Current efforts in the lab are mainly directed towards studying the signal transduction pathways to activate and silence the Spindle Assembly Checkpoint (SAC), with particular focus on the regulation of assembly and disassembly of the Mitotic Checkpoint Complex (MCC). Knowledge about the SAC pathway will improve our understandings about initiation and development of many aneuploid tumors as well as cellular responses to mitosis-targeted cancer drugs.
In addition, we have maintained long-term interest in dissecting the composition, assembly, structure and function of the centromere/kinetochore complex, one of the major subcellular structures that contribute to high-fidelity chromosome segregation during cell division. Recent efforts have expanded to include research into several novel centrosomal proteins.
We are continuously looking for highly self-motivated colleagues. Inquiries to join the lab as postdoctoral researchers or graduate students are always welcome. Experience in biochemistry or light microscopy will be of great help, but education/research background in biophysics, engineering, computer science or chemistry can also be quite useful in our work.
Undergraduate students who are interested in adventures in lab research can stop by WO4254 anytime. The lab normally hosts only 2~4 undergraduate researchers to ensure proper personal attention. The undergraduate researchers are also strongly encouraged to pursue >1 academic year of research endeavor in order to get the most of the experience. Former undergraduate researchers have been co-authors on the publications from the lab.
The lab members have won American Society for Cell Biology Travel Award, UT First Year Undergraduate Research Fellowship, and awards in Ohio Junior Science and Humanities Symposium and Ohio Academy of Science District Science Day.
More on our Research.