Barta Patents and Publications

Patents and Publications:


Huang, Kenneth H.; Barta, Thomas E.; Rice, John W.; Smith, Emilie D.; Ommen, Andy J.; Ma, Wei; Veal James M.; Fadden, Patrick; Barabasz, Amy F.; Foley, Briana E.; Hughes, Philip F.; Hanson, Gunnar J.; Markworth, Christopher J.; Silinski, Melanie; Partridge, Jeffrey M.; Steed, Paul M. Hall, Steven E. “Discovery of Novel Aminoquinazolin-7-yl 6,7-dihydro-indol-4-ones as Potent, Selective Inhibitors of Heat Shock Protein 90” Bioorganic & Medicinal Chemistry Letters 2012, 22, 2550-2554.

Fobian, Yvette M.; Freskos, John N.; Barta, Thomas E.; Bedell, Louis J.; Heintz, Robert; Kassab, Darren J.; Kiefer, James R.; Mischke, Brent V.; Molyneaux, John M.; Mullins, Patrick; Munie, Grace E.; Becker, Daniel P.”MMP-13 Selective Alpha-sulfone Hydroxamates: Identification of Selective P1' Amides” Bioorganic & Medicinal Chemistry Letters 2011, 21, 2823-2825.

Barta, Thomas E.; Becker, Daniel P.; Bedell, Louis J.; Easton, Alan M.; Hockerman, Susan L.; Kiefer, James; Munie, Grace E.; Mathis, Karl J.; Li, Madeleine H.; Rico, Joseph G.; Villamil, Clara I.; Williams, Jennifer M.“MMP-13 Selective α-Sulfone Hydroxamates: A Survey of P1' Heterocyclic Amide Isosteres” Bioorganic & Medicinal Chemistry Letters 2011, 21, 2820-2822.

Becker, Daniel P.; Barta, Thomas E.; Bedell, Louis J.; Boehm, Terri L.; Bond, Brian R.; Carroll, Jeffery; Carron, Chris P.; De Crescenzo, Gary A.; Easton, Alan M.; Freskos, John N.; Funckes- Shippy, Chris L.; Heron, Marcia; Hockerman, Susan, L.; Howard, Carol P.; Kiefer, James R.; Li, Madeleine H.; Mathis, Karl J.; McDonald, Joseph J.; Mehta, Pramod P.; Munie, Grace E.; Sunyer, Teresa; Swearingen, Craig A.; Villamil, Clara I.; Welsch, Dean; Williams, Jennifer M.; Yu, Ying; Yao, Jun “Orally Active MMP-1 Sparing α-Tetrahydropyranyl and α-Piperidinyl Sulfone Matrix Metalloproteinase (MMP) Inhibitors with Efficacy in Cancer, Arthritis, and Cardiovascular Disease” Journal of Medicinal Chemistry 2010, 53, 6653-6680.

Fadden, Patrick; Huang, Kenneth H.; Veal, James M.; Steed, Paul M.; Barabasz, Amy F.; Foley, Briana; Hu, Mei; Partridge, Jeffrey M.; Rice, John; Scott, Anisa; DuBois, Laura G.; Freed, Tiffany A.; Silinski, Melanie A.; Barta, Thomas E.; Hughes, Philip F.; Ommen, Andrew; Ma, Wei; Smith, Emilie D.; Spangenberg, Angela W.; Eaves, Jeron; Hanson, Gunnar J.; Hinkley, Lindsay; Jenks, Matthew; Lewis, Meredith; Otto, James; Pronk, Gijsbertus; Verleysen, Katleen; Haystead, Timothy A. Hall, Steven E.“Application of Chemoproteomics to Drug Discovery: Identification of a Clinical Candidate Targeting Hsp90” Chemistry & Biology 2010, 17, 686- 694.

