ACS Chemical Biology

ACS Chemical Biology

July 2020: Volume 15, Issue 7

Scientific Response to the Coronavirus Crisis in Spain: Collaboration and Multidisciplinarity

Oscar Millet, Aitziber L. Cortajarena, Xavier Salvatella, Laura L. Kiessling*, and Jesús Jiménez-Barbero*

Physicochemical Tools for Visualizing and Quantifying Cell-Generated Forces

Ashley K. Nguyen and Kristopher A. Kilian*

Release Factor Inhibiting Antimicrobial Peptides Improve Nonstandard Amino Acid Incorporation in Wild-type Bacterial Cells

Erkin Kuru, Rosa-Maria Määttälä, Karen Noguera, Devon A. Stork, Kamesh Narasimhan, Jonathan Rittichier, Daniel Wiegand, and George M. Church*

June 2020: Volume 15, Issue 6

When the Others Become Us: A Chemist’s Perspective of the COVID-19 Outbreak in Italy

Laura Kiessling, Christina MacLaughlin, and Sara Sattin*

Antibody–PROTAC Conjugates Enable HER2-Dependent Targeted Protein Degradation of BRD4

Marı́a Maneiro, Nafsika Forte, Maria M. Shchepinova, Cyrille S. Kounde, Vijay Chudasama, James Richard Baker, and Edward W. Tate*

Light-Driven Activation of RNA-Guided Nucleic Acid Cleavage

Shaoru Wang, Lai Wei, Jia-Qi Wang, Huimin Ji, Wei Xiong, Jian Liu, Ping Yin, Tian Tian*, and Xiang Zhou*

Aptamer-T Cell Targeted Therapy for Tumor Treatment Using Sugar Metabolism and Click Chemistry

Chuan-Gang Liu, Yong Wang, Peng Liu, Qi-Li Yao, Yuan-Yuan Zhou, Chao-Fan Li, Qiu Zhao, Guang-Hui Liu, and Xiao-Lian Zhang*

Cellular Uptake and Cytosolic Delivery of a Cyclic Cystine Knot Scaffold

Huawu Yin, Yen-Hua Huang, Kirsten Deprey, Nicholas D. Condon, Joshua A. Kritzer, David J. Craik, and Conan K. Wang*

May 2020: Volume 15, Issue 5

No relevant articles.

April 2020: Volume 15, Issue 4

Fighting the Coronavirus Outbreak

Laura KiesslingPeng ChenJie WangJie P. Li*

March 2020: Volume 15, Issue 3

C-Mannosyl Lysine for Solid Phase Assembly of Mannosylated Peptide Conjugate Cancer Vaccines

Tim P. HogervorstR. J. Eveline LiLaura MarinoSven C. M. BruijnsNico J. MeeuwenoordDmitri V. FilippovHerman S. OverkleeftGijsbert A. van der MarelSandra J. van VlietYvette van Kooyk*Jeroen D. C. Codée*

February 2020: Volume 15, Issue 2

No relevant articles.

January 2020: Volume 15, Issue 1

No relevant articles.

December 2019: Volume 14, Issue 12

Cytosolic Delivery of Macromolecules in Live Human Cells Using the Combined Endosomal Escape Activities of a Small Molecule and Cell Penetrating Peptides

Jason AllenKristina NajjarAlfredo Erazo-OliverasHelena M. Kondow-McConaghyDakota J. BrockKristin GrahamElizabeth C. HagerAndrea L. J. MarschallStefan DübelRudolph L. JulianoJean-Philippe Pellois*

November 2019: Volume 14, Issue 11

No relevant articles.

October 2019: Volume 14, Issue 10

No relevant articles.

