Trevor T-J Chong

'The problem of neurology is to understand man himself' - Wilder Penfield

Brief Biography

I am a neurologist and cognitive neuroscientist based at the Monash Institute of Cognitive and Clinical Neurosciences in Melbourne, Australia. I am currently appointed as a Senior Research Fellow and Australian Research Council DECRA Fellow at Monash, and consult at St Vincent's Hospital and Alfred Health. 

I completed both my undergraduate research training (BMedSc) and medical training (MB,BS) with Honours at Monash University in 2002. I then embarked on doctoral research with Jason Mattingley at the University of Melbourne, and in collaboration with Nancy Kanwisher at MIT. After being awarded my PhD in 2007, I returned to speciality training in Neurology, and was admitted to Fellowship of the Royal Australasian College of Physicians (FRACP) as a consultant neurologist in 2013. That year, I was awarded an NH&MRC Neil Hamilton Fairley Early Career Fellowship, which I took to Oxford to work with Masud Husain. I returned to Australia in 2015 to the ARC Centre of Excellence for Cognition and its Disorders in Sydney, before commencing my current position at Monash University.

Research Interests

I lead the Cognitive Neurology Laboratory at Monash University. 

Our group studies the neurobiology of learning, memory and decision-making in health and disease. 

We address fundamental questions in cognitive neuroscience, such as:

  • How do humans make decisions?
  • What motivates individuals to engage in effortful behaviour?
  • What are the mechanisms that lead to impaired decision-making and motivation in patients with dopaminergic dysfunction, such as Parkinson's disease?
  • How can such impairments better diagnosed and managed in the clinic?
Our research bridges the domains of basic cognitive neuroscience and clinical cognitive neurology, with the ultimate goal of developing new paradigms that may be translated into the clinical setting to guide the diagnosis and management of cognitive symptoms.

To accomplish this, we combine insights from psychology, economics and neuroscience, and apply cross-disciplinary methodologies, including:
  • Classical behavioural psychophysics
  • Computational modelling
  • Electroencephalography
  • Structural brain imaging (high resolution MRI, diffusion tensor imaging) 
  • Functional brain imaging (functional MRI, resting state fMRI)
  • Pharmacological interventions
  • Lesion/Patient studies

Visit our website for current job openings and student opportunities.


Qualifications

  • Fellow, The Royal Australasian College of Physicians
  • Doctor of Philosophy, Melbourne
  • Bachelor of Medicine, Bachelor of Surgery (Honours), Monash
  • Bachelor of Medical Science (Honours), Monash

 

Selected Fellowships and Awards

  • 2018-2020: Discovery Early Career Research Fellow (Australian Research Council, Australia)
  • 2014: Postdoctoral Fellows Award (Cognitive Neuroscience Society, USA)
  • 2013-2016: Neil Hamilton Fairley Early Career Fellowship (NH&MRC, Australia)
  • 2008: Dean's Award for Excellence in a PhD thesis (University of Melbourne)
  • 2007: Melbourne Abroad Travelling Scholarship (University of Melbourne)
  • 2006: Travelling Award for Research Training (NH&MRC, Australia)
  • 2006: Dartmouth College Summer Research Fellowship (Dartmouth College, New Hampshire, USA)
  • 2006: Postgraduate Overseas Research Experience Scholarship (University of Melbourne)
  • 2006: Australian Neuroscience Society Student Travel Award (Australian Neuroscience Society)
  • 2005-2007: Medical Postgraduate Award (NH&MRC, Australia)
  • 2004: Australian Postgraduate Award (Commonwealth of Australia)


Selected Publications

Book Chapters

  • Chong, T.T-J., & D'Souza, W. (2013). Epilepsy in the elderly. In: S Shorvon, R Guerrini, M Cook, S Lhatoo (Eds.). Oxford Textbook of Epilepsy and Epileptic Seizures (pp. 201-210). Oxford, UK: Oxford University Press. ISBN 978-0-199659-04-3
  • Chong, T.T-J., & Cook, M.J. (2013). Neuroimaging in the investigation of epilepsy. In: S Shorvon, R Guerrini, M Cook, S Lhatoo (Eds.). Oxford Textbook of Epilepsy and Epileptic Seizures (pp. 109-126). Oxford, UK: Oxford University Press. ISBN 978-0-199659-04-3
  • Chong, T.T-J., & Mattingley, J.B. (2008). Automatic and controlled processing within the mirror neuron system. In J. Pineda (Ed.). Mirror Neuron Systems: The Role of Mirroring Processes in Social Cognition (pp. 213-233)Totowa, NJ: Humana Press. ISBN 978-1-934115-34-3
 