Huang, Kenneth H.; Veal, James W.; Fadden, R. Patrick; Rice, John W.; Eaves, Jeron;  Strachan, Jon-Paul; Barabasz, Amy F.; Foley, Briana E.; Barta, Thomas E.; Ma, Wei; Silinski, Melanie A.; Hu, Mei; Partridge, Jeffrey M.; Scott, Anisa; DuBois, Laura G.; Freed, Tiffany; Steed, Paul M.; Ommen, Andy J.; Smith, Emilie D.;  Hughes, Philip F.; Woodward, Angela R.; Hanson, Gunnar J.; McCall, W. Stephen; Markworth, Christopher J.; Hinkley, Lindsay; Jenks, Matthew; Geng, Lifeng; Lewis, Meredith; Otto, James; Pronk, Bert; Verleysen, Katleen; Hall, Steven E. "Discovery of Novel 2-Aminobenzamide Inhibitors of Heat Shock Protein 90 as Potent, Selective and Orally Active Antitumor Agents", Journal of Medicinal Chemistry, 2009, 52, 4288.


Barta, Thomas E.; Barabasz, Amy F.; Foley, Briana E.; Geng, Lifeng; Hall, Steven E.; Hanson, Gunnar J.; Jenks, Matthew; Ma, Wei; Rice, John W.; Veal, James M. "Novel Carbazole and Acyl-indole Antimitotics" Bioorganic and Medicinal Chemistry Letters, 2009, 3078.

Rice, John W.; Veal, James M.; Fadden, R. Patrick;, Barabasz, Amy F.; Partridge, Jeffrey M.; Barta, Thomas E.; Dubois, Laura G.; Huang, Kenneth H.; Mabbett, Sarah R.; Silinski, Melanie A.; Steed, Paul M.; Hall, Steven E. “Small Molecule Inhibitors of Hsp90 Potently Affect Inflammatory Disease Pathways and Exhibit Activity in Models for Rheumatoid Arthritis”, Arthritis and Rheumatism, 2008, 58, 3765.

Veal, James M.; Barta, Thomas E.; Rice, John W.; Partridge, Jeffrey M.; Fadden, Patrick; Ma, Wei; Jenks, Matthew; Geng, Lifeng; Hanson, Gunnar J.; Huang, Kenneth H.; Barabasz, Amy F.; Foley, Briana E.; Otto, James; Hall, Steven E. “Discovery of Benzamide Tetrahydro-4H-carbazol-4-ones as Novel Small Molecule Inhibitors of Hsp90” Bioorganic and Medicinal Chemistry Letters, 2008, 18, 3517.

Huang, Kenneth H.; Veal, James; Barta, Thomas; Smith, Emilie; Ma, Wei; Ommen, Andy, “Isoquinoline, Quinazoline, and Phthalazine Derivatives” WO/2008/024977

Huang, Kenneth H.; Hughes, Philip; Ma, Wei; Ommen, Andy; Woodward, Angela; Veal, James; Barta, Thomas, “Benzene, Pyridine, and Pyridazine Derivatives” WO/2008/024970

Huang, Kenneth H., Barta, Thomas; Smith, Emilie D.; Hall, Steven E.; Veal, James, “Benzene, Pyridine, and Pyridazine Derivatives” WO/2008/024963.

Huang, Kenneth H.; Hughes, Philip; Barta, Thomas; Veal, James, “Dihydropyridazine, Tetrahydropyridine, Chromanone, and Dihydronaphthalenone Derivatives as Heat-Shock Protein 90 Inhibitors” WO/2008/024961.

Huang, Kenneth H.; Eaves, Jeron; Hall, Steven E.; Barta, Thomas E.; Hanson, Gunnar J., “Cyclohexylamino, Benzene, Pyridine, and Pyridazine Derivatives” WO/2007/101156.

Hanson, Gunnar J.; Barta, Thomas E.; Geng, Lifeng; Huang, Kenneth H.; Veal, James, “Carbazole Derivatives” WO/2007/035620.

Huang, Kenneth H.; Eaves. Jeron; Veal, James; Barta, Thomas; Geng, Lifeng; Hinkley, Lindsey; Hanson, Gunnar, “Tetrahydroindolone and Tetrahydroindazolone Derivatives” US Patent 7,358,370, 2008.

