Dr McCleary's Brain Trust Program supplement list.
 

Dr McCleary's Anti-Excitatory Cocktail  To be taken twice daily.

400mg magnesium (malate or taurinate are the forms he suggests) 10mg Thiamin 75micrograms huperzine A 50mg GABA  5 mg vinpocetine 1gram taurine.

He also suggest Img melatonin at bedtime.

 

Dr McCleary's Ketogenic Cocktail.

1-2 tablespoons MCT oil                                                                                                                                                              1tsp-1tablespoon flaxseed oil                                                                                                                                                                 50mg EPA 

Dr McCleary's ANTI MIGRAINE Cocktail to be taken twice daily

400mg magnesium (malate or taurinate)                                                                                                1gTaurine                                                                                                                                                                                                           100mg Coenzyme Q10                                                                                                                        100mcghuperzineA                                                                                                                                                                                             1omg vinpocetine

 

I have been getting my supplement from the USA as the dollar is so low at the moment and prices are cheaper anyway in the States it works out about half price. I use IHERB but I've also used Vitacost, Vitaminshoppe, Vitaminlife and others. I prefer to use one that uses USPS rather than a carrier they are much cheaper. Newbies to importing have to be aware orders over £18 get VAT taxed on entry so keep your order value below £18 or not only will you have to pay Vat but to add insult to injury there will be a handling charge for collecting the money. If you want to save $5 off your first IHERB order  use referral code  WAB666

His list of supplement for general brain health include

His book The Brain Trust Program goes into more detail and stresses the importance of

  • OMEGA 3 1-2 grams daily preferably high EPA fish oil
  • KRILL oil 2-4 capsules
  • B group vitamins Thiamin 20mg riboflavin 20mg,  niacinaminde or nicotinamide 20mg,  pantothenic acid 20mg,  biotin 300mcg,  B6 pyridoxine 20mg, B12 Methylcobalamin, 100mcg folic acid, 800mcg choline 20mg
  • Magnesium 600mg (malate or taurinate) best taken at bedtime
  • Taurine 1g morning and night
  • Acetyl L-Carnitine 500mg
  • A-lipoic acid50-300mg daily 
  • Co Q 10 25-100mg
  • Vitamin D3 2000iu/daily (4000iu daily is required for optimal well-being and I find  5000iu is necessary during the winter in northern latitudes)
  • Huperzine A 75-100mcg twice daily
  • Vinpocetine5-10mg twice daily

My summary of Dr McCleary's Menopause section.

I've copied it from a forum post and that is what some of the comments allude to.

Understanding the process causing menopausal symptoms should enable effective action to be taken to control them.

I'm sorry my first post in this thread did not go into sufficient detail to enable readers to grasp the connection between low carbohydrate eating and the production of ketones as an alternative fuel for the brain to replace the defective glucose transport shuttle system caused by lowering estrogen levels.

So I will try again to explain the connection in more detail

We know there is a connection between an abrupt drop in reproductive hormone levels (whether as a result of surgery or as a consequence of natural menopause and Vasomotor instability (hot flashes brain fog night sweats) We know also that it isn't just low estrogen levels that are the cause, as young girls who don't have estrogen don't have hot flashes. It appears to be, the body gets used to having high estrogen for a prolonged period and it's the withdrawal of this estrogen that triggers the development of hot flashes. We might liken it to withdrawal symptoms from drug addiction.

Dr McCleary uses several rat model experiments to explain how he came to his understanding of which this a sketchy summary.

Blood sugar is carried to the brain by a shuttle transporter, That is how blood sugar reaches brain cells. Estrogen is responsible for generating these glucose shuttles. While there is estrogen available 40% more sugar gets transported across the blood brain barrier and into brain cells. When estrogen levels decline so does the glucose shuttle system. The brain cells become starved of energy. The hypothalamus then has to do something to fix the fuel shortage. It does this by releasing more nor-epinephrine, this acts to raise sugar levels in the blood, heart rate and body temperature. So we have a hot flash which is the outward sign of the brain protecting itself from blood sugar starvation.

But there is another impact resulting from the energy deficit. This is a build up of the brain signalling chemical Glutamate. Glutamate stimulates brain cells but when there is excess glutamate brain cells need more energy. When there is no source of energy available, that excess glutamate is adding an additional burden to the deprived brain cell.

You need energy to work your computer but a sudden surge of energy will throw the system completely and you'll lose data. So in the brain sudden changes causing excess energy demand and insufficient supplies can lead to damaged cells, brain fog memory loss.

So the hot flash is a countermeasure on the part of the energy starved brain to alleviate the situation by raising blood sugar level.

The solution is to use an alternative fuel for the brain to free it from it's dependence on glucose.

A ketogenic diet provides the brain with ketone bodies as an alternative fuel to replace the faulty estrogen controlled shuttle transport system. The brain cells need energy, they do not necessarily need to depend on glucose but the energy it represents.

Ketones are the result of burning fat. When we sleep at night we produce them while we sleep. We produce them when we don't eat for a long time and when we don't eat carbohydrate. When ketone are available brain cells will not become energy starved. So the faulty shuttle system is now irrelevant.

The point of the low carbohydrate diet in this case is not to lose weight (though that may be an advantage for some readers) but to provide and alternative fuel source for the brain. It's purpose is to prevent energy starvation in the brain and prevent the spiral of consequences the end in a hot flash. This dietary approach has no side effects, no medications and doesn't replace hormones.

By reducing the intake of everything that raises insulin you allow the fatty acids in your fat cells to flow out of those cells and be burnt as fuel. So limiting intake of bread, cereals, pasta, potatoes, sodas, and sweets your body will be better able to make ketones. You still have meat, fish poultry eggs cheese nuts fruits greens and non starchy veggies to eat so no one will be hungry.

If simply changing diet isn't sufficient then Dr McCleary suggests a ketogenic cocktail. I've put it on my website to save copying it out again. and there is also the Anti-excitatory cocktail. You will recall the section on surplus Glutamate causing excessive demands on the brain cells. This cocktail is to prevent, alleviate damage from that. GABA is a glutamate agonist, the others are to increase brain relaxation.

The point about using a low carb diet to generate ketones to serve as an alternative to glucose whose supply is restricted because of it's dependence on estrogen generated shuttle transporter to cross the brain/blood barrier, is to reduce the need for expensive supplements. However the supplement list is there for those for whom the low carb diet isn't sufficient on it's own.

Trying to summarise a ten page in-depth article to this length I have inevitably omitted certain sections and if this leaves anyone confused then I will try to answer any-one's questions if I can. But I am not a woman, I am not a health professional. I am mainly interested in Vitamin D3, and this is off my usual area of interest and expertise but as I am trying a low carb diet myself, I thought the relief of menopausal symptoms was was an interesting additional benefit to be derived from low carb eating, though not of course any use for me.

It would be interesting to hear from other low carbers who have noticed hot flash reduction.

Those consuming (as I did) a bottle of wine a day, will be adding to their insulin load and thus making the situation worse.

In order to make a smooth transition from using glucose from carbs to ketones from fat it may be worth using the ketogenic cocktail initially as simply cutting the carbs and hoping for ketone production may actually cause an increase in hot flashes until the ketone production gets going. It is a bit of a psychological adjustment thinking of fat as good. Taking one tablespoon of solid Coconut oil (for it's ability to generate Medium Chain Triglyceride's) seems counter-intuitive for someone trying to lose weight. I can only say it works.