September 2019: Volume 14, Issue 9

Cell Membrane Composition Drives Selectivity and Toxicity of Designed Cyclic Helix–Loop–Helix Peptides with Cell Penetrating and Tumor Suppressor Properties

Grégoire J.-B. PhilippeDiana GasparCaibin ShengYen-Hua HuangAurélie H. BenfieldNicholas D. CondonJoachim WeidmannNicole LawrenceAlexander LöwerMiguel A. R. B. CastanhoDavid J. CraikSónia Troeira Henriques*

August 2019: Volume 14, Issue 8

Secondary Forces in Protein Folding

Robert W. NewberryRonald T. Raines*

July 2019: Volume 14, Issue 7

No relevant articles.

June 2019: Volume 14, Issue 6

No relevant articles.

May 2019: Volume 14, Issue 5

Targeted Protein Degradation through Cytosolic Delivery of Monobody Binders Using Bacterial Toxins

Nadine Eliane SchmitKatyayanee NeopaneOliver Hantschel*

April 2019: Volume 14, Issue 4

Esterification Delivers a Functional Enzyme into a Human Cell

Valerie T. Ressler, Kalie A. Mix, and Ronald T. Raines

March 2019: Volume 14, Issue 3

SPR-Measured Dissociation Kinetics of PROTAC Ternary Complexes Influence Target Degradation Rate

Michael J. Roy, Sandra Winkler, Scott J. Hughes, Claire Whitworth, Michael Galant, William Farnaby, Klaus Rumpel, and Alessio Ciulli

A Phenotypic Screening Approach Using Human Treg Cells Identified Regulators of Forkhead Box p3 Expression

Mei Ding, Johan Brengdahl, Madelene Lindqvist, Ulf Gehrmann, Elke Ericson, Stefan von Berg, Lena Ripa, and Rajneesh Malhotra

Efficient Intracellular Delivery of CRISPR-Cas Ribonucleoproteins through Receptor Mediated Endocytosis

Romain Rouet, and Daniel Christ

February 2019: Volume 14, Issue 2

No relevant articles.

January 201: Volume 14, Issue 1

No relevant articles.

December 2018: Volume 13, Issue 12

Responsible Peer Review

Katrin Karbstein

Dendrimer Heparan Sulfate Glycomimetics: Potent Heparanase Inhibitors for Anticancer Therapy

Olga V. Zubkova, Yassir A. Ahmed, Scott E. Guimond, Sophia-Louise Noble, John Holmes Miller, Raymond Alexander Alfred Smith, Victor Nurcombe, Peter C. Tyler, Marina Weissmann, Israel Vlodavsky, and Jeremy E. Turnbull

November 2018: Volume 13, Issue 11

CXC-Mediated Cellular Uptake of Miniproteins: Forsaking “Arginine Magic”

Xiaoting Meng, Tao Li, Yibing Zhao, and Chuanliu Wu

October 2018: Volume 13, Issue 10

In Situ Drug Delivery to Breast Cancer-Associated Extracellular Matrix

Jodie M. Fleming, Susan T. Yeyeodu, Ashley McLaughlin, Darren Schuman, and Darlene K. Taylor

Targeted Delivery of Cyclotides via Conjugation to a Nanobody

Soohyun Kwon, Joao N. Duarte, Zeyang Li, Jingjing J. Ling, Olivier Cheneval, Thomas Durek, Christina I. Schroeder, David J. Craik, and Hidde L. Ploegh

September 2018: Volume 13, Issue 9

Genetic Code Expansion in Animals

Wes Brown, Jihe Liu, and Alexander Deiters

The Unique Cofactor Region of Zika Virus NS2B–NS3 Protease Facilitates Cleavage of Key Host Proteins

Maureen E. Hill, Anil Kumar, James A. Wells, Tom C. Hobman, Olivier Julien, and Jeanne A. Hardy

The Protein Microenvironment Governs the Suitability of Labeling Sites for Single-Molecule Spectroscopy of RNP Complexes

Andreas Schmidt, Nadide Altincekic, Henrik Gustmann, Josef Wachtveitl, and Martin Hengesbach

August 2018: Volume 13, Issue 8

Surface-Modified Macrophages Facilitate Tracking of Breast Cancer-Immune Interactions

Bishnu P. Joshi, Joseph Hardie, Michael A. Mingroni, and Michelle E. Farkas

July 2018: Volume 13, Issue 7

No relevant articles.

