Captain of this ship.
Reuben gew up in rural upstate New York, went
to Cornell for undergraduate school where he did his thesis work with Rick Cerione. He then went to MIT for graduate school and did his PhD work in Tyler Jacks' lab at the
MIT Cancer Center where he focused on neurofibromatosis. Reuben did his postdoctoral work
across the river at Harvard Medical School with Lew Cantley. The rest is in the
After completing his undergraduate degree in Biology at Colby
College in Waterville, Maine, Dan worked at Cell Signaling Technology
making and testing phospho-specific antibodies. Since joining the Shaw
Lab as a graduate student in the Biological
Sciences program, he has been working on identifying and characterizing
new substrates of the energy sensor AMPK.
The Mouse Whisperer
Jonathan is a graduate student in the Cellular and Molecular Genetics
Program at the University of California-San Diego (UCSD). He received
his bachelor’s degree in Biology from the University of
Massachusetts-Amherst in 2005. After his undergraduate career, he
worked for two years as a technician in the laboratory of Dr. Michael
Lanuti at Massachusetts General Hospital in Boston where he studied
oncolytic herpes viruses. Jonathan joined the lab in the Spring of 2008
and is currently working on identifying new substrates of the
MARK/Par-1 homologs, which are activated by the upstream tumor
suppressor LKB1. His work aims to provide further understanding of how
these conserved kinases regulate cellular polarity, cell division, and
canonical/non-canonical Wnt signaling.
The Mouse Whisperer's Assistant
Maria obtained her bachelor's degree in Molecular Genetics at Ohio
State University in 2005. As an undergraduate, she did research on the
neurofibromatosis type 2 (NF2) tumor suppressor gene in the laboratory
of Dr Long-Sheng Chang at Children's Hospital Research Institute in
Columbus. She entered the UCSD Biology Graduate Program in the fall of
2006 and joined the Shaw lab in 2007. Since joining the lab, her focus
has been on identifying novel AMPK substrates and understanding their
role in liver metabolism.
Rebecca graduated from The Ohio State University in 2004 with a B.S. in
molecular genetics. She entered Stony Brook University's graduate
program in genetics in 2004 and spent three years at Cold Spring Harbor
Laboratory working on cross-genomic screening and validation of novel
alterations in liver cancer. She joined the Shaw lab in 2007. Her
project in the lab involves studying the consequences of liver-specific
LKB1 loss, focusing on the function of LKB1 as a tumor suppressor in
mouse models of liver cancer.
Nate Young grew up in Rochester, New York.
From there he moved on to Vanderbilt University in Nashville, TN. He graduated
from Vanderbilt with a B.S. in Molecular and Cellular Biology. Nate's
desire to pursue a career in science led him to MIT, where he completed his
graduate work and received his Ph.D. in Biology. After spending years on
the other side of the U.S., Nate and his family decided to move to San Diego,
where he is now a Postdoctoral Fellow in the Shaw lab. His favorite part about
San Diego is the sunshine!
Bibiana is originally from
Porto, a very nice city located in the northern part of Portugal. She completed
her B.S. degree in Biology at the University of Aveiro in 2005, then
crossed the border to Madrid where she obtained her Ph.D. in 2009 in Molecular
Cytogenetics at the Spanish National Cancer Centre. She joined the Shaw lab in July 2010 and is mainly interested in
how LKB1 and AMPK can regulate cell polarity and asymmetrical cell division.
Matthew grew up in Mountain View, CA (home of Google!). He studied biochemistry as an undergraduate at Harvard and then returned to the Bay Area for his graduate work. He obtained his Ph.D. from UCSF, where he worked in the lab of Doug Hanahan to identify the genetic and molecular mechanisms that promote tumor invasion in pancreatic cancer. He joined the Shaw lab in the fall of 2010 and is currently interested in understanding and characterizing the role of the Lkb1 tumor suppressor in the development of lung cancer.
Erin Quan Toyama
Erin graduated from UC San Diego with a B.S. in Molecular Biology in 2003. She then moved to San Francisco, where she studied protein quality control in Saccharomyces cerevisae in Jonathan Weissman’s lab at UCSF. In 2009, Erin earned her Ph.D. in Biochemistry and Molecular Biology and decided to explore a new scientific direction. She subsequently joined the Shaw lab as a postdoctoral fellow and is interested in finding novel substrates of AMPK and dissecting their biochemical and biological function.
Originally from England, Rob's interest in research led him across the pond to pursue his PhD in Molecular Physiology and Biophysics at the University of Iowa. His PhD studies in the lab of Michael Henry focused on mouse models of prostate cancer progression and therapy. After developing an interest in cancer metabolism, Rob joined the Shaw lab as a post-doc in the summer of 2011. His projects involve understanding the tumor suppressor functions of LKB1 in mouse models of lung cancer and whether environmental factors such as diet and exercise that modulate LKB1 signaling might also contribute to tumorigenesis.
| |Daniel Garcia
Daniel grew up in a small town in central Mexico. He got his B.S. degree from UC San Diego and then completed his Ph.D. at UC San Francisco in Gerard Evan's lab, where he worked on p53 restoration in tumors and also on establishing a novel mouse model for E2F regulation. He joined the Shaw lab as a postdoc in 2011. He studies the effects of LKB1-AMPK pathway reactivation in tumors.