Molecular Pharmaceutics

December 4th, 2017-Volume 14, Issue 12

Surface Modification of Polysaccharide-Based Nanoparticles with PEG and Dextran and the Effects on Immune Cell Binding and Stimulatory Characteristics

Denise Bamberger, Dominika Hobernik, Matthias Konhäuser, Matthias Bros, and Peter R. Wich

Effects of Surface Charge of Hyperbranched Polymers on Cytotoxicity, Dynamic Cellular Uptake and Localization, Hemotoxicity, and Pharmacokinetics in Mice

Liyu Chen, Joshua D. Simpson, Adrian V. Fuchs, Barbara E. Rolfe, and Kristofer J. Thurecht

Tumor Selective Silencing Using an RNAi-Conjugated Polymeric Nanopharmaceutical

Sonke Svenson, Roy I. Case, Roderick O. Cole, Jungyeon Hwang, Sujan R. Kabir, Douglas Lazarus, Patrick Lim Soo, Pei-Sze Ng, Christian Peters, Pochi Shum, Beata Sweryda-Krawiec, Snehlata Tripathi, Derek van der Poll, and Scott Eliasof

Biocompatible ELR-Based Polyplexes Coated with MUC1 Specific Aptamers and Targeted for Breast Cancer Gene Therapy

Maria J. Piña, Alessandra Girotti, Mercedes Santos, J. Carlos Rodríguez-Cabello, and F. Javier Arias

Hydrogel-Forming Microneedle Arrays Made from Light-Responsive Materials for On-Demand Transdermal Drug Delivery

John G. Hardy, Eneko Larrañeta, Ryan F. Donnelly, Niamh McGoldrick, Katarzyna Migalska, Maelíosa T. C. McCrudden, Nicola J. Irwin, Louise Donnelly, and Colin P. McCoy

Therapeutic Antibody Engineering To Improve Viscosity and Phase Separation Guided by Crystal Structure

Chi-Kin Chow, Barrett W. Allan, Qing Chai, Shane Atwell, and Jirong Lu

Peptide- and Amine-Modified Glucan Particles for the Delivery of Therapeutic siRNA

Jessica L. Cohen, Yuefei Shen, Myriam Aouadi, Pranitha Vangala, Michaela Tencerova, Shinya U. Amano, Sarah M. Nicoloro, Joseph C. Yawe, and Michael P. Czech

Visualization and Quantitative Assessment of the Brain Distribution of Insulin through Nose-to-Brain Delivery Based on the Cell-Penetrating Peptide Noncovalent Strategy

Noriyasu Kamei, Tomotaka Shingaki, Yousuke Kanayama, Misa Tanaka, Riyo Zochi, Koki Hasegawa, Yasuyoshi Watanabe, and Mariko Takeda-Morishita

Charge Type, Charge Spacing, and Hydrophobicity of Arginine-Rich Cell-Penetrating Peptides Dictate Gene Transfection

Nabil A. Alhakamy, Prajnaparamita Dhar, and Cory J. Berkland

January 4, 2016-Volume 13, Issue 1

Limited Efficiency of Drug Delivery to Specific Intracellular Organelles Using Subcellularly “Targeted” Drug Delivery Systems

Amit Ranjan Maity and David Stepensky

Molecular Imaging of Pancreatic Cancer with Antibodies

Christopher G. England, Reinier Hernandez, Savo Bou Zein Eddine, and Weibo Cai

Efficient and Tumor Targeted siRNA Delivery by Polyethylenimine-graft-polycaprolactone-block-poly(ethylene glycol)-folate (PEI–PCL–PEG–Fol)

Li Liu, Mengyao Zheng, Damiano Librizzi, Thomas Renette, Olivia M. Merkel, and Thomas Kissel

Characteristics of Cell-Penetrating Peptide/Nucleic Acid Nanoparticles

Helerin Margus, Piret Arukuusk, Ülo Langel, and Margus Pooga

Selective Intracellular Delivery of Recombinant Arginine Deiminase (ADI) Using pH-Sensitive Cell Penetrating Peptides To Overcome ADI Resistance in Hypoxic Breast Cancer Cells

