Contact Information:
E-mail: simon.cheung@bristol.ac.uk
Position:
2023.12 – present Senior Research Associate, School of Earth Sciences, University of Bristol
2021.4 – 2023.1 Postdoctoral Fellow, Department of Microbiology, The Chinese University of Hong Kong
2019.2 – 2021.2 Postdoctoral Fellow, Department of Surgery, The Chinese University of Hong Kong
Education:
2013.8 – 2018.8 PhD (Biology), The Chinese University of Hong Kong
2005.8 – 2007.7 MPhil (Biology), The Chinese University of Hong Kong
2002.8 – 2005.7 BSc (Hons) (Biology), The Chinese University of Hong Kong
Research Interests:
1. Microbial ecology
2. Microbiome in health and disease
Peer-reviewed Publications (50 research papers and 2 reviews):
[2024]
52. Cai L, Zhu H, Mou Q, Wong PY, Lan L, Ng CWK, Lei P, Cheung MK, Wang D, Wong EWY, Lau EHL, Yeung ZWC, Lai R, Meehan K, Fung S, Chan KCA, Lui VWY, Cheng ASL, Yu J, Chan PKS, Chan JTK, Chen Z (2024). Integrative analysis reveals associations between oral microbiota dysbiosis and host genetic and epigenetic aberrations in oral cavity squamous cell carcinoma. npj Biofilms and Microbiomes, 10:39. [PDF] [link]
[2023]
51. Cheung MK, Ng RWY, Lai CKC, Zhu C, Au ETK, Yau JWK, Li C, Wong HC, Wong BCK, Kwok KO, Chen Z, Chan PKS, Lui GCY, Ip M (2023). Alterations in faecal microbiome and resistome in Chinese international travellers: a metagenomic analysis. Journal of Travel Medicine, 30:taad027. [PDF] [link] (Editor's choice)
50. Cheung MK*, Leung TF*, Tam WH, Leung ASY, Chan OM, Ng RWY, Yau JWK, Yuen CLY, Tong SLY, Ho WCS, Yeung ACM, Chen Z, Chan PKS (2023). Development of the early-life gut microbiome and associations with eczema in a prospective Chinese cohort. mSystems, 8:e00521-23. [PDF] [link] (*Equal contributions) (Featured in ASM Communications)
49. Cheung MK, Tong SLY, Wong MCS, Chan JYK, Ip M, Hui M, Lai CKC, Ng RWY, Ho WCS, Yeung ACM, Chan PKS, Chen Z (2023). Extent of oral–gut transmission of bacterial and fungal microbiota in healthy Chinese adults. Microbiology Spectrum, 11:e0281422. [PDF] [link]
48. Zhu H, Yip HC, Cheung MK, Chan HC, Ng C, Lau EHL, Yeung ZWC, Wong EWY, Leung L, Qu X, Wang D, Cai L, Chan PKS, Chan JYK, Chen Z (2023). Convergent dysbiosis of upper aerodigestive microbiota between patients with esophageal and oral cavity squamous cell carcinoma. International Journal of Cancer, 152:1903–1915. [PDF] [link]
47. Chiu PWY, Yue GGL, Cheung MK, Yip HC, Chu SK, Yung MY, Wu JCY, Chan SM, Teoh AYB, Ng EKW, Norimoto H, Lau CBS (2023). The effect of Andrographis paniculata water extract on palliative management of metastatic esophageal squamous cell carcinoma–A phase II clinical trial. Phytotherapy Research, 37:3438–3452. [PDF] [link]
[2022]
46. Cheung MK, Chan JYK, Wong MCS, Wong PY, Lei P, Cai L, Lan L, Ho WCS, Yeung ACM, Chan PKS, Chen Z (2022). Determinants and interactions of oral bacterial and fungal microbiota in healthy Chinese adults. Microbiology Spectrum, 10:e0241021. [PDF] [link]
45. Cheung MK, Yue GGL, Lauw S, Li CSY, Yung MY, Ng SC, Yip HC, Kwan HS, Chiu PWY, Lau CBS (2022). Alterations in gut microbiota of esophageal squamous cell carcinoma patients. Journal of Gastroenterology and Hepatology, 37:1919–1927. [PDF] [link]
44. Cheung MK, Yue GGL, Gomes AJ, Wong ECW, Lee JKM, Kwok FHF, Chiu PWY, Lau CBS (2022). Network pharmacology reveals potential functional components and underlying molecular mechanisms of Andrographis paniculata in esophageal cancer treatment. Phytotherapy Research, 36:1748–1760. [PDF] [link]