June 2018: Volume 13, Issue 6

No relevant articles.

May 2018: Volume 13, Issue 5

Multiple Mechanisms of Zinc-Mediated Inhibition for the Apoptotic Caspases-3, -6, -7, and -8

Scott J. Eron, Derek J. MacPherson, Kevin B. Dagbay, and Jeanne A. Hardy

April 2018: Volume 13, Issue 4

Antimicrobial Metallopeptides

Jessica L. Alexander, Zechariah Thompson, and J. A. Cowan

A Switchable Site-Specific Antibody Conjugate

Zhigang Lyu, Lei Kang, Zakey Yusuf Buuh, Dawei Jiang, Jeffrey C. McGuth, Juanjuan Du, Haley L. Wissler, Weibo Cai, and Rongsheng E. Wang

March 2018: Volume 13, Issue 3

A Cell-Permeable Stapled Peptide Inhibitor of the Estrogen Receptor/Coactivator Interaction

Thomas E. Speltz, Jeanne M. Danes, Joshua D. Stender, Jonna Frasor and Terry W. Moore

February 2018: Volume 13, Issue 2

Special Issue on the Chemical Biology of CRISPR

Alyson G. Weidmann and Amit Choudhary

Frontiers in CRISPR

Alyson G. Weidmann

Discovering the Genome-Wide Activity of CRISPR-Cas Nucleases

Shengdar Q. Tsai

Discovery of Oligonucleotide Signaling Mediated by CRISPR-Associated Polymerases Solves Two Puzzles but Leaves an Enigma

Eugene V. Koonin and Kira S. Makarova

The Future of Multiplexed Eukaryotic Genome Engineering

David B. Thompson, Soufiane Aboulhouda, Eriona Hysolli, Cory J. Smith, Stan Wang, Oscar Castanon, and George M. Church

Identifying Novel Enhancer Elements with CRISPR-Based Screens

Jason C. Klein, Wei Chen, Molly Gasperini, and Jay Shendure

Genome Editing: Insights from Chemical Biology to Support Safe and Transformative Therapeutic Applications

Renee D. Wegrzyn, Andrew H. Lee, Amy L. Jenkins, Colby D. Stoddard, and Anne E. Cheever

The Promise and Challenge of In Vivo Delivery for Genome Therapeutics

Ross C. Wilson and Luke A. Gilbert

Editing the Genome Without Double-Stranded DNA Breaks

Alexis C. Komor, Ahmed H. Badran, and David R. Liu

Modulating DNA Repair Pathways to Improve Precision Genome Engineering

Katherine S. Pawelczak, Navnath S. Gavande, Pamela S. VanderVere-Carozza, and John J. Turchi

Protein Inhibitors of CRISPR-Cas9

Joseph Bondy-Denomy

January 2018: Volume 13, Issue 1

No relevant articles.

December 2017: Volume 12, Issue 12

No relevant articles.

November 2017: Volume 12, Issue 11

Intracellular Protein Delivery System Using a Target-Specific Repebody and Translocation Domain of Bacterial Exotoxin

Hee-Yeon Kim, Jung Ae Kang, Jeong-Hyun Ryou, Gyeong Hee Lee, Dae Seong Choi, Dong Eun Lee, and Hak-Sung Kim

October 2017: Volume 12, Issue 10

Enhancing the Potency of Nalidixic Acid toward a Bacterial DNA Gyrase with Conjugated Peptides

