GABA Testosterone

Cross references:   GABA     Testosterone    Criminal Testosterone   
Initiation of Locomotion in Lampreys    Inhibition of Locomotion in Lampreys   
Amphioxus GABA    
Lamprey GABA    Salamander GABA    
GABA/Glycine Inhibition    Tonic Inhibition   Behavioral Disinhibition    
Male Dominance Hierarchy      Endocrinology of Dominance      Sadism   


It occurred to me that the  Aggression  promoted by   Testosterone  requires at least some Behavioral Disinhibition  of the Tonic Inhibition  ascribed to GABA/Glycine Inhibition .  To look into this further, I've started this new page .


Searching PubMed for "gaba testosterone"  discovered 304 references.     
http://www.ncbi.nlm.nih.gov/pubmed/?term=gaba+testosterone  

1965    303<304 
Clinical data on a combination of gamma-aminobutyric acid and an androgen in psycho-neuro-endocrine disorders 
http://www.ncbi.nlm.nih.gov/pubmed/5860605   
Note:  This paper is in Portuguese, and there is no Abstract available.  What's more, although PubMed lists 140 "Similar articles", most of them are either not in English, or have no Abstract or both.  However, the titles explicit mention of both GABA and androgen make it of major interest to me, so I'm going to go ahead and look at the Similar articles to see if I can find anything helpful. 
Note:  I've reordered the references from the default "Sort by Link" to "Sort by Publication Date" which allows me to deal with them in chronological order. 


1982    43<140     
Free PMC Article   
Cerebrospinal fluid GABA levels in various neurological and psychiatric diseases. 
http://www.ncbi.nlm.nih.gov/pubmed/7086447   
    "
Cerebrospinal fluid gamma-aminobutyric acid (CSF-GABA) was analysed by radioreceptor assay in 16 normal controls and 84 patients with various neurological and psychiatric diseases. In patients with spinocerebellar degeneration, neuro-Behçet's syndrome and Parkinson's disease, CSF-GABA levels were decreased. On the other hand, increased CSF-GABA levels were detected in patients with meningitis."  
    My comment
No mention of testosterone in the full length PDF. 


2006    4<140     
Free PMC Article   
Antidepressants and violence: problems at the interface of medicine and law.  
http://www.ncbi.nlm.nih.gov/pubmed/16968128   
    My comment
No Abstract, but I skimmed the full article.  No mention of testosterone. 


I'm surprised I found so little.  I had expected much more. 



Searching PubMed for "testosterone nucleus accumbens " revealed 63 references: 
http://www.ncbi.nlm.nih.gov/pubmed/?term=testosterone+nucleus+accumbens  
    My overall commentary on all the references identified by this search: 
Although these references discuss "reward", none of them acknowledges that this reward is a manifestation of reduced  GABA/Glycine Inhibition  or  Tonic Inhibition  or an increase in  Behavioral Disinhibition .  


1981    61<63 
Differential effects of estrogen and androgen on locomotor activity induced in castrated male rats by amphetamine, a novel environment, or apomorph...  
http://www.ncbi.nlm.nih.gov/pubmed/7196275   
    "
It is suggested that the selective, facilitatory effect of E2 on drug- and novelty-induced locomotor activity resulted from increased postsynaptic receptor activation at dopaminergic synapses in the nucleus accumbens septi."  


1997    48<63  
Rewarding affective properties of intra-nucleus accumbens injections of testosterone.
 
http://www.ncbi.nlm.nih.gov/pubmed/9109641  
    "
The findings indicate that intra-accumbens injections of testosterone are sufficient to produce reward."   
    My comment
No mention that the "reward" is physiologically a reduction of  GABA/Glycine Inhibition 
or  Tonic Inhibition  or an increase in  Behavioral Disinhibition .
  


2002    38<63 
The nucleus accumbens as a site of action for rewarding properties of testosterone and its 5alpha-reduced metabolites 
http://www.ncbi.nlm.nih.gov/pubmed/12376159       
    "
These data are consistent with the hypothesis that the hedonic effects of T may be due to actions of its metabolites in the NA."  


2004    35<63 
Reinforcing aspects of androgens. - PubMed 
http://www.ncbi.nlm.nih.gov/pubmed/15488545   
    "
Nonetheless, androgen reinforcement is not comparable to that of cocaine or heroin. Instead, testosterone resembles other mild reinforcers, such as caffeine, nicotine, or benzodiazepines."  


2008    29<63 
Testosterone and nucleus accumbens dopamine in the male Syrian hamster. - PubMed 
http://www.ncbi.nlm.nih.gov/pubmed/18249072      
    "
We suggest that anabolic androgenic steroids (AAS) act via mechanism distinct from those of stimulants, but may share neural substrates with other drugs of abuse."  


2013    12<63 
'Roid rage in rats? Testosterone effects on aggressive motivation, impulsivity and tyrosine hydroxylase. 
http://www.ncbi.nlm.nih.gov/pubmed/23266798 
    "
Thus, although chronic high-dose testosterone enhances aggression, this does not include an increase in impulsive behavior or motivation to fight."     


2016    1<63      Free PMC Article   
Nucleus accumbens response to rewards and testosterone levels are related to alcohol use in adolescents and young adults. 
http://www.ncbi.nlm.nih.gov/pubmed/26771250       
    "
Prior research has demonstrated a link between testosterone and alcohol consumption, and between testosterone and neural responses to rewards."  

 

  


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