43. Lai CKC*, Cheung MK*, Lui GCY, Ling L, Chan JYK, Ng RWY, Chan HC, Yeung ACM, Ho WCS, Boon SS, Chan PKS, Chen Z (2022). Limited impact of SARS-CoV-2 on the human naso-oropharyngeal microbiota in hospitalized patients. Microbiology Spectrum, 10:e0219622. [PDF] [link] (*Equal contributions)
42. Chan JYK, Cheung MK, Lan L, Ng C, Lau EHL, Yeung ZWC, Wong EWY, Leung L, Qu X, Cai L, Zhu H, Boon SS, Burk RD, Chan PKS, Chen Z (2022). Characterization of oral microbiota in HPV and non-HPV head and neck squamous cell carcinoma and its association with patient outcomes. Oral Oncology, 135:106245. [PDF] [link]
41. Lin Q, Liu M, Yue GGL, Cheung MK, Lai Z, Kwok HF, Lee JKM, Wang Z, Lau CBS, Tan N (2022). Anti-inflammatory activities of natural cyclopeptide RA-XII in colitis-associated colon cancer mouse model and its effect on gut microbiome. Phytotherapy Research, 36:2641–2659. [PDF] [link]
[2021]
40. Yang H, Cheung MK, Yue GGL, Leung PC, Wong CK, Lau CBS (2021). Integrated network pharmacology analysis and in vitro validation revealed the potential active components and underlying mechanistic pathways of Herba Patriniae in colorectal cancer. Molecules, 26:6032. [PDF] [link]
39. Tang Y, Ma KY, Cheung MK, Yang C-H, Wang Y, Hu X, Kwan HS, Chu KH (2021). Gut microbiota in decapod shrimps: evidence of phylosymbiosis. Microbial Ecology, 82:994–1007. [PDF] [link]
38. Zhang J, Shen N, Li C, Xiang X, Liu G, Gui Y, Patev S, Hibbett DS, Barry K, Andreopoulos W, Lipzen A, Riley R, He G, Yan M, Grigoriev IV, Kwan HS, Cheung MK, Bian Y, Xiao Y (2021). Population genomics provides insights into the genetic basis of adaptive evolution in the mushroom-forming fungus Lentinula edodes. Journal of Advanced Research, 38:91–106. [PDF] [link]
37. Zhang L, Gong W, Li C, Shen N, Gui Y, Bian Y, Kwan HS, Cheung MK, Xiao Y (2021). RNA-Seq-based high-resolution linkage map reveals the genetic architecture of fruiting body development in shiitake mushroom, Lentinula edodes. Computational and Structural Biotechnology Journal, 19:1641–1653. [PDF] [link]
[2020]
36. Cheung MK, Yue GGL, Tsui KY, Gomes AJ, Kwan HS, Chiu PWY, Lau CBS (2020) Discovery of an interplay between the gut microbiota and esophageal squamous cell carcinoma in mice. American Journal of Cancer Research, 10:2409–2427. [PDF] [link]
35. Cheung MK, Yue GGL, Chiu PWY, Lau CBS (2020) A review of the effects of natural compounds, medicinal plants and mushrooms on the gut microbiota in colitis and cancer. Frontiers in Pharmacology, 11:744. (Review) [PDF] [link]
34. Tsang KSW*, Cheung MK*, Lam RYC, Kwan HS (2020) A preliminary examination of the bacterial, archaeal and fungal rhizosphere microbiome in healthy and Phellinus noxius infected trees. MicrobiologyOpen, 9:e1115. (*Equal contributions) [PDF] [link]
33. Lau AYT, Xie Y, Cheung MK, Cheung PCK, Kwan HS (2020) Genome-wide mRNA and miRNA analysis during basidiospore germination and outgrowth in Coprinopsis cinerea. Fungal Genetics and Biology, 142:103416. [PDF] [link]
[2019]
32. Zheng XL, Gong WB, Li C, Zhang L, Bian YB, Kwan HS, Cheung MK, Xiao Y (2019) Comprehensive evaluation of shiitake strains (Lentinus edodes, Agaricomycetes) based on polysaccharides content and agronomic traits. International Journal of Medicinal Mushrooms, 21:851–864. [PDF] [link]