Marya Ahmed and Shana O. Kelley

September 2017: Volume 12, Issue 9

Peptide–Membrane Interaction between Targeting and Lysis

Katharina Stutz, Alex T. Müller, Jan A. Hiss, Petra Schneider, Markus Blatter, Bernhard Pfeiffer, Gernot Posselt, Gil Kanfer, Benoît Kornmann, Paul Wrede, Karl-Heinz Altmann, Silja Wessler, and Gisbert Schneider

Redesigned Spider Peptide with Improved Antimicrobial and Anticancer Properties

Sónia Troeira Henriques, Nicole Lawrence, Stephanie Chaousis, Anjaneya S. Ravipati, Olivier Cheneval, Aurélie H. Benfield, Alysha G. Elliott, Angela Maria Kavanagh, Matthew A. Cooper, Lai Yue Chan, Yen-Hua Huang, and David J. Craik

August 2017: Volume 12, Issue 8

A Novel Family of Small Molecules that Enhance the Intracellular Delivery and Pharmacological Effectiveness of Antisense and Splice Switching Oligonucleotides

Ling Wang, Yamuna Ariyarathna, Xin Ming, Bing Yang, Lindsey I. James, Silvia M. Kreda, Melissa Porter, William Janzen, and Rudolph L. Juliano

July 2017: Volume 12, Issue 7

No relevant articles.

June 2017: Volume 12, Issue 6

CRISPR–Cas9 Mediated DNA Unwinding Detected Using Site-Directed Spin Labeling

Narin S. Tangprasertchai, Rosa Di Felice, Xiaojun Zhang, Ian M. Slaymaker, Carolina Vazquez Reyes, Wei Jiang, Remo Rohs, and Peter Z. Qin

Systematic Synthesis and Binding Study of HIV V3 Glycopeptides Reveal the Fine Epitopes of Several Broadly Neutralizing Antibodies

Jared Orwenyo, Hui Cai, John Giddens, Mohammed N. Amin, Christian Toonstra, and Lai-Xi Wang

Heavy Metals Induce Decline of Derivatives of 5-Methycytosine in Both DNA and RNA of Stem Cells

Jun Xiong, Xiaona Liu, Qing-Yun Cheng, Shan Xiao, Lai-Xin Xia, Bi-Feng Yuan, and Yu-Qi Feng

May 2017: Volume 12, Issue 5

No relevant articles.

April 2017: Volume 12, Issue 4

No relevant articles.

March 2017: Volume 12, Issue 3

No relevant articles.

February 2017: Volume 12, Issue 2

Heparin-Promoted Cellular Uptake of the Cell-Penetrating Glycosaminoglycan Binding Peptide, GBPECP, Depends on a Single Tryptophan

Li-Chun HungIngjye JiangChien-Jung ChenJia-Yin LuYi-Fen HsiehPing-Hsieh KuoYi-Lin HungLily Hui-Ching WangMargaret Dah-Tsyr Changand Shih-Che Sue

pp 398–406

January 2017: Volume 12, Issue 1

Targeting NF-κB p65 with a Helenalin Inspired Bis-electrophile

John C. WidenAaron M. KempemaPeter W. Villaltaand Daniel A. Harki

pp 102–113

December 2016: Volume 11, Issue 12

Host Cell Interactions Are a Significant Barrier to the Clinical Utility of Peptide Antibiotics

Charles G. StarrJing Heand William C. Wimley

pp 3391–3399

November 2016: Volume 11, Issue 11

No relevant articles.

October 2016: Volume 11, Issue 10

No relevant articles.

September 2016: Volume 11, Issue 9

No relevant articles.

August 2016: Volume 11, Issue 8

Protease-Resistant and Cell-Permeable Double-Stapled Peptides Targeting the Rab8a GTPase

Philipp M. Cromm, Jochen Spiegel, Philipp Küchler, Laura Dietrich, Julia Kriegesmann, Mathias Wendt, Roger S. Goody, Herbert Waldmann, and Tom N. Grossmann

pp 2375–2382

July 2016: Volume 11, Issue 7

No relevant articles.

