Somatic variant calling workflow for matched tumor-normal samples
Strelka is an analysis package designed to detect somatic SNVs and small indels from the aligned sequencing reads of matched tumor-normal samples.
The links on this page provide basic information on setting up, running and interpreting the results from this tool.
The method itself is described in the following publication:
Strelka: Accurate somatic small-variant calling from sequenced tumor-normal sample pairs.
Christopher T. Saunders; Wendy Wong; Sajani Swamy; Jennifer Becq; Lisa J. Murray; R. Keira Cheetham
Bioinformatics 2012; doi: 10.1093/bioinformatics/bts271
Please send any questions, comments or discussion related to the software or methods to the strelka-discuss mailing list.