lab are looking to hire a joint postdoc (NIH training-grant eligible, generally US citizens and permanent residents).
Funding: We have been supported by American Recovery and Reinvestment Act (ARRA) funds (article), the John Merck Foundation, the Charles H. Hood Foundation, the National Science Foundation of the US and the National Institutes of Health of the US.