We engage the Portland, Oregon scientific and technical community to enhance the health of the scientific research enterprise, provide opportunities for the next generation of scientists and engineers, and promote the public's understanding of science and technology. We are comprised of faculty and students from several colleges and universities in the Portland area, as well as colleagues in local business, industry, federal and state agencies, and medical centers. We focus many of our programs on enhancing the experiences of students at all levels. Many of our members are retired scientists and engineers who have relocated to the Portland area and find a community of interests through the activities of the chapter.
Shake, Rattle, and Roll: Capturing Snapshots of Metalloenzymes in Action
Professor of Chemistry and Biology, Massachusetts Institute of Technology
Jean Dreyfus Boissevain Lecturer
Thursday, April 3, 2014, 8:00 pm
Willamette University, Ford Hall 122
This lecture is co-sponsored by the Dreyfus Foundation, Willamette University, the American Chemical Society Portland Chapter, and Sigma Xi Columbia-Willamette Chapter.
Metalloproteins are responsible for remarkable catalytic conversions such as the
reduction of ribonucleotides, the splitting of dinitrogen, and the fixation of carbon.
Here the conformational gymnastics involved in ribonucleotide reduction by
ribonucleotide reductases (RNRs) will be discussed. RNRs are key players in nucleic
acid metabolism, converting ribonucleotides to deoxyribonucleotides. As such, they
maintain the intracellular balance of deoxyribonucleotides to ensure the fidelity of
DNA replication and repair. The best-studied RNR is the Fe-dependent class Ia
enzyme from E. coli, which employs two subunits to catalyze its radical-based
reaction: β2 houses the diferric-tyrosyl radical cofactor and α2 contains the active
site. Recent applications of biophysical methods to the study of this RNR have revealed the importance of oligomeric state to overall enzyme activity, and suggest unprecedented subunit configurations are in play.
Dr. Drennan is a professor of chemistry and biology at the Massachusetts Institute of Technology, and a professor and investigator with the Howard Hughes Medical Institute. She received an A.B. in chemistry from Vassar College, working with Professor Miriam Rossi, and a Ph.D. in biological chemistry from the University of Michigan, working in the laboratory of the late Professor Martha L. Ludwig. She was also a postdoctoral fellow with Professor Douglas C. Rees at the California Institute of Technology. In 1999, she joined the faculty at the Massachusetts Institute of Technology, where she has risen through the ranks to full Professor. Extended abstract and bio.
was selected Outstanding Oregon Scientist for 2014 by the Oregon Academy of Science.
Save these dates!
March 15, 2014: application deadline for Sigma Xi Grants-In-Aid of Research.
March 17-23, 2014, Sigma Xi Student Research Showcase (online); registration deadline is March 10.
Thursday, April 3, 2014, 7:30 pm, Willamette University, Ford Hall 122: Catherine Drennan, Shake, Rattle, and Roll: Capturing Snapshots of Metalloenzymes in Action
Tuesday, April 15, 2014, Smith Memorial Union Ballroom: our chapter's 10th annual Student Research Symposium; abstracts must be submitted by Monday April 7.
Thursday, May 22, 2014, Smith Memorial Union 327-329: chapter annual meeting, banquet, initiation, awards, lecture (TBA).
June 17-20, 2014, AAAS Pacific Division meeting at UC Riverside. SX NW and SW Regions will attend and will sponsor a reception, make awards for student research, and hold an event for Sigma Xi members.