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Pharmaceutical

posted Mar 4, 2011, 8:09 AM by rajesh gk

Title

Antioxidative flavonoids from the leaves of Morus alba.

Authors

Kim SY, Gao JJ, Lee WC, Ryu KS, Lee KR, Kim YC.

Dept. of Sericulture & Entomology, National Institute Agricultural Science and Technology, RDA, Suwon, Korea.

Journal

Arch Pharm Res. 1999 Feb;22(1):81-5.

Abstract

Nine flavonoids (1-9) were isolated from the leaves of Morus alba (Moraceae). The structures of compounds were determined to be kaempferol-3-O-beta-D-glucopyranoside (astragalin, 1) kaempferol-3-O-(6"-O-acetyl)-beta-D-glucopyranoside (2), quercetin-3-O-(6"-O-acetyl)-beta-D-glucopyranoside (3), quercetin-3-O-beta-D-glucopyranoside (4), kaempferol-3-O-alpha-L-rhamnopyranosyl-(1-->6)-beta-D-glucopyranoside (5), quercetin-3-O-alpha-L-rhamnopyranosyl-(1-->6)-beta-D-glucopyranoside (rutin, 6), quercetin-3-O-beta-D-glucopyranosyl-(1-->6)-beta-D-glucopyranoside (7), quercetin-3,7-di-O-beta-D-glucopyranoside (8) and quercetin (9) on the basis of spectroscopic and chemical studies. Compounds 7 and 9 exhibited significant radical scavenging effect on 1,1-diphenyl-2-picrylhydrazyl radical.

Citation

http://www.ncbi.nlm.nih.gov/pubmed/10071966 PMID: 10071966 [PubMed - indexed for MEDLINE]

 

Title

Mulberry (Morus alba) leaves as human food: a new dimension of sericulture.

Authors

Srivastava S, Kapoor R, Thathola A, Srivastava RP.

Department of Foods and Nutrition, College of Home Science Govind Ballabh Pant University of Agriculture and Technology, U.S. Nagar, Uttaranchal, India.

Journal

Int J Food Sci Nutr. 2003 Nov;54(6):411-6.

Abstract

Mulberry leaf is commonly used for sericulture in almost every part of the world but its potential to be utilized for human consumption is not well recognized. This paper deals with development of mulberry leaf powder and its use with wheat flour to develop paratha, the most common food item of breakfast and dinner in the Indian diet. The optimum ratio of the mulberry leaf powder and wheat flour (MLP-WF) mix for preparation of paratha on the basis of sensory quality was found to be 1:4. The protein quality of the MLP-WF mix was estimated by measuring the Protein Efficiency Ratio, and was found to be 1.82 against a casein diet for which a value of 2.44 was observed. The in vivo toxic effect of mix was studied and no adverse effect on the growth of internal organs of rats (heart, liver, kidney and testes) was found. The storage stability of the mix was estimated for a period of 2 months in polyethylene bags at room temperature. A non-significant difference was observed between paratha prepared from fresh and stored mix. This indicated that mix can be stored for a period of 2 months at room temperature without loss of quality.

Citation

http://www.ncbi.nlm.nih.gov/pubmed/14522686 PMID: 14522686 [PubMed - indexed for MEDLINE]

 

Title

[Advances in the study and development of medical uses of sericulture and mulberry resources]

[Article in Chinese]

Authors

Chen W, Xiao G, Liao S.

Institute of Sericulture, Guangdong Provincial Academy of Agricultural Sciences, Guangzhou, 510640

Journal

Zhong Yao Cai. 1999 Sep;22(9):481-4.

Abstract

http://www.ncbi.nlm.nih.gov/pubmed/12908502

Citation

PMID: 12908502 [PubMed - indexed for MEDLINE]

 

Title

Two chitinase-like proteins abundantly accumulated in latex of mulberry show insecticidal activity

Authors

Kitajima Sakihito ; Kamei Kaeko ; Taketani Shigeru ; Yamaguchi Masamitsu ; Kawai Fumiko ; Komatsu Aino ; Inukai Yoshihiro

Journal

BMC Biochemistry, 2010; 11(1) p. 6

Abstract

Background: Plant latex is the cytoplasm of highly specialized cells known as laticifers, and is thought to have a critical role in defense against herbivorous insects. Proteins abundantly accumulated in latex might therefore be involved in the defense system.

Results: We purified latex abundant protein a and b (LA-a and LA-b) from mulberry (Morus sp.) and analyzed their properties. LA-a and LA-b have molecular masses of approximately 50 and 46 kDa, respectively, and are abundant in the soluble fraction of latex. Western blotting analysis suggested that they share sequence similarity with each other. The sequences of LA-a and LA-b, as determined by Edman degradation, showed chitin-binding domains of plant chitinases at the N termini. These proteins showed small but significant chitinase and chitosanase activities. Lectin RCA120 indicated that, unlike common plant chitinases, LA-a and LA-b are glycosylated. LA-a and LA-b showed insecticidal activities when fed to larvae of the model insect Drosophila melanogaster.

Conclusions: Our results suggest that the two LA proteins have a crucial role in defense against herbivorous insects, possibly by hydrolyzing their chitin.