Tzyy-Harn Yeh, Yun-Ru Chen, Szu-Ying Chen, Wei-Chiang Shen, David K. Ann, Jennica L. Zaro, and Li-Jiuan Shen

December 7, 2015-Volume 12, Issue 12

Nanotechnology Approaches for the Delivery of Exogenous siRNA for HIV Therapy

Simeon K. Adesina and Emmanuel O. Akala

Nanogel-Conjugated Reverse Transcriptase Inhibitors and Their Combinations as Novel Antiviral Agents with Increased Efficacy against HIV-1 Infection

T. H. Senanayake, S. Gorantla, E. Makarov, Y. Lu, G. Warren, and S. V. Vinogradov

Chitosan Nanoparticles for Nuclear Targeting: The Effect of Nanoparticle Size and Nuclear Localization Sequence Density

Salma N. Tammam, Hassan ME. Azzazy, Hans G. Breitinger, and Alf Lamprecht

Validation of Mitochondrial Gene Delivery in Liver and Skeletal Muscle via Hydrodynamic Injection Using an Artificial Mitochondrial Reporter DNA Vector

Yukari Yasuzaki, Yuma Yamada, Takuya Ishikawa, and Hideyoshi Harashima

Structure–Activity Relationship of PEGylated Polylysine Peptides as Scavenger Receptor Inhibitors for Non-Viral Gene Delivery

Nicholas J. Baumhover, Jason T. Duskey, Sanjib Khargharia, Christopher W. White, Samuel T.Crowley, Rondine J. Allen, and Kevin G. Rice

Nanoparticle-Delivered Antisense MicroRNA-21 Enhances the Effects of Temozolomide on Glioblastoma Cells

Jeyarama S. Ananta, Ramasamy Paulmurugan, and Tarik F. Massoud

November 2, 2015-Volume 12, Issue 11

Combinatorial Approach of Antigen Delivery Using M Cell-Homing Peptide and Mucoadhesive Vehicle to Enhance the Efficacy of Oral Vaccine

Bijay Singh, Sushila Maharjan, Tao Jiang, Sang-Kee Kang, Yun-Jaie Choi, and Chong-Su Cho

Live Imaging of Cellular Internalization of Single Colloidal Particle by Combined Label-Free and Fluorescence Total Internal Reflection Microscopy

Gerard D. Byrne, Driton Vllasaliu, Franco H. Falcone, Michael G. Somekh, and Snjezana Stolnik

Solubility Challenges in High Concentration Monoclonal Antibody Formulations: Relationship with Amino Acid Sequence and Intermolecular Interactions

Mariya Pindrus, Steven J. Shire, Robert F. Kelley, Barthélemy Demeule, Rita Wong, Yiren Xu, andSandeep Yadav

Assessment of the Behavior of Mesenchymal Stem Cells Immobilized in Biomimetic Alginate Microcapsules

Ane Garate, Jesús Ciriza, Javier G. Casado, Rebeca Blazquez, José Luis Pedraz, Gorka Orive, andRosa Maria Hernandez

Effects of Doxorubicin Delivery Systems and Mild Hyperthermia on Tissue Penetration in 3D Cell Culture Models of Ovarian Cancer Residual Disease

Sina Eetezadi, Raquel De Souza, Mirugashini Vythilingam, Rodrigo Lessa Cataldi, and Christine Allen

Antibody–Drug Conjugates (ADCs) Derived from Interchain Cysteine Cross-Linking Demonstrate Improved Homogeneity and Other Pharmacological Properties over Conventional Heterogeneous ADCs

Christopher R. Behrens, Edward H. Ha, Lawrence L. Chinn, Simeon Bowers, Gary Probst, MaureenFitch-Bruhns, Jorge Monteon, Amanda Valdiosera, Abel Bermudez, Sindy Liao-Chan, Tiffany Wong,Jonathan Melnick, Jan-Willem Theunissen, Mark R. Flory, Derrick Houser, Kristy Venstrom, ZoiaLevashova, Paul Sauer, Thi-Sau Migone, Edward H. van der Horst, Randall L. Halcomb, and David Y.Jackson

3D Printing of Medicines: Engineering Novel Oral Devices with Unique Design and Drug Release Characteristics