31. Chang J, Chan KPL, Xie Y, Ma KL, Cheung MK, Kwan HS (2019) Modified recipe to inhibit fruiting body formation for living fungal biomaterial manufacture. PLOS ONE, 14:e0209812. [PDF] [link]
[2018]
30. Cheung MK, Wong CK, Chu KH, Kwan HS (2018) Community structure, dynamics and interactions of bacteria, archaea and fungi in subtropical coastal wetland sediments. Scientific Reports, 8:14397. [PDF] [link]
29. Lau AYT, Cheng X, Cheng CK, Nong W, Cheung MK, Chan RH-F, Hui JHL, Kwan HS (2018) Discovery of microRNA-like RNAs during early fruiting body development in the model mushroom Coprinopsis cinerea. PLOS ONE, 13:e0198234. [PDF] [link]
28. Gong WB, Li L, Zhou Y, Bian YB, Kwan HS, Cheung MK, Xiao Y (2018) Detection of quantitative trait loci underlying yield-related traits in shiitake culinary-medicinal mushroom, Lentinus edodes (Agaricomycetes). International Journal of Medicinal Mushrooms, 20:451–458. [PDF] [link]
[2017]
27. Wang L, Cheung MK, Liu R, Wong CK, Kwan HS, Hwang J-S (2017) Diversity of total bacterial communities and chemoautotrophic populations in sulfur-rich sediments of shallow-water hydrothermal vents off Kueishan Island, Taiwan. Microbial Ecology, 73:571–582. [PDF] [link]
26. Ho TW, Hwang J-S, Cheung MK, Kwan HS, Wong CK (2017) DNA-based study of the diet of the marine calanoid copepod Calanus sinicus. Journal of Experimental Marine Biology and Ecology, 494:1–9. [PDF] [link]
25. Keung HY, Li TK, Sham LT, Cheung MK, Cheung PCK, Kwan HS (2017) Mechanistic study of utilization of water-insoluble Saccharomyces cerevisiae glucans by Bifidobacterium breve strain JCM1192. Applied and Environmental Microbiology, 83:e03442–16. [PDF] [link]
24. Li C, Gong WB, Zhang L, Yang ZQ, Nong W, Bian YB, Kwan HS, Cheung MK, Xiao Y (2017) Association mapping reveals genetic loci associated with important agronomic traits in Lentinula edodes, shiitake mushroom. Frontiers in Microbiology, 8:237. [PDF] [link]
[2016]
23. Lam WY, Cheung MK, Fung WYW, Law PTW, Kam KM, Au CH, Nong W, Hwang D, Chan RCY, Kwan HS, Tsui SKW (2016) Metagenomics of tuberculosis infection in Hong Kong. Hong Kong Medical Journal, 22:15–17. [PDF] [link]
22. Gong WB, Li L, Zhou Y, Bian YB, Kwan HS, Cheung MK, Xiao Y (2016) Genetic dissection of fruiting body-related traits using quantitative trait loci mapping in Lentinula edodes. Applied Microbiology and Biotechnology, 100:5437–5452. [PDF] [link]
21. Xiao Y, Chen X, Liu J, Li C, Nong W, Bian Y, Cheung MK, Kwan HS (2016) Population genomic analysis uncovers environmental stress-driven selection and adaptation of Lentinula edodes population in China. Scientific Reports, 6:36789. [PDF] [link]
20. Xiang XJ, Li C, Li L, Bian YB, Kwan HS, Nong W, Cheung MK, Xiao Y (2016) Genetic diversity and population structure of Chinese Lentinula edodes revealed by InDel and SSR markers. Mycological Progress, 15:37. [PDF] [link]
[2015]
19. Cheung MK, Yip HY, Nong W, Law PTW, Chu KH, Kwan HS, Hui JHL (2015) Rapid change of microbiota diversity in the gut but not the hepatopancreas during gonadal development of the new shrimp model Neocaridina denticulata. Marine Biotechnology, 17:811–819. [PDF] [link]
18. Cheng CK*, Cheung MK*, Nong W, Law PTW, Qin J, Ling JML, Kam KM, Cheung WMW, Kwan HS (2015) Next generation genome sequencing reveals phylogenetic clades with different level of virulence among Salmonella Typhimurium clinical human isolates in Hong Kong. BMC Genomics, 16:688. (*Equal contributions) [PDF] [link]
