The investigation of cancer therapy or tissue/organ engineering is crucial for human life. How can a mechanical engineer participate in this research direction? Up to date, it remains highly challenging because tissue or tumor are synergistically formed by vast number of interactive components that heavily interconnected via cell-cell and/or cell-environmental communications. The lack of effective tools therefore pose unprecedented hurdles in the research progression. Recently, the development of microtechnology have showed the environmental control in the scale of cells. In the Laboratory for Tissue Microengineering, we leverage the merits of microtechnologies and modeling to intervene the single-cell or multicellular systems. We seek the development of new engineering platform which allows spatial modulations such as physical stimuli (stretching, torque or geometric interface) or diffusion gradient of chemicals (growth factor, cytokines) to control and understand the dynamics of different physiological response. With the aids of mathematics and microengineering, we can investigate the biological phenomena downward to the dynamics of cytoskeletal structure, cellular chirality, cell migration, and upward to tissue development and cancer metastasis. Overall, with interdisciplinary capacity, we aim at providing repertoire of engineering tools for insightful discovery and solution for the medical threats such as cancer and degenerative diseases.
City University of Hong Kong
Department of Mechanical and Biomedical Engineering
Kowloon Tong, Hong Kong
Updated on Oct. 4, 2012