Hanson, Gunnar J.; Ware, Roy W.; Barta, Thomas E.; Huang, Kenneth H., “2,8-Disubstituted Naphthyridine Derivatives” US Patent 7,282,506, 2007.

Hanson, Gunnar J.; Barta, Thomas E.; Veal, James M.; Ware, Roy W., “Methotrexate Derivatives Useful for Treating Cancer and Arthritis” WO/2006/014706.

Barta, Thomas E.; Becker, Daniel P.; Bedell, Louis J.: Boehm, Terri L.; Brown, David L.; Carroll, Jeffery N.; Chen, Yiyuan; Fobian, Yvette M.; Freskos, John N.; Gasiecki, Alan F.; Heintz, Robert M.; Hockerman, Susan L.; Kassab, Darren J.; Khanna, Ish K.; Kolodziej; Stephen A.; Massa, Mark A.; McDonald, Joseph J.; Mischke, Brent V.; Mischke, Deborah A.; Mullins, Patrick B.; Nagy, Mark A.; Norton, Monica B.; Rico, Joseph G.; Schmidt, Michelle A.; Stehle, Nathan W.; Talley, John J.; Vernier, William F.; Villamil, Clara I.; Wang, Lijuan J.; Wynn, Thomas A. “Piperidinyl- and Piperazinyl-sulfonylmethyl Hydroxamic Acids and their use as Protease Inhibitors” US Patent 7,119,203, 2006.

Bedell, Louis J.; McDonald, Joseph J.; Barta, Thomas E.; Becker, Daniel P.; Rao, Shashidhar N.; Getman, Daniel P.; DeCrescenzo, Gary A.; Villamil, Clara I. “Sulfonyl Aryl or Heteroaryl Hydroxamic Acid Compounds” US Patent 7,115,632, 2006.

Becker, Daniel P.; Villamil, Clara I.; Barta, Thomas E.; Bedell, Louis J.; Boehm, Terri L.; DeCrescenzo, Gary A.; Freskos, John N.; Getman, Daniel P.; Hockerman, Susan; Heintz, Robert; Howard, Susan C.; Li, Madeleine H.; McDonald, Joseph J.; Carron, Chris P.; Funcks-Shippy, Chris L.; Mehta, Pramod P.; Munie, Grace E.; Swearingen, Craig A., “Synthesis and Structure-Activity Relationships of b- and a- Piperidine Sulfone Hydroxamic Acid Metalloproteinase Inhibitors with Oral Antitumor Efficacy”, Journal of Medicinal Chemistry, 2005, 48, 6713.

Barta, Thomas E.; Becker, Daniel P.; Bedell, Louis J.; Boehm, Terri L.; Carroll, Jeffery N.; DeCrezcenzo, Gary A.; Fletcher, Theresa R.; Freskos, John N.; Getman, Daniel P.; Hanson, Gunnar J.; Hockerman, Susan L.; Howard, Carol P.; Kolodziej, Stephen A.; Li, Madeleine H.; McDonald, Joseph J.; Mischke, Deborah A.; Mullins, Patrick B.; Rico, Joseph G.; Stehle, Nathan W.; Villamil, Clara I., “Aromatic Sulfone Hydroxamic Acid Metalloprotease Inhibitors.” US Patent 6,890,937, 2005.

Freskos, John N.; Fobian, Yvette M.; Barta, Thomas E.; Becker, Daniel P.; Bedell, Louis J; Boehm, Terri L.; Carroll, Jeffrey N.; DeCrescenzo, Gary A.; Hockerman, Susan L.; Kassab, Darren J; Kolodziej, Steve A.; McDonald, Joseph; Mischke, Deborah A.; Norton, Monica B.; Rico, Joseph G.; Talley, John J.; Villamil, Clara I.; Wang, Lijuan Jane, “Aromatic Sulfone Hydroxamic Acids and their Use as Protease Inhibitors.” US Patent 6,890,928, 2005.