Alvaro Goyanes, Jie Wang, Asma Buanz, Ramón Martínez-Pacheco, Richard Telford, Simon Gaisford, and Abdul W. Basit

Trafficking of Gold Nanoparticles Coated with the 8D3 Anti-Transferrin Receptor Antibody at the Mouse Blood–Brain Barrier

Itsaso Cabezón, Gemma Manich, Raquel Martín-Venegas, Antoni Camins, Carme Pelegrí, and JordiVilaplana

October 5, 2015-Volume 12, Issue 10

Reductively Responsive Hydrogel Nanoparticles with Uniform Size, Shape, and Tunable Composition for Systemic siRNA Delivery in Vivo

Da Ma, Shaomin Tian, Jeremy Baryza, J. Christopher Luft, and Joseph M. DeSimone

Exogenous DNA Loading into Extracellular Vesicles via Electroporation is Size-Dependent and Enables Limited Gene Delivery

Tek N. Lamichhane, Rahul S. Raiker, and Steven M. Jay

Protamine/DNA/Niosome Ternary Nonviral Vectors for Gene Delivery to the Retina: The Role of Protamine

G. Puras, G. Martínez-Navarrete, M. Mashal, J. Zárate, M. Agirre, E. Ojeda, S. Grijalvo, R. Eritja,A. Diaz-Tahoces, M. Avilés-Trigueros, E. Fernández, and J. L. Pedraz

Synthesis of Reactive Polymers for Acrolein Capture Using AGET ATRP

Laura T. Beringer, Shaohua Li, Gary Gilmore, John Lister, and Saadyah Averick

September 8, 2015-Volume 12, Issue 9

Taming Cell Penetrating Peptides: Never Too Old To Teach Old Dogs New Tricks

Qianyu Zhang, Huile Gao, and Qin He

Immunoliposomes for Targeted Delivery of an Antifibrotic Drug

Liane Schuster, Oliver Seifert, Stefanie Vollmer, Roland E. Kontermann, Burkhard Schlosshauer, and Hanna Hartmann

Ligand-Modified Human Serum Albumin Nanoparticles for Enhanced Gene Delivery

Jennifer Look, Nadine Wilhelm, Hagen von Briesen, Nadja Noske, Christine Günther, Klaus Langer, and Erwin Gorjup

Photolytic Cross-Linking to Probe Protein–Protein and Protein–Matrix Interactions in Lyophilized Powders

Lavanya K. Iyer, Balakrishnan S. Moorthy, and Elizabeth M. Topp

Dual Receptor-Targeted Theranostic Nanoparticles for Localized Delivery and Activation of Photodynamic Therapy Drug in Glioblastomas

Suraj Dixit, Kayla Miller, Yun Zhu, Emilie McKinnon, Thomas Novak, Malcolm E. Kenney, and Ann-Marie Broome

Light-Controlled Delivery of Monoclonal Antibodies for Targeted Photoinactivation of Ki-67

Sijia Wang, Gereon Hüttmann, Zhenxi Zhang, Alfred Vogel, Reginald Birngruber, ShifalikaTangutoori, Tayyaba Hasan, and Ramtin Rahmanzadeh

Diels–Alder Hydrogels for Controlled Antibody Release: Correlation between Mesh Size and Release Rate

Susanne Kirchhof, Michela Abrami, Viktoria Messmann, Nadine Hammer, Achim M. Goepferich,Mario Grassi, and Ferdinand P. Brandl

Development of a Trispecific Antibody Designed to Simultaneously and Efficiently Target Three Different Antigens on Tumor Cells

Nazzareno Dimasi, Ryan Fleming, Carl Hay, Rob Woods, Linda Xu, Herren Wu, and Changshou Gao

August 3, 2015-Volume 12, Issue 8

Enhancing Glioblastoma-Specific Penetration by Functionalization of Nanoparticles with an Iron-Mimic Peptide Targeting Transferrin/Transferrin Receptor Complex

Ting Kang, Mengyin Jiang, Di Jiang, Xingye Feng, Jianhui Yao, Qingxiang Song, Hongzhuan Chen, Xiaoling Gao, and Jun Chen

July 6, 2015-Volume 12, Issue 7

Evaluation of Histidylated Arginine-Grafted Bioreducible PolymerTo Enhance Transfection Efficiency for Use as a Gene Carrier