Peer-Reviewed Journal Articles

  • Chong, T.T.-J. (2018). Updating the role of dopamine in human motivation and apathy. Current Opinion in Behavioral Sciences, 22, 35-41. [pdf]
  • Dawson, A., Dissanayaka, N.N., Evans, A., Frazzitta, G., Ferrazzoli, D., Ortelli, P., Verdejo-Garcia, A., Chong, T.T.-J., Yücel, M., & Carter, A. (2018). Neurocognitive correlates of addictive behaviours in Parkinson’s disease: A systematic review. European Neuropsychopharmacology, 28(5), 561-578.
  • Verdejo-Garcia, A., Chong, T.T.-J., Stout, J.C., Yücel, M., & London, E.D. (2018). Stages of dysfunctional decision-making in addiction. Pharmacology, Biochemistry and Behaviour, 164, 99-105. [pdf]
  • Chong, T.T.-J. (2017). Voodoo surgery? The distinct challenges of functional neuroimaging in clinical neurology. Brain, awx283, doi:10.1093/brain/awx283. [pdf]
  • Chong, T.T.-J., Bonnelle, V., Veromann, K.-R., Juurmaa, J., Taba, P., Plant, O., & Husain, M. (2017). Dissociation of reward and effort sensitivity in methcathinone-induced parkinsonism. Journal of Neuropsychology[pdf]
  • Miller, T.D., Chong, T.T-J., Aimola Davies, A.M., Ng, T.W.C., Johnson, M.R., Irani, S.R., Vincent, A., Husain, M. Jacob, S., Maddison, P., Kennard, C., Gowland, P.A., & Rosenthal, C.R. (2017) Focal CA3 hippocampal subfield atrophy following LGI1 VGKC-complex antibody limbic encephalitis. Brain, 14095), 1212-1219. [pdf]
  • Chong, T.T-J., Apps, M., Giehl, K., Sillence, A., Grima, L.L., & Husain, M. (2017). Neurocomputational mechanisms underlying subjective valuation of effort costs. PLoS Biology, 15(2), e1002598. [pdf]
  • Chong, T.T-J., & Husain, M. (2016). The role of dopamine in the pathophysiology and treatment of apathy. Progress in Brain Research, 229, 389-426. [pdf]
  • Chong, T.T-J., Bonnelle, V., & Husain, M. (2016). Quantifying motivation with effort-based decision-making paradigms in health and disease. Progress in Brain Research, 229, 71-100. [pdf]
  • Muhammed, K., Manohar, S., Ben Yehuda, M., Chong, T.T-J., Tofaris, G., Lennox, G., Bogdanovic, M., Hu, M., & Husain, M. (2016). Reward sensitivity deficits modulated by dopamine are associated with apathy in Parkinson's disease. Brain, 139(10), 2706-2721. [pdf]
  • Chong, T.T-J. (2015). Disrupting the perception of effort with continuous theta burst stimulation. Journal of Neuroscience, 35(39), 13269-13271. [pdf]
  • Manohar, S.G., Chong, T.T-J., Apps, M.A.J., Batla, A., Stamelou, M., Jarman, P.R., Bhatia, K.P., & Husain, M. (2015). Reward pays the cost of noise reduction in motor and cognitive control. Current Biology, 25(13), 1707-1716. [pdf]
  • Chong, T.T-J., Bonnelle, V., Manohar, S., Veromann, K-R., Muhammed, K., Tofaris, G.K., Hu, M., & Husain, M. (2015). Dopamine enhances willingness to exert effort for reward in Parkinson's disease. Cortex, 69, 40-46. [pdf]
  • Chong, T.T-J., Husain, M., & Rosenthal, C.R. (2014). Recognizing the unconscious. Current Biology, 24(21), R1033-1035. [pdf]
  • Chong, T.T-J., & Fedi, M. (2013). Acute management of stroke: Part II. Haemorrhagic stroke. Anaesthesia and Intensive Care Medicine, 14(9), 366-370. [pdf]
  • Chong, T.T-J., & Fedi, M. (2013). Acute management of stroke: Part I. Ischaemic stroke. Anaesthesia and Intensive Care Medicine, 14(9), 363-365. [pdf]
  • Chong, T.T-J., Cunnington, R., Williams, M.A., & Mattingley, J.B. (2009). The role of selective attention in matching observed and executed actions. Neuropsychologia, 47(3), 786-795[pdf]
  • Chong, T.T-J., Cunnington, R., Williams, M.A., Kanwisher, N., & Mattingley, J.B. (2008). fMRI adaptation reveals mirror neurons in human inferior parietal cortex. Current Biology, 18(20), 1576-1580[pdf]
    - Reviewed in: Current Biology, 18(20), R956-R959. [pdf]
    - Reviewed in: Nature Reviews Neuroscience, 9, 888-889. [pdf]
  • Chong, T.T-J., Williams, M.A., Cunnington, R., & Mattingley, J.B. (2008). Selective attention modulates inferior frontal gyrus activity during action observation. NeuroImage, 40(1), 298-307.  [pdf]
  • Kashima, Y., Gurumurthy, A.K., Chong, T., & Mattingley, J. (2007). Agency, Sociality, and Time. Psychological Inquiry, 18(2), 129-137. [pdf]
  • Kashima, Y., Gurumurthy, A.K., Ouschan, L., Chong, T., & Mattingley, J. (2007). Connectionism and self: James, Mead, and the stream of enculturated consciousness. Psychological Inquiry, 18(2), 73-96. [pdf]
  • Chong, T. (2001). Awareness: More than meets the eye. Psyche - An Interdisciplinary Journal of Research on Consciousness, 7(01). [pdf]