Vitamin D resources

 This page is to provide links to the most useful websites relating to Vitamin d research findings.

The Vitamin D Council Dr Cannel provides links to the latest research plus regular articles reporting on his personal response to the latest research findings. 

Direct MS org in the Information section of this site there are some useful presentations. This Reinhold Vieth: Prospects for Vitamin D Nutrition talk sets out a good resumee of the case for more vitamin D3 Cholecalciferol. Veith research papers are listed here and this Critique of the Considerations for Establishing Tolerable Upper Intake Levels for Vitamin D is essential reading for those wanting to understand why the Toxic Upper Limit needs changing.

Vitamin D and Influenza Powerpoint slide presentation detailing links between vitamin d status and colds/flu

Vitamin D and All Cause Mortality   Slide show detailing links between vitamin D status and all cause mortality

Top 10 Vitamin D Myths 

SUNLIGHT ROBBERY:

VitD-ez Duration of Vitamin D Synthesis in Human Skin calculator 

Prevalence of Severe Hypovitaminosis D in Patients With Persistent nonspecific musculoskeletal pain ...GREGORY A. PLOTNIKOFF, MD, MTS, AND JOANNA M. QUIGLEY, BA paper showing the amount of vitamin D insufficiency in people with pain.

Vitamin D Deficiency: What a Pain It Is MICHAEL F. HOLICK, MD  

Sun Exposure, Vitamin D Metabolism, and Skin Cancer Horlick's reply to criticism.

Fortification of food in Europe  

SUNARC - Sunlight, Nutrition And Heath Research Center Grant's website with cancer/MS maps. 

BIO-TECH Pharmacal Inc.
The best source of cholecalciferol (vitamin D3). Federally licensed and FDA approved manufacturer.

 Why we all need a little sunshine in our lives Independant article on benefits of sun exposure.

The Vitamin D miracle 

Michael Horlick Interview

Interesting letters in BMJ 

Whats a Vitamin D Deficiency?  Heaney video

Vitamin D and Cancer Prevention  Garland video

Connection with Vitamin D and Cancer    Donald Trump video

Skin Cancer/Sunscreen - the Dilemma Edward Gorham video particularly important for anyone thinking about sunscreens. 

sunscreens 

Are sunscreen’s worth buying.?

The above links show sunscreens are detectable in urine. The chemicals commonly used in sunscreens are absorbed through the skin and end up circulating in your blood stream. As they circulate in your blood, they go to your internal organs - where they do whatever those chemicals may do there. Then they are excreted in your urine. If you drink them the same thing would happen. It follows that the only sunscreens that you should really feel happy about using are those that contain ingredients you wouldn’t mind drinking and Sunblocks that have old style zinc or titanium oxide as their only active ingredients are not absorbed by the skin.

[url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&list_uids=15020197&dopt=Abstract]Agricultural workers are encouraged to use sunscreen to decrease the risk of UV-related skin cancer. This and other studies have shown certain commercial sunscreens to be[/url] So if you live in an area where crop spraying is a regular occurrence only use a sunscreen if you wish to increase your exposure.

These findings suggest that sunscreens may prevent redness partly by UV absorption and partly by inhibition of the skin's inflammatory response. Sunscreens might promote instead of protect against melanoma. What is happening is that the Sunscreens inhibit an enzyme in your skin that makes nitric acid and one of the functions of nitric acid is to inflame your skin. The inflammation then signals your immune system to start protecting your skin and tells you to get out of the sun. Sunscreens block nitric acid formation, the skin doesn't redden, the immune system isn't notified, you stay longer in the sun, your skin is damaged, and you increase your risk of skin cancer and premature aging.

So rather than using a sunscreen that may simply stay out in the sun for longer without appearing to burn I feel you may be best advised to increase the level of anti-inflammatory agent in you skin cells so that those cells are not only better able to generate Vitamin D but also less likely to burn. This is shown in this research The potential of omega-3 fatty acids in the prevention of non-melanoma skin cancer.