17. Wang L, Cheung MK, Kwan HS, Hwang J-S, Wong CK (2015) Microbial diversity in shallow-water hydrothermal sediments of Kueishan Island, Taiwan as revealed by pyrosequencing. Journal of Basic Microbiology, 55:1308–1318. [PDF] [link]
16. Ho TW, Hwang J-S, Cheung MK, Kwan HS, Wong CK (2015) Dietary analysis on the shallow-water hydrothermal vent crab Xenograpsus testudinatus using Illumina sequencing. Marine Biology, 162:1787–1798. [PDF] [link]
[2014]
15. Huang Q, Chang J, Cheung MK, Nong W, Li L, Lee MT, Kwan HS (2014) Human proteins with target sites of multiple post-translational modification types are more prone to be involved in disease. Journal of Proteome Research, 13:2735–2748. [PDF] [link]
14. Li L, Wong H-C, Nong W, Cheung MK, Law PTW, Kam KM, Kwan HS (2014) Comparative genomic analysis of clinical and environmental strains provides insight into the pathogenicity and evolution of Vibrio parahaemolyticus. BMC Genomics, 15:1135. [PDF] [link]
13. Yang Y, Zhang G, Sun Z, Cheung MK, Huang C (2014) Altererythrobacter oceanensis sp. nov., isolated from the Western Pacific. Antonie Van Leeuwenhoek, 106:1191–1198. [PDF] [link]
12. Gong WB, Liu W, Lu YY, Bian YB, Zhou Y, Kwan HS, Cheung MK, Xiao Y (2014) Constructing a new integrated genetic linkage map and mapping quantitative trait loci for vegetative mycelium growth rate in Lentinula edodes. Fungal Biology, 118:295–308. [PDF] [link]
[2013]
11. Cheung MK*, Lam WY*, Fung WYW*, Law PTW, Au CH, Nong W, Kam KM, Kwan HS, Tsui SKW (2013) Sputum microbiota in tuberculosis as revealed by 16S rRNA pyrosequencing. PLoS ONE, 8:e54574. [PDF] [link] (*Equal contributions)
10. Cheung MK, Nong W, Kwan HS, Wong CK (2013) Composition of heterotrophic flagellates in coastal waters of different trophic status. Current Microbiology, 67:351–355. [PDF] [link]
09. Au CH*, Cheung MK*, Wong MC, Chu AKK, Law PTW, Kwan HS (2013) Rapid genotyping by low-coverage resequencing to construct genetic linkage maps of fungi: a case study in Lentinula edodes. BMC Research Notes, 6:307. (*Equal contributions) [PDF] [link]
08. Wong KS, Cheung MK, Au CH, Kwan HS (2013) A novel Lentinula edodes laccase and its comparative enzymology suggest guaiacol-based laccase engineering for bioremediation. PLoS ONE, 8:e66426. [PDF] [link]
07. Li L, Huang D, Cheung MK, Nong W, Huang Q, Kwan HS (2013) BSRD: a repository for bacterial small regulatory RNA. Nucleic Acids Research, 41:D233–D238. [PDF] [link]
[2008-2012]
06. Cheung MK, Kwan HS (2012) Fighting outbreaks with bacterial genomics: case review and workflow proposal. Public Health Genomics, 15:341–351. (Review) [PDF] [link]
05. Huang Q, Cheng X, Cheung MK, Kiselev SS, Ozoline ON, Kwan HS (2012) High-density transcriptional initiation signals underline genomic islands in bacteria. PLoS ONE, 7:e33759. [PDF] [link]
04. Cheung MK, Li L, Nong W, Kwan HS (2011) 2011 German Escherichia coli O104:H4 outbreak: whole-genome phylogeny without alignment. BMC Research Notes, 4:533. [PDF] [link]
03. Cheung MK*, Au CH*, Chu KH, Kwan HS, Wong CK (2010) Composition and genetic diversity of picoeukaryotes in subtropical coastal waters as revealed by 454 pyrosequencing. The ISME Journal, 4:1053–1059. [PDF] [link] (*Equal contributions)
02. Tsang LM, Chan T-Y, Cheung MK, Chu KH (2009) Molecular evidence for the Southern Hemisphere origin and deep-sea diversification of spiny lobsters (Crustacea: Decapoda: Palinuridae). Molecular Phylogenetics and Evolution, 51:304–311. [PDF] [link]