Bedell, Louis J.; McDonald, Joseph J.; Barta, Thomas E.; Becker, Daniel P.; Rao, Shashidhar N.; Freskos, John N.; Mischke, Brent V.; Getman, Daniel P.; DeCrescenzo, Gary A.; Villamil, Clara I., “Sulfonyl Aryl or Heteroaryl Hydroxamic Acid Compounds.” US Patent 6,794,511, 2004.

Barta, Thomas E.; Becker, Daniel P.; Bedell, Louis J.; Boehm, Terri L.; Carroll, Jeffery N.; DeCrescenzo, Gary A.; Fobian, Yvette M.; Freskos, John N.; Getman, Daniel P.; McDonald, Joseph J.; Hockerman, Susan L.; Howard, Susan C.; Kolodziej, Steve A.; Li, Hui; Mischke, Deborah A.; Rico, Joseph G.; Stehle, Nathan W.; Tollefson, Michael B.; Vernier, William F; Villamil, Clara I., “Aromatic Sulfone Hydroxamic Acid Metalloprotease Inhibitors” US Patent 6,750,233, 2004.

Barta, Thomas E.; Becker, Daniel P.; Bedell, Louis J.; Boehm, Terri L.; DeCrescenzo, Gary A.; Fobian, Yvette; Freskos, John N.; Li, Madeleine H.; Hockerman, Susan L.; Howard, Susan C.; Kolodziej, Stephen A.; Mischke, Deborah A.; Rico, Joseph G.; Stehle, Nathan W.; Tollefson, Michael B.; Vernier, William F.; Villamil, Clara I. “Aromatic Sulfone Hydroxamic Acid Metalloprotease Inhibitor” US Patent 6,750,228, 2004.

Barta, Thomas E.; Becker, Daniel P.; Bedell, Louis J.; DeCrescenzo, Gary A.; Freskos, John N.; Getman, Daniel P.; McDonald, Joseph J.; Mischke, Brent V..; Rao, Shashidhar N.; Villamil, Clara I., “Sulfonyl Aryl Hydroxamates and Their Use as Metalloprotease Inhibitors” US Patent 6,696,449, 2004.

Freskos, John N.; Fobian, Yvette M.; Barta, Thomas E.; Becker, Daniel P.; Bedell, Louis J.; Boehm, Terri L.; Carroll, Jeffery N.; DeCrescenzo, Gary A.; Hockerman, Susan L.;  Kassab, Darren J.;  Kolodziej; Steve A.; McDonald, Joseph J.; Mischke, Deborah A.; Norton, Monica B.; Rico, Joseph G.; Talley John J.; Villamil, Clara I.; Wang, Lijuan Jane, ”Aromatic Sulfone Hydroxamic Acids and their Use as Protease Inhibitors.” US Patent 6,689,794, 2004.

Barta, Thomas E.; Becker, Daniel P.; Bedell, Louis J.; Boehm, Terri L.; Carroll, Jeffery N.; DeCrescenzo, Gary A.; Fobian, Yvette M.; Freskos, John N.; Getman, Daniel P.; McDonald, Joseph J.; Li, Madeleine H.; Hockerman, Susan L.; Howard, Carol Pearcy, Kolodziej; Steve A.; Mischke, Deborah A.; Rico, Joseph G.; Stehle, Nathan W.; Tollefson, Michael B.; Vernier, William F.; Villamil, Clara I.; Kassab, Darren J.,”Aromatic Sulfone Hydroxamic Acids and their Use as Protease Inhibitors.” US Patent 6,683,093, 2004.

Barta, Thomas E.; Arner, Elizabeth C.; Becker, Daniel P.; Boehm, Terri L.; DeCrescenzo, Gary A.; McDonald, Joseph,” Use of Sulfonyl Aryl or Heteroaryl Hydroxamic Acids and Derivatives thereof as Aggrecanase Inhibitors.” US Patent 6,683,078, 2004.

Bedell, Louis J.; McDonald, Joseph J.; Barta, Thomas E.; Becker, Daniel P.; Rao, Shashidhar N.; Freskos, John N.; Mischke, Brent V.; Getman, Daniel P.; DeCrescenzo, Gary A., “Sulfonyl Divalent Aryl or Heteroaryl Hydroxamic Acid Compounds.” US patent 6,656,954, 2003.

