Cerebellar Neurotransmitters

Cross references:     Cerebellum         Deep Cerebellar Nuclei   
Cerebellar Afferent Pathways        Cerebellar Efferent Pathways   
Cerebellar Neurotransmitters      Tonic Inhibition     Cerebellum Tonic Inhibition   
GABA/Glycine Inhibition   
Behavioral Disinhibition      
Amphioxus Neurotransmitters    Lamprey Neurotransmitter 

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Perinatal Behavior
   
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Searching Google for "cerebellar neurotransmitters" identified 618,000 references:  
https://www.google.com/search?q=cerebellar+neurotransmitters&ie=utf-8&oe=utf-8  

Searching PubMed for "cerebellar neurotransmitters" identified 14, 554 references:  
https://www.google.com/search?q=cerebellar+neurotransmitters&ie=utf-8&oe=utf-8   

Searching PubMed for "cerebellar afferent neurotransmitters" identified 357 references:  
https://www.ncbi.nlm.nih.gov/pubmed/?term=cerebellar+afferent+neurotransmitters   

Searching PubMed for "cerebellar efferent neurotransmitters" identified 102 references:  
https://www.ncbi.nlm.nih.gov/pubmed/?term=cerebellar+efferent+neurotransmitters  



1966   355<357     Free PMC Article   
Acetylcholine sensitivity of cerebellar neurones in the cat.   

1973  
345<357     Free PMC Article   
Cutaneous convergence on to the climbing fibre input to cerebellar Purkynĕ cells.  

1973    344<357   
Free PMC Article   
Cortical and peripheral modification of cerebellar climbing fibre activity arising from cutaneous mechanoreceptors.   

1975   
335<357 
High affinity uptake of GABA in presumed GABA-ERGIC nerve endings in rat brain.   

1976   
330<357    Free PMC Article 
Noradrenaline modulation of the responses of the cerebellar Purkinje cell to afferent synaptic activity. 

1976   
329<357 
Characteristicas and response differences to iontophoretically applied norepinephrine, D-amphetamine and acetylcholine on neurons in the medial and lateral vestibular nuclei of the cat. 

1977   
324<357 
Functional organization of the vestibular input to the anterior and posterior cerebellar vermis of cat. 

1977   
323<357 
Interactions of antipsychotic drugs with norepinephrine and cerebellar neuronal circuitry: implications for the psychobiology of psychosis. 

1977   
321<357 
Ascending projections of the locus coeruleus in the rat. I. Axonal transport in central noradrenaline neurons 

1977   
320<357 
Acetylcholinesterase staining in subdivisions of the cat's inferior olive. 

1978   
317<357 
Afferent fiber connections from the lower brain stem to the rat cerebellum by the horseradish peroxidase method combined with MAO staining, with special reference to noradrenergic neurons. 

1978   
313<357 
The ventral spino-olivocerebellar system in the cat. IV. Spinal transmission after administration of clonidine and L-dopa. 

1980   
297<357 
Responses in the posterior lobe of the rat cerebellum to electrical stimulation of cutaneous afferents to the snout. 

1981   
292<357 
Ascending and cerebellar non-serotonergic projections from the nucleus raphe magnus of the rat. 

1981   
291<357 
Synaptic remodeling of serotonin axon terminals in rat agranular cerebellum. 

1981   
289<357 
Locus coeruleus stimulation potentiates Purkinje cell responses to afferent input: the climbing fiber system. 

1982   
285<357 
Locus coeruleus - cerebellum: interaction during development. 

1982   
283<357 
An immunohistochemical study of serotonin neuron development in the rat: ascending pathways and terminal fields. 

1982   
282<357 
Influences on drugs on evoked potentials in the cat cerebellum: I. Effects of CNS depressants and stimulants on the cerebellar afferent pathways.  

1985   
263<357 
An immunohistochemical study of serotonin development in the opossum cerebellum. 

1985   
260<357 
Interaction of norepinephrine with Purkinje cell responses to cerebellar afferent inputs in aged rats. 

1986   
245<357 
Cell bodies of origin of serotonin-immunoreactive afferents to the inferior olivary complex of the rat. 


1986    76<102 
Immunocytochemical localization of glutamate-, glutaminase- and aspartate aminotransferase-like immunoreactivity in the rat deep cerebellar nuclei. 

    "
Although the anatomy and the connectivity of the deep cerebellar nuclei have been well documented, little is known about the neurotransmitter systems mediating cerebellar efferent pathways.  
    The present study utilizes immunohistochemical procedures in conjunction with a novel monoclonal antibody specific for carbodiimide-fixed glutamate and polyclonal antisera against glutaminase (GLNase) and aspartate aminotransferase (AATase) to examine the presence of putative excitatory amino acid transmitters in neurons of the deep cerebellar nuclei. Carbodiimide-fixed glutamate-like, GLNase-like and AATase-like immunoreactivities were observed in neurons of the lateral, posterior interpositus, anterior interpositus and medial deep cerebellar nuclei. More neurons were stained with AATase antiserum than with the GLNase antiserum or the monoclonal antibody.  
    These results suggest glutamate, GLNase and AATase are present in neurons of the deep cerebellar nuclei and raise the possibility that glutamate may be an excitatory transmitter in these structures."  
    My comment
This doesn't distinguish between glutamate as an efferent transmitter and glutamate as a transmitter between interneurons.  