Joung-Pyo Nam, Kihoon Nam, Jae-Woon Nah, and Sung Wan Kim

“Smart”Nanoparticles Enhance the Cytoplasmic Delivery of Anti-RhoC Silencing RNA and Inhibit theMigration and Invasion of Aggressive Breast Cancer Cells

Neha Kaushal, Yasemin Yuksel Durmaz, LeWei Bao, Sofia D. Merajver, and Mohamed E. H. ElSayed

Investigating theInteraction Pattern and Structural Elements of a Drug–Polymer Complex at the Molecular Level

Haichen Nie, Huaping Mo, Mingtao Zhang, Yang Song, Ke Fang, Lynne S. Taylor, Tonglei Li, and Stephen R. Byrn

June 1, 2015-Volume 12, Issue 6

Antibody–Drug Conjugates (ADCs):Magic Bullets at Last!

John M. Lambert

Design of Coltuximab Ravtansine,a CD19-Targeting Antibody–Drug Conjugate (ADC) for the Treatment of B-CellMalignancies: Structure–Activity Relationships and Preclinical Evaluation

E. Erica Hong, Hans Erickson, Robert J. Lutz, Kathleen R. Whiteman, Gregory Jones, Yelena Kovtun, Veronique Blanc, and John M. Lambert

NoninternalizingTargeted Cytotoxics for Cancer Therapy

Giulio Casi and Dario Neri

siRNA Inhibition of Endocytic Pathways to Characterize the Cellular Uptake Mechanisms of Folate-Functionalized Glycol Chitosan Nanogels

Paula Pereira, Sílvia S. Pedrosa, Jennifer M. Wymant, Edward Sayers, Alexandra Correia, Manuel Vilanova, Arwyn T. Jones, and Francisco M. Gama

Antibody-Mediated Neutralization of Perfringolysin O for Intracellular Protein Delivery

Nicole J. Yang, David V. Liu, Demetra Sklaviadis, Dan Y. Gui, Matthew G. Vander Heiden, and K. Dane Wittrup

Enhanced Peptide Delivery into Cells by Using the Synergistic Effects of a Cell-Penetrating Peptide and a Chemical Drug to Alter Cell Permeability

Jie-Lan Ma, Hu Wang, Yan-Lin Wang, Yong-Huang Luo, and Chang-Bai Liu

May 4, 2015-Volume 12, Issue 5

Inhibition of Bcr-Abl in Human Leukemic Cells with a Coiled-Coil Protein Delivered by a Leukemia-Specific Cell-Penetrating Peptide

Benjamin J. Bruno and Carol S. Lim

Oligonucleotide Delivery with Cell Surface Binding and Cell Penetrating Peptide Amphiphile Nanospheres

Didem Mumcuoglu, Melis Sardan, Turgay Tekinay, Mustafa O. Guler, and Ayse B. Tekinay

Hydrophilicity/Hydrophobicity Reversable and Redox-Sensitive Nanogels for Anticancer Drug Delivery

Hao Yang, Qin Wang, Wei Chen, Yanbing Zhao, Tuying Yong, Lu Gan, Huibi Xu, and Xiangliang Yang

April 6, 2015-Volume 12, Issue 4

Effect of Anionic PEGylated Polypeptide on Gene Transfection Mediated by Glycolipid Conjugate Micelles

Han-Xi Yi, Jie Wu, Yong-Zhong Du, Ying-Wen Hu, Hong Yuan, Jian You, and Fu-Qiang Hu

Delivery of Lipid Micelles into Infarcted Myocardium Using a Lipid-Linked Matrix Metalloproteinase Targeting Peptide

Juliane Nguyen, Richard Sievers, J. P. Michael Motion, Saul Kivimäe, Qizhi Fang, and Randall J. Lee

March 2, 2015-Volume 12, Issue 3

Branched Amphiphilic Cationic Oligopeptides Form Peptiplexes with DNA: A Study of Their Biophysical Properties and Transfection Efficiency

L. Adriana Avila, Luana R. M. M. Aps, Pinakin Sukthankar, Nicoleta Ploscariu, Sushanth Gudlur, Ladislav Šimo, Robert Szoszkiewicz, Yoonseong Park, Stella Y. Lee, Takeo Iwamoto, Luis C. S. Ferreira, and John M. Tomich