Hockerman, Susan L; Becker, Daniel P.; Bedell, Louis; DeCrescenzo, Gary A.; Freskos, John N; Getman, Daniel; Heintz, Robert M; Li, Madeleine H; Mischke, Brent V; Villamil, Clara I; Barta, Thomas E., “Alpha.-Amino-.Beta.-Sulfonyl Hydroxamic Acid Compounds.” US Patent 6,583,299, 2003.

Barta, Thomas E.; Becker, Daniel P.; Boehm, Terri L.; De Crescenzo, Gary A.; Villamil; Clara I.; McDonald, Joseph J.; Freskos, John N.; Getman, Daniel P., “Aromatic Sulfone Hydroxamic Acid Metalloprotease Inhibitor.” US Patent 6,541,489, 2003.

Villamil, Clara I.; Freskos, John J.; Mischke, Brent V.; Mullins Patrick B.; Heintz, Robert M.; Getman, Daniel P.; McDonald. Joseph J.; DeCrescenzo, Gary A.; Barta, Thomas E.; Becker, Daniel P. “N-Hydroxy 4-Sulfonyl Butanamide Compounds” US Patent 6,476,027, 2002.

Weier, Richard M.; Collins, Paul W.; Stealey, Michael A.; Barta, Thomas E.; Huff, Renee M., “4-5-Substituted Imidazolyl Compounds for the Treatment of Inflammation.” US Patent 6,426,360, 2002.

Bedell, Louis J.; McDonald, Joseph J.; Barta, Thomas E.; Becker, Daniel P.; Rao, Shashi N.; Freskos, John N.; Mischke, Brent V.; Getman, Daniel P; De Crescenzo, Gary A. “Sulfonyl Divalent Aryl or Heteroaryl Hydroxamic Acid Compounds” US Patent 6,380,258, 2002.

Barta, Thomas E.; Becker, Daniel P.; Bedell, Louis J.; De Crescenzo, Gary A.; McDonald, Joseph J.; Mehta, Pramod; Munie, Grace E.; and Villamil, Clara I., “Selective, Orally Active MMP Inhibitors with an Aryl Backbone”, Bioorganic and Medicinal Chemistry Letters, 2001, 11, 2481.

Mueller, Richard A.; Partis, Richard A.; Koszyk, Francis J.; Barta, Thomas E.; McKearn, John P.; Gregory, Susan A., “Halogenated Phenylacetonitrile Alkylaminoalkylphenyl Compounds as Immunosuppressives.”US Patent 6,265,439, 2001.

Becker, Daniel. P.; Barta, Thomas. E.; Bedell, Louis J.; DeCrescenzo, Gary A.; Freskos, John N.; Getman, Daniel P.; Hockerman, Susan L.; Li, Madelleine H.; Mehta, Pramod.; Mischke, Brent V.; Munie, Grace E.; Swearingen, Craig; Villamil, Clara I. “a-Amino-b-sulfone Hydroxamates as Potent MMP-13 Inhibitors that Spare MMP-1” Bioorganic and Medicinal Chemistry Letters, 2001, 11, 2719.

Barta, Thomas E.; Becker, Daniel P.; T. L Boehm; De Crescenzo, Gary A.; Freskos, John N.; Getman, Daniel P.; Heintz, Robert M.; S. L. Hockerman; M. H. Li; B. V. Mischke; Villamil, Clara I., “Preparation of alpha-Amino-beta-sulfonyl Hydroxamic Acid Compounds as Matrix Metalloproteinase Inhibitors” WO 2000/71514, 2000.

Barta, Thomas E.; Becker, Daniel P.; Bedell, Louis J.; De Crescenzo, Gary A.; McDonald, Joseph J.; Munie, Grace E.; S. Rao; Shieh, H.; Stegeman, Roderick; Stevens, Anna M.; and Villamil, Clara I., “Synthesis and Activity of Selective MMP Inhibitors with an Aryl Backbone”, Bioorganic and Medicinal Chemistry Letters, 2000, 10, 2815.

