Oxytocin Accumbens

Cross references:  Oxytocin        Oxytocin Receptors       
Oxytocin Receptor Distribution
Oxytocin Sociopathy    1<7 OxySoc      
276<278 OxRcpDistCite      
73<278 OxRcpDistCite    


Searching PubMed for "oxytocin accumbens" yielded 107 references. 

    My comment
    I'm surprised that such a complex molecule appeared so early in evolution.        

Oxytocin Accumbens - PubMed    Sorted by Recently Added   

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Deafferentation studies on the glutamic acid decarboxylase content of the supraoptic nucleus of the rat.
Meyer DK, Oertel WH, Brownstein MJ.
Brain Res. 1980 Oct 27;200(1):165-8.
PMID: 6998543   Related citations    

    "The localization of the GABAergic neurons which send efferent fibers to the supraoptic nucleus was investigated. For this purpose the activity of glutamic acid decarboxylase, a specific marker for GABAergic neurons, was determined in the supraoptic nucleus after a variety of lesions. The severance of fibers from the mesencephalon and the mediobasal hypothalamus, as well as from the hippocampus, had no effect. However, lesions rostral to the nucleus reduced its activity in glutamic acid decarboxylase by about 40%, as did the infusion of kainic acid into the nucleus accumbens.  Thus, the neurons in the supraoptic nucleus seem to receive a large part of their GABAergic afferents from the n. accumbens. In addition to that, GABAergic neurons intrinsic or adjacent to the supraoptic nucleus seem to contribute to the regulation of the release of vasopressin and/or oxytocin."  

Light microscopic autoradiographic localization of [3H]oxytocin binding sites in the rat brain, pituitary and mammary gland.
van Leeuwen FW, van Heerikhuize J, van der Meulen G, Wolters P.
Brain Res. 1985 Dec 16;359(1-2):320-5.
PMID:  4075153  Related citations
My comment
   Oxytocin receptors in many places, including the accumbens. 

Cellular mechanisms of social attachment.
Young LJ, Lim MM, Gingrich B, Insel TR.
Horm Behav. 2001 Sep;40(2):133-8. Review.
PMID: 11534973   Related citations  
Monogamous prairie voles have a higher density of oxytocin receptors in the nucleus accumbens than do nonmonogamous vole species; blockade of these receptors by site-specific injection of antagonist in the female prairie vole prevents partner preference formation.  
    Prairie voles also have a higher density of vasopressin receptors in the ventral pallidal area, which is the major output of the nucleus accumbens, than montane voles.    
    Both the nucleus accumbens and ventral pallidum are key relay nuclei in the brain circuits implicated in reward, such as the mesolimbic dopamine and opioid systems. Therefore, we hypothesize that oxytocin and vasopressin may be facilitating affiliation and social attachment in monogamous species by modulating these reward pathways."  

Nucleus accumbens oxytocin and dopamine interact to regulate pair bond formation in female prairie voles.
Liu Y, Wang ZX.
Neuroscience. 2003;121(3):537-44.
PMID: 14568015   Related citations   
In NAcc, blockade of OT receptors prevented partner preferences induced by a D2-type agonist whereas blockade of D2-type, but not D1-type, DA receptors blocked OT-induced partner preferences. Together, our data suggest that concurrent activation of OT and DA D2-type receptors in NAcc is essential for pair bond formation in female prairie voles." 

Social reward requires coordinated activity of nucleus accumbens oxytocin and serotonin.
Dölen G, Darvishzadeh A, Huang KW, Malenka RC.
Nature. 2013 Sep 12;501(7466):179-84. doi: 10.1038/nature12518.
PMID: 24025838  Related citations  
These results demonstrate that the rewarding properties of social interaction in mice require the coordinated activity of oxytocin and 5-HT in the nucleus accumbens"