Highlights@Bionanomaterials Lab

생체적합성 나노소재 연구실에서 대학원생 및 학부인턴을 모집하고 있습니다.

 본 연구실의 연구 분야는 다음과 같습니다.

생체적합성 나노소재 기반 질병진단/치료 시스템 개발
- 저자극/무독성 나노소재 기반 기능성 화장품 개발
- 친환경 나노소재 기반 환경촉매 개발

미래 산업 전반과 밀접한 연관이 있는 나노소재 연구의 특성상, 졸업 후 의료, 화장품, 전자, 전기화학 관련 기업을 비롯, 연구소, 대학 등 연구기관에 이르기까지 다양한 진로 선택의 기회가 주어집니다.

관심 있는 학생은 화공생명공학부 권우성 교수(wkwon@sookmyung.ac.kr)에게 연락 바랍니다.

Photoluminescent and Biodegradable Porous Silicon Nanoparticles for Biomedical Imaging

Porous silicon nanoparticles (PSiNPs) have attracted increasing interest as biomedical probes for drug delivery and imaging. In particular, a set of unique properties including biodegradability, intrinsic photoluminescence, and favorable mesoporous structure providing high drug loading allow PSiNPs to address current challenges of translational nanomedicine. In this review, the important features of PSiNPs considered as a biomedical imaging probe will be concisely discussed along with recent advances in fabrication and theranostic applications. This work has been published as a cover article in Journal of Materials Chemistry B (IF = 5.047).

Controlled Growth of Fluorescent Silica Nanoparticles Using Two-phase Orthogonal Solvents for Bioimaging

최근 생체적합성 원소인 실리콘 기반의 실리카나노입자가 큰 주목을 받는 가운데,  비혼화성(immiscible) 용매를 이용해 실리카 나노입자의 물성을 조절할 수 있는 합성법을 개발했다. 실리카 나노입자의 화학적/양자적 구조 설계를 통해 발광성을 부여하고, 이를 통해 세포영상을 성공적으로 구현했다. 해당 결과는 Journal of Luminescence (IF = 2.732)에 게재되었으며, 특히 학부생(장희민, 16)이 연구를 주도하여 큰 주목을 받았다 . (관련기사)

(주)나노솔루션 기술이전 협약 체결 "발광/발열성 탄소양자점 저온 합성 및 표면개질 기술"

숙명여대 산학협력단은 지난 15일 탄소소재 개발, 생산 전문기업인 (주)나노솔루션과 기술이전 협약식을 열고, 화공생명공학부 권우성 교수가 개발한 "발광/발열성 탄소양자점 저온 합성 및 표면개질 기술" 노하우 이전 계약을 체결했다고 밝혔다. (관련기사)

Defect-Induced Fluorescence of Silica Nanoparticles for Bioimaging Applications

With biocompatibility, biodegradability, and high functionality, silica nanoparticles (SNPs) have been widely investigated for various biomedical applications. However, the lack of optical fluorescence has limited the application of SNPs as a degradable imaging agent. Here, we hydrothermally synthesized fluorescent SNPs by artificially generating optically active defect centers using tetraethyl orthosilicate and (3-aminopropyl)trimethoxysilane. The synthesized SNPs demonstrated strong blue photoluminescence originating from the dioxasilyrane and silylene defect centers with the aid of aminopropyl groups. Furthermore, phosphorescence was observed at 459 nm, indicating the presence of silylene in SNPs. Finally, these SNPs have been successfully utilized as a fluorescent probe for bioimaging of normal, cancer, and macrophage cells. This work has been published in ACS Applied Materials & Interfaces (IF = 8.456). 

Highly Luminescent Organic Nanorods from Air Oxidation of Para-substituted Anilines for Freestanding Deep-red Color Filers

Oxidation of aniline provides useful organic nanostructures with a wide variety of particle morphologies and properties. Accordingly, in the present study, novel luminescent organic nanorods (ONs) are synthesized through one-step air oxidation of para-substituted anilines without any shape-guiding surfactants. It is revealed that the phenazine-like structures in the ONs are largely responsible for their bright, photostable, deep-red luminescence with absolute quantum efficiency up to 46%. The potential application of ONs as a freestanding color filter for deep-red-light-emitting devices that could be used for color pixels of future displays is demonstrated. This work has been published in
Advanced Optical Materials (IF = 7.125).

In vivo Photoacoustic Imaging of Livers Using Hyaluronic Acid-Conjugated Silica Nanoparticles (Inside Cover)

Diagnosing the liver disease through imaging study is an important role of the Radiology department. Currently, ultrasound, CT and MRI are the most widely used imaging devices to diagnose liver diseases. The newly available photoacoustic imaging device, which provides high resolution anatomical and functional information in deep tissue non-invasively, is an attractive candidate to diagnose early stages of liver disease. However, the liver has insufficient photoacoustic contrast due to low optical absorbance in the near-infrared windows thus generating suboptimal liver images. In this study, we have developed a new hyaluronic acid silica nanoparticle (HA-SiNP) conjugates for liver-specific delivery to enhance the liver diagnosis. Our results indicate that HA-SiNP conjugates can be a promising liver targeted photoacoustic imaging contrast agent and liver targeted drug delivery agent. This work has been published as a cover article in Advanced Functional Materials (IF = 15.621).