June 2016: Volume 11, Issue 6

Altering the Specificity of the Antibody Response to HIV gp120 with a Glycoconjugate Antigen

Chang-Cheng Liu, Canjia Zhai, Xiu-Jing Zheng, and Xin-Shan Ye

pp 1702–1709

May 2016: Volume 11, Issue 5

Targeting Tumor Cells by Natural Anti-Carbohydrate Antibodies Using Rhamnose-Functionalized Liposomes

Xuexia Li, Xiongjian Rao, Li Cai, Xuling Liu, Huixia Wang, Weinan Wu, Chenggang Zhu, Min Chen, Peng G. Wang, and Wen Yi

pp 1205–1209

April 2016: Volume 11, Issue 4

No relevant articles.

March 2016: Volume 11, Issue 3

No relevant articles.

February 2016: Volume 11, Issue 2

No relevant articles.

January 2016: Volume 11, Issue 1

Single-Cell, Time-Resolved Antimicrobial Effects of a Highly Cationic, Random Nylon-3 Copolymer on Live Escherichia coli

Heejun Choi, Saswata Chakraborty, Runhui Liu, Samuel H. Gellman, and James C. Weisshaar

pp 113–120

June 2015: Volume 10, Issue 6

Chemical Biology of Nucleic Acids

Jan Barciszewski, Victor E. Marquez, Jean-Jacques Vasseur, and Wojciech T. Markiewicz

pp 1358–1361

May 2015: Volume 10, Issue 5

No relevant articles

April 2015: Volume 10, Issue 4

Modulation of Alternative Splicing with Chemical Compounds in New Therapeutics for Human Diseases

Kenji Ohe and Masatoshi Hagiwara

pp 914–924

Computational Design and Experimental Characterization of Peptides Intended for pH-Dependent Membrane Insertion and Pore Formation

Yao Zhang, René Bartz, Gevorg Grigoryan, Michael Bryant, Jeff Aaronson, Stephen Beck, Nathalie Innocent, Lee Klein, William Procopio, Tom Tucker, Vasant Jadhav, David M. Tellers, and William F. DeGrado

pp 1082–1093

March 2015: Volume 10, Issue 3

No relevant articles.

February 2015: Volume 10, Issue 2

Polymer-Based Synthetic Dendritic Cells for Tailoring Robust and Multifunctional T Cell Responses

Subhra Mandal, Roel Hammink, Jurjen Tel, Zaskia H. Eksteen-Akeroyd, Alan E. Rowan, Kerstin Blank, and Carl G. Figdor

pp 485–492

Probing Interactions between Lysine Residues in Histone Tails and Nucleosomal DNA via Product and Kinetic Analysis

Liwei Weng, Chuanzheng Zhou, and Marc M. Greenberg

pp 622–630

January 2015: Volume 10, Issue 1

Issue on Protein Kinases

December 2014: Volume 9, Issue 12

Interfacing Chemical Biology and Drug Discovery: Report from the 50th International Conference on Medicinal Chemistry of the SCT (French Medicinal Chemistry Society), July 2–4, 2014, Rouen, France

Janos Sapi, Frédéric Schmidt, Luc Van Hijfte, and Pascal George

pp 2702–2707

Recent Progress in Design of Protein-Based Fluorescent Biosensors and Their Cellular Applications

Tomonori Tamura and Itaru Hamachi

pp 2708–2717

November 2014: Volume 9, Issue 11

Novel Imidazoline Antimicrobial Scaffold That Inhibits DNA Replication with Activity against Mycobacteria and Drug Resistant Gram-Positive Cocci

Kendra K. Harris, Allison Fay, Han-Guang Yan, Pratima Kunwar, Nicholas D. Socci, Narender Pottabathini, Ramakrishna R. Juventhala, Hakim Djaballah, and Michael S. Glickman

pp 2572–2583