Guanidinium-Rich, Glycerol-Derived Oligocarbonates: A New Class of Cell-Penetrating Molecular Transporters That Complex, Deliver, and Release

siRNA

Paul A. Wender, Melanie A. Huttner, Daryl Staveness, Jessica R. Vargas, and Adele F. Xu

February 2, 2015-Volume 12, Issue 2

Micelle-like Nanoparticles as Carriers for DNA and siRNA

Gemma Navarro, Jiayi Pan, and Vladimir P. Torchilin

Smart Polymeric Nanoparticles for Cancer Gene Delivery

Guimei Lin, Hong Zhang, and Leaf Huang

Codelivery of DNA and siRNA via Arginine-Rich PEI-Based Polyplexes

Shan Lu, Viola B. Morris, and Vinod Labhasetwar

Synthetic Biology for Therapeutic Applications

Zhanar Abil, Xiong Xiong, and Huimin Zhao

Targeted Intracellular Delivery of Proteins with Spatial and Temporal Control

Demosthenes P. Morales, Gary B. Braun, Alessia Pallaoro, Renwei Chen, Xiao Huang, Joseph A. Zasadzinski, and Norbert O. Reich

Screening Nylon-3 Polymers, a New Class of Cationic Amphiphiles, for siRNA Delivery

Venkatareddy Nadithe, Runhui Liu, Bryan A. Killinger, Sara Movassaghian, Na Hyung Kim, Anna B. Moszczynska, Kristyn S. Masters, Samuel H. Gellman, and Olivia M. Merkel

January 5, 2015-Volume 12, Issue 1

Design and Evaluation of Endosomolytic Biocompatible Peptides as Carriers for siRNA Delivery

Wen Xu, Ran Pan, Danyang Zhao, Dafeng Chu, Yan Wu, Rong Wang, Baoling Chen, Yong Ding, Parisa Sadatmousavi, Yongfang Yuan, and P. Chen

Synthesis of a Novel Cyclic Prodrug of S-Allyl-glutathione Able To Attenuate LPS-Induced ROS Production through the Inhibition of MAPK Pathways in U937 Cells

Antonia Patruno, Erika Fornasari, Antonio Di Stefano, Laura S. Cerasa, Lisa Marinelli, Leonardo Baldassarre, Piera Sozio, Hasan Turkez, Sara Franceschelli, Alessio Ferrone, Viviana Di Giacomo, Lorenza Speranza, Mario Felaco, and Ivana Cacciatore

Versatile Cellular Uptake Mediated by Catanionic Vesicles: Simultaneous Spontaneous Membrane Fusion and Endocytosis

Chloé Mauroy, Pauline Castagnos, Julie Orio, Marie-Claire Blache, Isabelle Rico-Lattes, Justin Teissié, Marie-Pierre Rols, and Muriel Blanzat

Chirality Switching within an Anionic Cell-Penetrating Peptide Inhibits Translocation without Affecting Preferential Entry

Tohru Yamada, Sara Signorelli, Salvatore Cannistraro, Craig W. Beattie, and Anna Rita Bizzarri

Targeted Decationized Polyplexes for siRNA Delivery

Luís Novo, Kaori M. Takeda, Tamara Petteta, George R. Dakwar, Joep B. van den Dikkenberg, Katrien Remaut, Kevin Braeckmans, Cornelus F. van Nostrum, Enrico Mastrobattista, and Wim E. Hennink

Cellular Uptake Mechanism of TCTP-PTD in Human Lung Carcinoma Cells

Hyo Young Kim, Sabin Kim, Hae Jun Pyun, Jeehye Maeng, and Kyunglim Lee

Divalent Folate Modification on PEG: An Effective Strategy for Improving the Cellular Uptake and Targetability of PEGylated Polyamidoamine–Polyethylenimine Copolymer

Duanwen Cao, Shouqin Tian, Huan Huang, Jianhai Chen, and Shirong Pan

Relating Toxicity to Transfection: Using Sphingosine To Maintain Prolonged Expression in Vitro

Jamie L. Betker and Thomas J. Anchordoquy