People who lived in the sun, like your ancestors in Africa, did not get sunburned. They were in the sun most of the day so their skin developed a natural sunscreen, melanin, which pigmented their skin black or brown. Today, most light skin people also deposit melanin in their skin on sun exposure; we call it a tan and it has always been a sign of good health. Diets rich in vegetables, fruits, and omega-3 fats - and the absence of appreciable quantities of omega-6 and trans-fats - also protects your skin from burning. The people who get sunburned are modern humans who live and work indoors, avoid fruit and vegetables, love french fries and chips, hate salmon, and go to the beach two or three times in the summer to roast themselves. Frequent sunburns, especially in childhood, are but one factor in melanoma; genetics, and diet are more important.

High vitamin D blood levels help prevent burning and facilitate tanning. I discovered that as I used a lot of vitamin d supplements during the winter as soon as it was warm enough to  start sunbathing I tanned straight away, however you have to be aware that the actual production of vitamin d is driven by skin temperature so without getting burnt it is better to sunbathe around midday when the ratio of UVB to UVA rays is higher and thus more likely to raise skin temperatures.

This article argues  green tea protects against not only sunburn but also melanoma

Extracts of green tea are effective chemopreventive agents for many of the adverse effects of sunlight on human health and may thus serve as natural alternatives for photoprotection. I appreciate that not everyone acquires a taste for green tea but if you know that it is also protecting you from the sunburn you may feel it’s worthwhile persisting.

There are further suggestions for ways in which diet can protect you from sunburn here How can my diet help protect me from sunburn?

Vitamin D rheumatoid arthritis.

Vitamin D intake is inversely associated with rheumatoid arthritis: Results from the Iowa Women's Health Study As greater intake of Vitamin D is associated with lower incidence of RA why isn't it plausible that greater intake is also associated with slower progression of the condition?
Clinical aspects of vitamin D in the management of rheumatoid arthritis patients with RA who are at high risk of vitamin D deficiency, correction of deficiency may be important in both the management of osteoporosis and modifying falls and fracture risk. Vitamin D supplementation in this patient group may also reduce RA disease activity, 

Clinicians should be aware of the issues surrounding interpretation of vitamin D levels and know the coefficients of variability of their local assay to allow interpretation of sequential measurements. The administration of high-dose vitamin D as an oral weekly bolus is safe and can rapidly correct vitamin D deficiency. Recommendations would therefore include bolus oral dosing (e.g. 2.5 mg/100 000 U vitamin D as described above), along with daily oral vitamin D tablets (with or without significant calcium), with monitoring and repeat dosing at regular intervals

Vitamin D and autoimmunity: new etiological and therapeutical considerations


Mounting Evidence for Vitamin D as an Environmental Factor Affecting Autoimmune Disease Prevalence

Vit D may exert immunomodulatory effects and hypovitaminosis D together with higher prevalence of RA seems common amongst North when compared to South Europe

Vitamin D intake is inversely associated with rheumatoid arthritis: results from the Iowa Women's Health Study.

Relationship between disease activity and serum levels of vitamin D metabolites and PTH in rheumatoid arthritis.

Vitamin D may exert immunomodulatory effects and hypovitaminosis D together with higher prevalence of RA seems common amongst north when compared to south Europe

our results indicate that 25(OH)D levels are inversely correlated with RA at least in terms of disease
activity, and that this has a circannual rhythm. In particular, low 25(OH)D values showed a moderately significant negative correlation with RA clinical status (DAS28) in summer in
southern European patients, whereas in Estonian RA patients the significant negative correlation was found in winter.
Latitude-related differences in the prevalence of autoimmune diseases such as RA might be partially linked to, among other factors, low serum levels of vitamin D, given the evidence that vitamin D may have immunosuppressive effects 


Don't forget also that higher levels of Vitamin D are associated with less pain