Substance P

Cross references:    Neuropeptides   

Substance P  (Wiki)   
    "Substance P (SP) is an undecapeptide (a peptide composed of a chain of 11 amino acid residues) member of the tachykinin neuropeptide family. It is a neuropeptide, acting as a neurotransmitter and as a neuromodulator.[1][2] Substance P and its closely related neurokinin A (NKA) are produced from a polyprotein precursor after differential splicing of the preprotachykinin A gene.  
    The deduced amino acid sequence of substance P is as follows:[3]

    Arg Pro Lys Pro Gln Gln Phe Phe Gly Leu Met (RPKPQQFFGLM)

with an amidation at the C-terminus.[4] Substance P is released from the terminals of specific sensory nerves. It is found in the brain and spinal cord and is associated with inflammatory processes and pain. In 2014, the role of substance P to male aggression in fruit flies was identified.[5]"