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Nicholas Lartillot visit SciLifeLab, Nov 4 and 5

posted Oct 28, 2013, 5:14 AM by Lars Arvestad   [ updated Oct 29, 2013, 2:21 AM ]
Nicholas Lartillot will be the opponent at Joel Sjöstrand's thesis defence on Monday Nov 4 (at 13.30 in Inghesalen, Widströmska huset på KI, Tomtebodavägen 18). 

Tuesday Nov 5, Lartillot will give a presentation of his own work. This will be put into the calendar as soon as we know for sure we get the room we want.

Title: Reconstructing the evolution of the population-genetic environment and of life-history traits along phylogenies.
Date: Nov 5 (tuesday)
Time: 10:30
Place: Seminar room "Air" in the new Gamma building at SciLifeLab, Tomtebodavägen 23.

Substitution processes operating on DNA and protein sequences are influenced by selection, but also by effective population size as well as key parameters of the genetic system (mutation and recombination rates, strength of biased gene conversion). These variables are in turn correlated with life-history traits, such as body size or generation time. All these connections suggest that information can be extracted from sequence alignments about ancestral traits and population genetic environments, which can then be mapped onto phylogenetic trees.

In this direction, I will present a Bayesian probabilistic framework for modeling the macroevolutionary process in an integrative manner. The framework jointly estimates divergence times, life-history evolution and ancestral population genetic environments along the phylogeny. The application of the method to placental mammals reveals extensive correlations between life-history and molecular evolution, providing stimulating observations for testing macroevolutionary hypotheses.

Lars Arvestad