01. Cheung MK, Chu KH, Li CP, Kwan HS, Wong CK (2008) Genetic diversity of picoeukaryotes in a semi-enclosed harbour in the subtropical western Pacific Ocean. Aquatic Microbial Ecology, 53:295–305. [PDF] [link]
Other Publications:
8. Cheung MK (2021) Pandemic haiku. Science, 373:22–23. (Letters to the Editor) [PDF] [link]
7. Cheung MK (2018) Education for the future. Science, 360:1409–1412. (Letters to the Editor) [PDF] [link]
6. Cheung MK (2017) Facilitating conservation. Science, 356:242–244. (Letters to the Editor) [PDF] [link]
5. Cheung MK (2016) Research night owls. Science, 354:964–966. (Letters to the Editor) [PDF] [link]
4. Cheung MK (2013) Human infection with H7N9 virus. The New England Journal of Medicine, 369:879–880. (Correspondence) [PDF] [link]
3. Cheung MK (2013) Altmetrics: too soon for use in assessment. Nature, 494:176. (Correspondence) [PDF] [link]
2. Cheung MK (2013) Science time travel. Science, 341:28–30. (Letters to the Editor) [PDF] [link]
1. Li L, Cheng CK, Cheung MK, Law PTW, Ling JML, Kam KM, Cheung WMW, Kwan HS (2012) Draft genome sequence of Salmonella enterica serovar Typhimurium ST1660/06, a multidrug-resistant strain isolated from a clinical diarrheic patient. Journal of Bacteriology, 194:6319–6320. (Genome Announcement) [PDF] [link]
Manuscripts in prep:
1. Blewett J, Vreeken M, Harris R, Cheung MK, Gallego-Sala AV, Agudo D, Naafs BDA, Bryce C, Pearson A, Pancost RD.
Conference Presentations:
3. Cheung MK, Wong CK, Chu KH, Kwan HS (2016) Diversity and distribution of microbial communities in subtropical coastal wetland sediments. ASM Microbe 2016. Boston, Massachusetts, USA. (Poster)
2. Cheung MK, Wong CK, Chu KH (2007) Spatial and seasonal variabilities of picoeukaryote communities in a subtropical eutrophic coastal ecosystem based on analysis of 18S rDNA sequences. ASLO 2007 Aquatic Sciences Meeting. Santa Fe, New Mexico, USA. (Oral)
1. Cheung MK, Wong CK, Chu KH (2006) Study of picoeukaryote community compositions in Hong Kong waters using SSU rRNA gene cloning and sequencing. The 2nd MBAHK Postgraduate Symposium. The Hong Kong University of Science and Technology (HKUST), Hong Kong. (Oral)
Professional Service:
1. Journal reviewer (In alphabetical order):
Academic Psychiatry
Animals
Aquaculture
Archives of Microbiology
BMC Genomics
Cancer Medicine
Cancers
Communications Biology
FEMS Microbiology Letters
Frontiers in Ecology and Evolution
Frontiers in Marine Science
Frontiers in Microbiology
Frontiers in Oncology
Frontiers in Pharmacology
Frontiers in Plant Science
Gene
Genomics
Gut Pathogens
International Journal of Biological Macromolecules
International Journal of Environmental Research and Public Health
International Journal of Molecular Sciences
Journal of Gastroenterology and Hepatology
Journal of Oral Microbiology
Marine Biotechnology
MethodX
Microbial Ecology
Microbiology Spectrum
Microorganisms
Nordic Journal of Botany
PeerJ
Pharmaceutical Biology
Phytomedicine
Phytotherapy Research
PLOS ONE
SAR and QSAR in Environmental Research
Saudi Journal of Biological Sciences
Science of the Total Environment
Wetlands
2. Academic editor:
3. Review editor:
Frontiers in Ecology and Evolution
Frontiers in Marine Science
Frontiers in Microbiology
External Links:
University of Bristol profile / Google Scholar / ORCID / ResearchGate / Loop / ResearcherID / Scopus / LinkedIn
Note: PDFs are for personal use only.
Last modified: 5 May 2024