Getman, Daniel P.; Becker, Daniel P.; Barta, Thomas E.; Villamil, Clara I.; S. L. Hockerman; Bedell, Louis J.; Li, Madelleine H.; Freskos, John N.; Heintz, Robert M.; McDonald Joseph J. ; DeCrescenzo, Gary A. , “Thioaryl Sulfonamide Hydroxamic Acid Compounds” US 6,087,359, 2000.

Barta, Thomas E.; Stealey, Micheal A.; Collins, Paul W. ; Weier, Richard W., “Antiinflammatory 4,5-Diarylimidazoles as Selective Cyclooxygenase Inhibitors”, Bioorganic and Medicinal Chemistry Letters, 1998, 8, 3443.

Barta, Thomas E.; Mueller, Richard A., “2-Chloro and 2-Bromo Derivatives of 1,5 Iminosugars.” US Patent 5,663,342, 1997.

Weier, Richard M.; Collins, Paul W.; Stealey, Micheal A.; Barta, Thomas E.; Huff, Renee M., “Benzenesulfonamide Substituted Imidazoyl Compounds for the Treatment of Inflammation.” US Patent 5,620,999, 1997.

Barta, Thomas E.; Mueller, Richard A., “2-Chloro and 2-Bromo Derivatives of 1,5 Iminosugars.” US Patent 5,612,480, 1997.

Barta, Thomas E.; Mueller, Richard A., “2-Chloro and 2-Bromo Derivatives of 1,5 Iminosugars.” US Patent 5,595,981, 1997.

Barta, Thomas E.; Mueller, Richard A., “2-Chloro and 2-Bromo Derivatives of 1,5 Iminosugars.” US Patent 5,451,679, 1995.

Mueller, Richard A.; Partis, Richard A.; Koszyk, Francis J.; Barta, Thomas E.; McKearn, John P.; Gregory, Susan A., “Halogenated Phenylacetonitrile Alkylaminoalkylphenyl Compounds as Immunosuppressives.” US Patent 5,451,604, 1995.

Boeckman, R.K., jr.; Barta, T.E.; Nelson, S.G. “Studies Directed Towards the Total Synthesis of Tetronolide 1. An Enantioselective Synthesis Of the Octahydronaphthalene Unit,” Tetrahedron Letters, 1991, 32, 4091.

Boeckman, R.K., jr.; Kamenecka, T.M.; Nelson, S.G; Pruitt, J.R.; Barta, T.E., “C-Phosphorylation of Enolates: An Alternative Route to Complex Carbonyl-Activated Phosphonates,” Tetrahedron Letters 1991, 2581.

Barrett, A.G.M.; Barta, T E.; Flygare, J.A.; Sabat, M; Spilling, C.D., “Approaches to Avermectin Assembly: A Concise Stereospecific Synthesis of the Hexahydrobenzofuran Entity,” J. Org. Chem., 1990, 55, 2409.

Barrett, A.G.M.; Barta, T.E.; Flygare, J.A.“4-[(tert-Butyldiphenylsilyl)oxy]-2-(tributylstannyl)-(E)-2-buten-1-ol: A Useful Precursor for Tetrahydrofuran Synthesis,” J.Org.Chem., 1989, 54, 4246.

Barrett, A.G.M.; Barta, TE.; Miller, T.D.; Raynham, T., “Advances in Avermectin Assembly,” Chem. in Australia 1987, 54, 290.

Boeckman, R.K., jr.; Barta, T. E. “Stereocontrol in the Intramolecular Diels-Alder Reaction. Use of the Trimethylsilyl Group as a Removable Stereocontrol Element to Provide Greatly Enhanced Levels of Diastereoselection, ” J. Org. Chem., 1985, 50, 3423.

Posters and Presentations:

Barta, Thomas E.* ; Barabasz, Amy; Eaves, Jeron; Foley, Brianna; Hall, Steve E.; Hanson, Gunnar J.; Huang, He; Jenks, Matthew; Ma, Wei; Ommen, Andrew; Partridge, Jeffery; Pronk, Bert; Rice, John; Scott, Anisa; Smith, Emilie; Steed, Paul "HSP90  at Serenex:  Proteomics to Phase I" Invited Oral Presentation at the ACS Great Lakes Regional Meeting, Chicago, IL, May 13-16, 2009. Abstract of Papers, MEDI 033.