Citation

FULL TEXT

 

Title

Structure and Property of Mulberry Fiber

Authors

Ruili Cong ; Weiguo Dong

Journal

Modern Applied Science, 2009, 1(4)

Abstract

In this paper, the chemical ingredients of mulberry bast was tested by quantitative analysis. Our objective was to <br />substitute the slow and difficult to control retting process by a fast and well controlled process, i.e. the two-step boiled <br />process treatment (TSBP) of mulberry bast which was treated by mechanism. During the TSBP treatment the pectin, <br />Lignin and hemicelluloses are hydrolysed and rendered in water or alkali-soluble, the fibers being more easily <br />degummed. The TSBP treatment was among the best conditions for the degumming and individualisation of the fibers. The two-step boiled samples were tested. The results indicated that the length of mulberry fiber is 23.0-35.0mm, <br />fineness is 2.3-3.5 dT, breaking tenacity is 5.0-10.0cN/dT, breaking extension rate is 3.5-5.5%, moisture regain is <br />9-10%. The samples were observed by scanning electron microscopy (SEM), and the morphological aspects of the <br />mulberry fibers are discussed.Structural disruption was observed by X-ray measurement. 

Citation

FULL TEXT

 

Title

Cytotoxicity and L-amino acid oxidase activity of crude insect drugs.

Authors

Ahn MY, Ryu KS, Lee YW, Kim YS.

Department of Sericulture and Entomology, National Institute of Agricultural Science and Technology, Suwon, Korea. AMY@niast.go.kr

Journal

Arch Pharm Res. 2000 Oct;23(5):477-81.

Abstract

The cytotoxicity of crude insect drugs was measured using HeLa cells originating from human cervix and uterine cancer, using the dye uptake assay in order to find potential anticancer agents. Three kinds of extracts (buffer, methanol and ethylacetate) were prepared from 26 insects and used as raw materials for the activity assay. Among these, the buffer extracts from Tabanus, Mylabris and Huechys showed a potent anticancer activity, and those from Catharsius, Red ant, Scorpion, Tabanus and Vespae Nidus showed a strong L-amino acid oxidase (AAO) activity as well as cytotoxicity. In contrast, buffer extracts from Gryllotalpa orientalis and Apriona germari larvae showed greater/more rapid Hela cell growth than that of other insects.

Citation

http://www.ncbi.nlm.nih.gov/pubmed/11059827 PMID: 11059827 [PubMed - indexed for MEDLINE]

 

posted Jul 9, 2010, 9:12 AM by rajesh gk

Title

Effects of Cina on root-knot disease of mulberry.

Authors

Datta SC.

 

Department of Zoology, Visva-Bharati University, Santiniketan 731235, West Bengal, India. dattasubhas@rediffmail.com

Journal

Homeopathy. 2006 Apr;95(2):98-102.

Abstract

Root-knot disease of mulberry is caused by the nematode Meloidogyne incognita. It has important economic implications for sericulture. The homeopathic medicines, Cina mother tincture (MT) and potentised Cina 200C, prepared from the flowering meristems of Artemisia nilagirica (Clarke) Pamp, were applied by foliar spray on mulberry (Morus alba L.) infected with M. incognita juveniles (J2). Pretreatment (ending 6 days before inoculation) and post-treatment (starting 6 days after inoculation) schedules were tested. The two uninoculated control batches were treated with the same procedure with Cina MT and Cina 200C. Both pre- and post-treatment significantly reduced nematode infection in terms of root gall number and nematode population in root. All the treated plants showed improved growth in terms of fresh biomass of shoot and root, length of shoot and root, number of leaves, leaf surface area, root and leaf-protein content. Cina 200C is more effective than Cina MT in all respects of nematode control as well as growth of the test plants. Pretreatments show slightly better effects than the post-treatments. It is interesting that inoculated and treated plants not only are less affected by nematodes but also have a better growth than uninoculated, untreated control.

Citation

http://www.ncbi.nlm.nih.gov/pubmed/16569626 PMID: 16569626 [PubMed - indexed for MEDLINE]

posted Jul 5, 2010, 2:01 AM by rajesh gk

Title

Three new compounds from Morus nigra L.

Authors

Wang L, Yang Y, Liu C, Chen RY.

 

The Key Laboratory of Bioactive Substances and Resources Utilization of Chinese Herbal Medicine, Ministry of Education & Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.

Journal

J Asian Nat Prod Res. 2010 Jun;12(6):431-7.

Abstract

A new 2-arylbenzofuran derivative, mornigrol D (1), along with two new flavones, mornigrol G (2) and mornigrol H (3), and six known compounds, norartocarpetin (4), dihydrokaempferol (5), albanin A (6), albanin E (7), moracin M (8), and albafuran C (9), were isolated from the barks of Morus nigra. Their structures were elucidated by spectroscopic analysis. Compounds 1 and 9 showed antioxidative activities in vitro with inhibition ratios of 98 and 99% at the concentration of 10(-4) mol/l, and of 74 and 75% at the concentration of 10(-5) mol/l. In addition, compounds 1 and 4 showed potent anti-inflammatory activities (inhibition of release of beta-glucuronidase from rat polymorphonuclear leucocytes induced by platelet activating factor) with inhibitory ratios of 65.9% (P < 0.01) and 67.7% (P < 0.01) at a concentration of 10(-5) mol/l.

Citation

PMID: 20552479 [PubMed - in process]

 

Title

Chemical constituents of the stem bark of Morus cathayana.

Authors

Ni G, Zhang QJ, Wang YH, Chen RY, Zheng ZF, Yu DQ.

 

The Key Laboratory of Bioactive Substances and Resources Utilization of Chinese Herbal Medicine, Peking Union Medical College, Ministry of Education, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.

Journal

J Asian Nat Prod Res. 2010 Jun;12(6):505-15.

Abstract

Phytochemical investigation of the stem bark of Morus cathayana led to the isolation and identification of six new compounds, cathayanons F-J (1-5) and cathayanin A (6), and two known compounds, cathayanins B-C (7-8). Their structures were elucidated by spectroscopic methods. Compounds 1, 2, 3, 5, and 7 exhibited weak activities against five human cancer cell lines, with IC(50) values ranging from 4.7 to 9.8 microg/ml.

Citation

PMID: 20552491 [PubMed - in process]

 

 

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