1989   
227<357 
Ontogenesis of enkephalinergic afferent systems in the opossum cerebellum. 

1990   
223<357 
Coexistence of corticotropin releasing factor and enkephalin in cerebellar afferent systems. 

1991   
214<357 
The cerebellar norepinephrine system: inhibition, modulation, and gating. 

1991   
212<357 
Physiological interactions between enkephalin and excitatory amino acids in the cerebellar cortex of the opossum Didelphis marsupialis virginiana. 

1991   
199<357 
Dopaminergic innervation and binding in the rat cerebellum. 

1992  196<357 
Cerebellar nuclei and the nucleocortical projections in the rat: retrograde tracing coupled to GABA and glutamate immunohistochemistry. 

1992   
194<357 
Autoradiographic localization of 5HT1 binding sites in the medulla oblongata of the rat. 

1992   
193<357    
Autoradiographic localization of 5HT1 binding sites in autonomic areas of the rat dorsomedial medulla oblongata. 

1992   
192<357 
Potentiation of mossy fiber-evoked EPSPs in turtle cerebellar Purkinje cells by the metabotropic glutamate receptor agonist 1S,3R-ACPD. 

1992   
191<357 
Synaptic excitation produces a long-lasting rebound potentiation of inhibitory synaptic signals in cerebellar Purkinje cells. 

1992   
186<357 
Role of metabotropic glutamate (ACPD) receptors at the parallel fiber-Purkinje cell synapse. 

1992   
185<357
Dopaminergic and non-dopaminergic neurons in the ventral tegmental area of the rat project, respectively, to the cerebellar cortex and deep cerebellar nuclei. 

1993   
182<357 
Excitatory amino acids as neurotransmitters of cortical and cerebellar projections to the red nucleus: an immunocytochemical study in the guinea pig. 

1993    181<357 
Neurotransmitters in the cerebellum. 


1993   
179<357 
Fine structure of the dorsal cap of the inferior olive and its GABAergic and non-GABAergic input from the nucleus prepositus hypoglossi in rat and rabbit. 

1993   
170<357 
Excitatory drive from deep cerebellar neurons to the superior colliculus in the rat: an electrophysiological mapping study.

1993   
169<357  
An analysis of GABAergic afferents to basket cell bodies in the cat's cerebellum. 

1994   
167<357
Cerebellar terminations in the red nucleus of Macaca fascicularis: an electron-microscopic study utilizing the anterograde transport of WGA:HRP. 

1994    164<357 

The origin of serotoninergic afferents to the cat's cerebellar nuclei. 

1995   
147<357 
Effects of serotonin on dorsal horn dorsal spinocerebellar tract neurons. 

1997   
128<357 
Cholinergic innervation and receptors in the cerebellum. 


2007    19<102   
Morphological and electrophysiological properties of GABAergic and non-GABAergic cells in the deep cerebellar nuclei.   
    "
The deep cerebellar nuclei (DCN) integrate inputs from the brain stem, the inferior olive, and the spinal cord with Purkinje cell output from cerebellar cortex and provide the major output of the cerebellum."  
Free Article   
    "
Within this classification, GABAergic neurons are thought to represent small local circuit neurons (that also contain glycine) and projection neurons targeting the inferior olive (IO), whereas glutamatergic neurons are equivalent to the large neurons projecting to red nucleus and other precerebellar sites."  
    "
Purkinje neurons can inhibit GABAergic DCN neurons and thereby disinhibit glutamatergic projection neurons.  A single Purkinje cell can innervate both glutamatergic and GABAergic cells and thus can have both an inhibiting and a disinhibiting effect on DCN output neurons."
    "
DCN neurons in vivo typically fire spontaneously at 35–55 Hz. During sensory stimulation or motor execution their firing frequency can reach hundreds of Hertz."  
    "
Our present work demonstrates that both GABAergic and non-GABAergic DCN neurons are intrinsically active."  
    My comment
    "Both inhibitory (GABA) and excitatory (glutamate) neurons are present.  However, they play different roles.  The inhibitory, GABAergic, neurons stay within the cerebellum.  They modulate the excitatory, glutamatergic, neurons which extend beyond the cerebellum and function as the over-all output.  Therefore, looking at the larger picture, the cerebellum is excitatory rather than inhibitory. "         


2014   
9<357 
Cerebellar afferents originating from the medullary reticular formation that are different from mossy, climbing or monoaminergic fibers in the rat. 

2014   
8<357 
5-HT2A receptor-mediated excitation on cerebellar fastigial nucleus neurons and promotion of motor behaviors in rats.









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