Translational Bioinformatics | From Guideline to Practice to Impact
Dr. Overby's research is at the intersection of translational bioinformatics and implementation science. She seeks to develop new approaches for interpreting genome information and to understand processes and factors associated with the successful integration of approaches that support use of new evidence for clinical and shared decision-making.
Translational bioinformatics is "the development of storage, analytic, and interpretive methods to optimize the transformation of increasing voluminous biomedical data into proactive, predictive, preventative, and participatory health." (AMIA definition)
Implementation science is "the utilization of strategies or approaches to introduce or modify evidence-based interventions within specific settings. This involves the identification of and assistance in overcoming barriers to, the application of new knowledge obtained from a disseminated message or program." (Lomas, 1993)
Translational Research - Where Does Implementation Science & Research Fit?
Methods and Approaches
- Knowledge-based methods (knowledge acquisition, knowledge representation, inferencing and explanation)
- Designing and developing technologies
- Evaluations with healthcare providers and health IT professionals
- User studies (questionnaires, audio/video, experiments)
- Statistical methods
- Collaborations with Personalized & Genomic Medicine faculty, library scientists, computer scientists, designers and health services researchers