Steed, Paul M.*; Huang, He; Fadden, Patrick; Barabasz, Amy; Barta, Thomas; Eaves, Jeron; Freed, Tiffany; Foley, Briana; Hu, Mei; Partridge, Jeffrey; Rice, John; Scott, Anisa; Silinski, Melanie; Hinkley, Lindsay; Hanson, Gunnar; Pronk, Bert; Veal, James; Hall, Steven “SNX-2112: A Novel, Selective, Potent Small Molecule Inhibitor of Hsp90 with Unique Pharmacodynamic Properties” EORTC-NCI-AACR conference, Prague, Cz, Nov. 2006

Villamil, Clara I.; Becker, Daniel P.; Barta, Thomas E.; Bedell, Louis J.; Talley, John J.; Hockerman, Susan L.; Munie, Grace E.; Boyce, Sharon Y.; Swearinger, Craig A.; Funckes-Shippy, Christie L.; DeCrescenzo, Gary A.; Heron, Marcia I.; Delyani, John A. “Design and Synthesis of MMP-13 Selective a-Sulphone Hydroxamates” 224th National Meeting of the American Chemical Society, Boston, MA, Aug. 18-22, 2002. Abstracts of Papers, MEDI 309

Hockerman, Susan L.*; Barta, Thomas E.; Becker, Daniel P.; Bedell, Louis J.; Boehm, Terri L.; DeCrescenzo, Gary A.; Freskos, John N.; Getman, Daniel P.; Li, Madeleine H.; Carron, Chris P.; Funckes-Shippy, Christie L.; Mehta, Pramod P.; Munie, Grace E.; Swearingen, Craig A. “Design and Synthesis of 4,4-Disubstituted Piperidine a-Sulphone Hydroxamates as Potent and Selective MMP Inhibitors: The Discovery of SC-77964” 222nd National Meeting of the American Chemical Society, Chicago, IL, Aug. 26-30, 2001. Abstracts of Papers, MEDI 258

Villamil, Clara I.*; Barta, Thomas E.; Becker, Daniel P.; Bedell, Louis J.; DeCrescenzo, Gary; Freskos, John N.; Getman, Daniel P.; Funckes-Shippy, Christie L.; Hockerman, Susan L.; Li, Madeleine H.; Mehta, Pramod P.; Munie, Grace E.; Swearingen, Craig A “Design and Synthesis of b-Sulfone and a-Sulfone Hydroxamates as Potent and Orally Active MMP Inhibitors” 222nd National Meeting of the American Chemical Society, Chicago, IL, Aug. 26-30, 2001. Abstracts of Papers, MEDI 259

Becker, Daniel P.*; Barta, Thomas E.; Bedell, Louis J.; Boehm, Terri L.; Carron, Chris P.; DeCrescenzo, Gary A.; Freskos, John N.; Funckes-Shippy, Christie L.; Getman, Daniel P.; Hockerman, Susan L.; Li, Madeleine H.; Mcdonald, Joseph; Mehta, Pramod P.; Munie, Grace E.; Rico, Joseph G.; Shieh, Huey S.; Stevens, Anna M.; Swearingen, Craig A.“Design and Synthesis of Potent and Orally Active MMP-1 Sparing Matrix Metalloproteinase inhibitors with Efficacy in Antitumor Models” Oral Presentation at the 222nd ACS National Meeting, Chicago, IL, August 26-30, 2001. Abstracts of Papers, MEDI 018.

Barta, Thomas E.*; Weier, Richard M.; Collins, Paul W.; Stealey, Micheal A. “Synthesis and Pharmacological Activity of Some 4,5-Diarylimidazole COX-2 Inhibitors” 216th National Meeting of the American Chemical Society, Boston, MA, Aug. 23-27, 1998.

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